Masato Hasegawa 研究室

主宰者：Masato Hasegawa

Tokyo Metropolitan Institute of Medical Science

AI 要約（直近 5 年の研究成果）

本研究室は、神経変性疾患に見られるタンパク質の異常な蓄積と、その結果として生じる脳の障害メカニズムを明らかにすることを主な研究課題としています。特に、アルツハイマー病、パーキンソン病、筋萎縮性側索硬化症、前頭側頭葉変性症といった複数の疾患における、タウおよびシヌクレイン、TDP-43といった神経変性関連タンパク質の異常な凝集・蓄積が認知機能低下や運動障害などの臨床症状とどのように関連するのかを調べています。研究手法としては、剖検時に採取した患者脳組織の詳細な病理学的観察と、最新の電子顕微鏡技術（クライオ電子顕微鏡）を用いたタンパク質フィラメント構造解析を組み合わせたアプローチを採用しています。さらに動物モデルやセル培養系を用いた実験的検証や、既承認医薬品ライブラリーからのスクリーニングによる治療候補物質の探索も並行して実施しています。これらの多角的な研究から、各疾患特有のタンパク質凝集構造が臨床症状の多様性を規定していること、また異なる環境・遺伝要因によって同一の異常タンパク質構造が形成される場合があることなどが明らかになりつつあります。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（74 件）

[2025] Clinical neuropathology of early‐stage Pick's disease initially diagnosed as depressive disorder: A case report and case series comparison
DOI: https://doi.org/10.1002/pcn5.70116
[2025] Argyrophilic Grain Disease Clinically Presenting as Progressive Supranuclear Palsy with Progressive Gait Freezing
DOI: https://doi.org/10.1002/mdc3.70053
[2025] Neuropathological and Biochemical Profiles of Lewy Pathology in the Central and Peripheral Nervous Systems of an Autopsy Case of <scp>SNCA</scp> Duplication
DOI: https://doi.org/10.1111/neup.70020
[2025] Enhanced secretion of the amyotrophic lateral sclerosis ALS-associated misfolded TDP-43 mediated by the ER-ubiquitin specific peptidase USP19
DOI: https://doi.org/10.1007/s00018-025-05589-w
[2025] Biallelic variants in DNAJC7 cause familial amyotrophic lateral sclerosis with the TDP-43 pathology
DOI: https://doi.org/10.1007/s00401-025-02899-y
[2025] Motor involvement in frontotemporal lobar degeneration with <scp>TAR DNA</scp>‐binding protein of <scp>43 kDa</scp> type C
DOI: https://doi.org/10.1111/neup.13026
[2025] Argyrophilic grain disease: epidemiology and association with cognitive decline and parkinsonism
DOI: https://doi.org/10.1093/braincomms/fcaf352
[2024] Dynamic aphasia as an early sign of corticobasal degeneration: Clinico-radio-pathological correlation
DOI: https://doi.org/10.1016/j.ensci.2024.100526
[2024] Long-standing preservation of levodopa response in progressive supranuclear palsy
DOI: https://doi.org/10.1016/j.jns.2024.123203
[2024] Pure argyrophilic grain disease revisited: independent effects on limbic, neocortical, and striato-pallido-nigral degeneration and the development of dementia in a series with a low to moderate Braak stage
DOI: https://doi.org/10.1186/s40478-024-01828-6

続きを表示（残り 64 件）

[2024] Conventional magnetic resonance imaging key features for distinguishing pathologically confirmed corticobasal degeneration from its mimics: a retrospective analysis of the J-VAC study
DOI: https://doi.org/10.1007/s00234-024-03432-w
[2024] Neurofibrillary tangle-predominant dementia followed by amyloid β pathology: a clinico-radio-pathological case providing insights into current disease-modifying therapeutic strategy
DOI: https://doi.org/10.1186/s40478-024-01815-x
[2024] Imaging α-synuclein pathologies in animal models and patients with Parkinson’s and related diseases
DOI: https://doi.org/10.1016/j.neuron.2024.05.006
[2024] Effects of local reduction of endogenous α-synuclein using antisense oligonucleotides on the fibril-induced propagation of pathology through the neural network in wild-type mice
DOI: https://doi.org/10.1186/s40478-024-01766-3
[2024] An autopsy case of type A <scp>FTLD‐TDP</scp> with a <scp>GRN</scp> mutation presenting with the logopenic variant of primary progressive aphasia at onset and with corticobasal syndrome subsequently
DOI: https://doi.org/10.1111/neup.12980
[2024] Selection of lansoprazole from an FDA-approved drug library to inhibit the Alzheimer’s disease seed-dependent formation of tau aggregates
DOI: https://doi.org/10.3389/fnagi.2024.1368291
[2024] Clinicopathological study of dementia with grains presenting with parkinsonism compared with a typical case
DOI: https://doi.org/10.1111/neup.12973
[2024] Corticobasal degeneration with visual hallucination as an initial symptom: A case report
DOI: https://doi.org/10.1111/neup.12963
[2024] Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G
DOI: https://doi.org/10.1007/s00401-024-02741-x
[2024] Cerebral hypoperfusion reduces tau accumulation
DOI: https://doi.org/10.1002/acn3.52247
[2024] A novel peptide‐based tau aggregation inhibitor as a potential therapeutic for Alzheimer's disease and other tauopathies
DOI: https://doi.org/10.1002/alz.14246
[2024] Analysis and comparison of post-translational modifications of α-synuclein filaments in multiple system atrophy and dementia with Lewy bodies
DOI: https://doi.org/10.1038/s41598-024-74130-z
[2024] Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C
DOI: https://doi.org/10.1038/s41586-024-08024-5
[2023] Ultrastructures of α-Synuclein Filaments in Synucleinopathy Brains and Experimental Models
DOI: https://doi.org/10.14802/jmd.23213
[2023] Phosphorylation of α-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson’s disease
DOI: https://doi.org/10.1073/pnas.2214652120
[2023] Tunnelling nanotubes between neuronal and microglial cells allow bi-directional transfer of α-Synuclein and mitochondria
DOI: https://doi.org/10.1038/s41419-023-05835-8
[2023] Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy
DOI: https://doi.org/10.1186/s40478-023-01565-2
[2023] Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold
DOI: https://doi.org/10.1073/pnas.2306767120
[2023] The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not amyotrophic lateral sclerosis
DOI: https://doi.org/10.1093/brain/awad410
[2023] Dysregulation of the progranulin-driven autophagy-lysosomal pathway mediates secretion of the nuclear protein TDP-43
DOI: https://doi.org/10.1016/j.jbc.2023.105272
[2023] Atypical TDP‐43 proteinopathy clinically presenting with progressive nonfluent aphasia: A case report
DOI: https://doi.org/10.1111/neup.12942
[2023] A heterozygous splicing variant IVS9-7A > T in intron 9 of the MAPT gene in a patient with right-temporal variant frontotemporal dementia with atypical 4 repeat tauopathy
DOI: https://doi.org/10.1186/s40478-023-01629-3
[2023] Distinct tau folds initiate templated seeding and alter the post-translational modification profile
DOI: https://doi.org/10.1093/brain/awad272
[2023] TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP
DOI: https://doi.org/10.1038/s41586-023-06405-w
[2023] <scp>Cryo‐EM</scp> structures of tau filaments from <scp>SH‐SY5Y</scp> cells seeded with brain extracts from cases of Alzheimer's disease and corticobasal degeneration
DOI: https://doi.org/10.1002/2211-5463.13657
[2023] Neuropathology of spinocerebellar ataxia type 8: Common features and unique tauopathy
DOI: https://doi.org/10.1111/neup.12894
[2023] An autopsy case of progressive supranuclear palsy treated with monoclonal antibody against tau
DOI: https://doi.org/10.1111/neup.12890
[2023] Clinical course of pathologically confirmed corticobasal degeneration and corticobasal syndrome
DOI: https://doi.org/10.1093/braincomms/fcad296
[2023] Spreading of 3-repeat tau pathology in tau knock-in mice
DOI: https://doi.org/10.1254/jpssuppl.97.0_2-b-p-031
[2022] Phosphorylation of endogenous α-synuclein induced by extracellular seeds initiates at the pre-synaptic region and spreads to the cell body
DOI: https://doi.org/10.1038/s41598-022-04780-4
[2022] LATE-NC staging in routine neuropathologic diagnosis: an update
DOI: https://doi.org/10.1007/s00401-022-02524-2
[2022] Synthesis and Evaluation of 18F-Labeled Chalcone Analogue for Detection of α-Synuclein Aggregates in the Brain Using the Mouse Model
DOI: https://doi.org/10.1021/acschemneuro.2c00473
[2022] Structures of α-synuclein filaments from human brains with Lewy pathology
DOI: https://doi.org/10.1038/s41586-022-05319-3
[2022] Kinematic Differences Between the Dominant and Nondominant Legs During a Single-Leg Drop Vertical Jump in Female Soccer Players
DOI: https://doi.org/10.1177/03635465221107388
[2022] An autopsy case of progressive supranuclear palsy. Pallido‐nigro‐luysian type with argyrophilic grains clinically presenting with personality and behavioral changes
DOI: https://doi.org/10.1111/neup.12815
[2022] Casein kinase 1δ/ε phosphorylates fused in sarcoma (FUS) and ameliorates FUS-mediated neurodegeneration
DOI: https://doi.org/10.1016/j.jbc.2022.102191
[2022] Frontotemporal Lobar Degeneration With Unclassifiable 4-Repeat Tauopathy Mimicking Globular Glial Tauopathy
DOI: https://doi.org/10.1093/jnen/nlac039
[2022] An autopsy case of <scp>MV2K</scp>‐type sporadic <scp>Creutzfeldt‐Jakob</scp> disease presenting with characteristic clinical, radiological, and neuropathological findings
DOI: https://doi.org/10.1111/neup.12804
[2022] Independent distribution between tauopathy secondary to subacute sclerotic panencephalitis and measles virus: An immunohistochemical analysis in autopsy cases including cases treated with aggressive antiviral therapies
DOI: https://doi.org/10.1111/bpa.13069
[2022] Age-dependent formation of TMEM106B amyloid filaments in human brains
DOI: https://doi.org/10.1038/s41586-022-04650-z
[2022] Pathologically Verified Corticobasal Degeneration Mimicking Richardson's Syndrome Coexisting with Clinically and Radiologically Shunt‐Responsive Normal Pressure Hydrocephalus
DOI: https://doi.org/10.1002/mdc3.13442
[2022] Synthesis and evaluation of novel radioiodinated phenylbenzofuranone derivatives as α-synuclein imaging probes
DOI: https://doi.org/10.1016/j.bmcl.2022.128679
[2022] Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration
DOI: https://doi.org/10.1093/brain/awac091
[2022] Neuropathological investigation of patients with prolonged anorexia nervosa
DOI: https://doi.org/10.1111/pcn.13340
[2022] A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics
DOI: https://doi.org/10.1186/s40478-022-01314-x
[2022] An autopsy case of <scp>A</scp>lzheimer's disease with amygdala‐predominant <scp>L</scp>ewy pathology presenting with frontotemporal dementia‐like psychiatric symptoms
DOI: https://doi.org/10.1111/neup.12786
[2021] Seeded assembly in vitro does not replicate the structures of α‐synuclein filaments from multiple system atrophy
DOI: https://doi.org/10.1002/2211-5463.13110
[2021] Human tauopathy-derived tau strains determine the substrates recruited for templated amplification
DOI: https://doi.org/10.1093/brain/awab091
[2021] An autopsy case of corticobasal syndrome due to asymmetric degeneration of the motor cortex and substantia nigra with <scp>TDP</scp>‐43 proteinopathy, associated with <scp>Alzheimer's</scp> disease pathology
DOI: https://doi.org/10.1111/neup.12723
[2021] Chalcone Analogue as New Candidate for Selective Detection of α-Synuclein Pathology
DOI: https://doi.org/10.1021/acschemneuro.1c00441
[2021] Structure of pathological TDP-43 filaments from ALS with FTLD
DOI: https://doi.org/10.1038/s41586-021-04199-3
[2021] An immigrant family with Kii amyotrophic lateral sclerosis/parkinsonism–dementia complex
DOI: https://doi.org/10.1007/s10072-021-05737-7
[2021] Structure-based classification of tauopathies
DOI: https://doi.org/10.1038/s41586-021-03911-7
[2021] Development of a novel tau propagation mouse model endogenously expressing 3 and 4 repeat tau isoforms
DOI: https://doi.org/10.1093/brain/awab289
[2021] Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of β-secretase BACE1
DOI: https://doi.org/10.1093/jb/mvab094
[2021] Distinct phosphorylation profiles of tau in brains of patients with different tauopathies
DOI: https://doi.org/10.1016/j.neurobiolaging.2021.08.011
[2021] Tau Protein and Frontotemporal Dementias
DOI: https://doi.org/10.1007/978-3-030-51140-1_12
[2021] Macaca fuscataにおけるリン酸化α-シヌクレインの進行【JST・京大機械翻訳】
[2021] The hot cross bun sign in corticobasal degeneration
DOI: https://doi.org/10.1111/neup.12745
[2021] An autopsied FTDP-17 case with MAPT IVS 10 + 14C > T mutation presenting with frontotemporal dementia
DOI: https://doi.org/10.1016/j.ensci.2021.100363
[2021] α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes
DOI: https://doi.org/10.1371/journal.pbio.3001287
[2021] Essential roles of plexin-B3+ oligodendrocyte precursor cells in the pathogenesis of Alzheimer’s disease
DOI: https://doi.org/10.1038/s42003-021-02404-7
[2021] Amyotrophic lateral sclerosis with speech apraxia, predominant upper motor neuron signs, and prominent iron accumulation in the frontal operculum and precentral gyrus
DOI: https://doi.org/10.1111/neup.12763
[2021] An autopsy case of corticobasal degeneration with inferior olivary hypertrophy
DOI: https://doi.org/10.1111/neup.12725

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（74 件）

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