Kazuo Tomita 研究室

主宰者：Kazuo Tomita

鹿児島大学

AI 要約（直近 5 年の研究成果）

富田和男研究室は、細胞内の物質輸送や信号伝達に関わる分子機構と、それが生体現象に及ぼす影響を研究しています。特に、細胞死のメカニズム、神経機能の調節、および薬物の作用機序に焦点を当てています。一つの主要な研究テーマは、放射線に対する耐性を獲得したがん細胞の性質解明です。研究室では長期の生細胞観察を用いて、放射線照射後に細胞がアポトーシスだけでなく、自食作用や鉄代謝異常に関連した細胞死など多様なメカニズムで死滅することを報告しています。さらに、これらの耐性細胞の放射線感受性を回復させるための分子標的に関する研究も進めています。もう一つの重要な研究領域は、脳内のイオン輸送体であるKCC2の発現と機能に関するものです。細菌由来の毒素やストレス条件がKCC2を低下させることで、統合失調症などの神経疾患が引き起こされる可能性に着目し、これを改善する物質や伝統医学の効果を検証しています。また、覚醒剤や麻薬などの薬物が脳内の特定の酵素系を通じて行動異常を引き起こす機構についても、動物実験を用いた行動薬理学的研究で解明を進めています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（55 件）

[2025] 放射線抵抗性がん細胞の動態解明に向けた長期ライブセルイメージングの活用
[2025] Amoxicillin, a β-lactam antibiotic, enhances cisplatin sensitivity in cancer cells affecting mitochondria
DOI: https://doi.org/10.1016/j.bbrc.2025.151888
[2025] The radioresistance of clinically relevant radioresistant cell-derived tumors is determined by the cancer cells themselves, rather than by the surrounding stromal cells
DOI: https://doi.org/10.1016/j.jds.2025.06.024
[2025] Unlocking the potential of mitochondrial transplantation: overcoming challenges and paving the way for routine therapeutic application
DOI: https://doi.org/10.1007/s10616-025-00805-8
[2025] Pretreatment with LY2090314, a potent glycogen synthase kinase-3 inhibitor, suppresses methamphetamine-induced stereotyped behavior but not hyperlocomotion in mice
DOI: https://doi.org/10.1097/fbp.0000000000000853
[2024] Protein phosphatase 2A inhibitors: a possible pharmacotherapy for benzodiazepine dependence
DOI: https://doi.org/10.1093/jpp/rgae136
[2024] Silver Nanoparticles Reduce ACE2 Expression via Changing Mitochondrial Function in Human Fibroblast-Like Lung Cell and Periodontal Ligament Fibroblast Cells
DOI: https://doi.org/10.1007/s12668-024-01630-7
[2024] Opioid receptor antagonists reduce motivated wheel-running behavior in mice
DOI: https://doi.org/10.1097/fbp.0000000000000769
[2023] Pretreatment with CHIR-99021, a GSK-3 inhibitor, attenuates morphine-induced Straub tail reaction and withdrawal.
DOI: https://doi.org/10.1254/jpssuppl.97.0_3-b-p-105
[2023] Kamishoyosan and Kamikihito protect against decreased KCC2 expression induced by the P. gingivalis lipopolysaccharide treatment in PC-12 cells and improve behavioral abnormalities in male mice
DOI: https://doi.org/10.1016/j.heliyon.2023.e22784

続きを表示（残り 45 件）

[2023] Therapeutic potential for KCC2-targeted neurological diseases
DOI: https://doi.org/10.1016/j.jdsr.2023.11.001
[2023] Human umbilical cord-derived mesenchymal stem cells-harvested mitochondrial transplantation improved motor function in TBI models through rescuing neuronal cells from apoptosis and alleviating astrogliosis and microglia activation
DOI: https://doi.org/10.1016/j.intimp.2023.110106
[2023] Mitochondrial transfer in PC-3 cells fingerprinted in ferroptosis sensitivity: a brand new approach targeting cancer metabolism
DOI: https://doi.org/10.1007/s13577-023-00896-5
[2023] Glycogen Synthase Kinase-3 Inhibitors Block Morphine-Induced Locomotor Activation, Straub Tail, and Depression of Rearing in Mice Via a Possible Central Action
DOI: https://doi.org/10.1007/s11064-023-03902-2
[2023] Development of a sensitive double TaqMan Probe-based qPCR Angle-Degree method to detect mutation frequencies
DOI: https://doi.org/10.1016/j.mito.2023.02.010
[2023] The reversibility of cancer radioresistance: a novel potential way to identify factors contributing to tumor radioresistance
DOI: https://doi.org/10.1007/s13577-023-00871-0
[2023] The effect of diazepam on aggressive biting behavior of isolation-reared ddY mouse is different between male and female.
DOI: https://doi.org/10.1254/jpssuppl.97.0_1-b-yia3-3
[2023] Effects of pretreatment with LY2090314, a potent glycogen synthase kinase-3 inhibitor, on methamphetamine-induced hyperlocomotion and stereotypy in mice
DOI: https://doi.org/10.1254/jpssuppl.97.0_3-b-p-075
[2023] A psychedelic substance 2,5-dimethoxy-4-iodoamphetamine induces impairments in spatial short-term memory and retrieval and mood in mice
DOI: https://doi.org/10.1254/jpssuppl.97.0_3-b-p-070
[2023] Expression analysis of equilibrative nucleoside transporter 3 (ENT3) in cultured astrocytes
DOI: https://doi.org/10.1254/jpssuppl.97.0_2-b-p-016
[2023] Characteristics of behavioral abnormalities induced by a psychedelic substance 2,5-dimethoxy-4-iodoamphetamine in mice
DOI: https://doi.org/10.1254/jpssuppl.97.0_3-b-p-076
[2023] Effects of a single administration with opioid receptor antagonist naloxone on motivative behavior and brain monoamine turnover in mice
DOI: https://doi.org/10.1254/jpssuppl.97.0_3-b-p-071
[2023] Wortmannin, a potent phosphatidylinositol 3-kinase inhibitor, suppresses methamphetamine-induced stereotyped sniffing and biting, ameliorating the frequency of total stereotypy in mice
DOI: https://doi.org/10.1254/jpssuppl.97.0_3-b-p-077
[2023] Decreased Fe2+ amount returns to the parental levels when clinically relevant radioresistant cells lose their radio-resistance
DOI: https://doi.org/10.1254/jpssuppl.97.0_2-b-p-048
[2022] Expression of equilibrative nucleoside transporters and activity regulation by hydrogen peroxide in cultured astrocytes
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-p-019
[2022] Tumor radioresistance caused by radiation-induced changes of stem-like cell content and sub-lethal damage repair capability
DOI: https://doi.org/10.1038/s41598-022-05172-4
[2022] What symptoms are associated with aggressive biting behavior of isolation-reared mice?
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-p-036
[2022] Effects of pretreatment with a glycogen synthase kinase-3 inhibitor on methamphetamine-induced hyperlocomotion, stereotypy and reward in mice
DOI: https://doi.org/10.1254/jpssuppl.95.0_3-p-211
[2022] miR-7-5p inhibition induces ferroptosis by increasing ROS and Fe2+ in clinically relevant radioresistant cells
DOI: https://doi.org/10.1254/jpssuppl.95.0_3-p-282
[2022] Glycogen synthase kinase-3 inhibitors suppress morphine-induced Straub‘s tail reaction via a centrally acting mechanism
DOI: https://doi.org/10.1254/jpssuppl.95.0_3-p-212
[2022] Expression and function of equilibrative nucleoside transporters in cultured astrocytes
DOI: https://doi.org/10.1254/jpssuppl.96.0_4-b-p-287
[2022] RAGE, which is the receptor for advanced glycation end-products, is involved in the regulation of KCC2 expression by the Porphyromonas gingivalis LPS treatment in PC-12 cells.
DOI: https://doi.org/10.1254/jpssuppl.96.0_2-b-p-175
[2022] Effect of μ-opioid receptor selective antagonist β-funaltrexamine on spontaneous behavior in mice
DOI: https://doi.org/10.1254/jpssuppl.96.0_1-b-p-034
[2022] Neuroprotective effect of oxytocin on cognitive dysfunction, DNA damage, and intracellular chloride disturbance in young mice after cranial irradiation
DOI: https://doi.org/10.1016/j.bbrc.2022.04.099
[2022] CRISPR/Cas9-mediated knockout of Lcn2 in human breast cancer cell line MDA-MB-231 ameliorates erastin-mediated ferroptosis and increases cisplatin vulnerability
DOI: https://doi.org/10.1016/j.lfs.2022.120704
[2022] Pretreatment with CHIR-99021, a GSK-3 inhibitor, partially attenuates methamphetamine-induced stereotyped behavior in mice
DOI: https://doi.org/10.1254/jpssuppl.96.0_1-b-p-035
[2022] Oxytocin administration to head gamma-irradiated mice results in increased KCC2 mRNA expression through decreased phosphorylated CREB
DOI: https://doi.org/10.1254/jpssuppl.96.0_4-b-p-306
[2022] Natural killer cell immunotherapy in glioblastoma
DOI: https://doi.org/10.1007/s12672-022-00567-1
[2022] Mitochondria: how eminent in ageing and neurodegenerative disorders?
DOI: https://doi.org/10.1007/s13577-022-00833-y
[2022] 4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression
DOI: https://doi.org/10.3390/cells11233780
[2022] Are Histamine H3 Antagonists the Definitive Treatment for Acute MethamphetamineIntoxication?
DOI: https://doi.org/10.2174/2589977514666220414122847
[2022] Non-coding RNAs in ferroptotic cancer cell death pathway: meet the new masters
DOI: https://doi.org/10.1007/s13577-022-00699-0
[2021] Kamishoyosan reduces aggressive behavior of isolated-reared mice toward inanimate objects and involvement of estrogen receptor β
DOI: https://doi.org/10.1254/jpssuppl.94.0_2-p1-37
[2021] Study of immunocytochemistry in expression of nucleoside transporter ENT3 in astrocytes
DOI: https://doi.org/10.1254/jpssuppl.94.0_1-p1-19
[2021] LPS decrease KCC2 expression in primary rat cerebral cortex cells and PC-12 cells
DOI: https://doi.org/10.1254/jpssuppl.94.0_2-p1-18
[2021] Mitochondrial Dysfunction in Diseases, Longevity, and Treatment Resistance: Tuning Mitochondria Function as a Therapeutic Strategy
DOI: https://doi.org/10.3390/genes12091348
[2021] Metoprine, a histamine N-methyltransferase inhibitor, attenuates methamphetamine-induced hyperlocomotion via activation of histaminergic neurotransmission in mice
DOI: https://doi.org/10.1016/j.pbb.2021.173257
[2021] MiR-7-5p Is Involved in Ferroptosis Signaling and Radioresistance Thru the Generation of ROS in Radioresistant HeLa and SAS Cell Lines
DOI: https://doi.org/10.3390/ijms22158300
[2021] Diurnal Variation in Trigeminal Pain Sensitivity in Mice
DOI: https://doi.org/10.3389/fnins.2021.703440
[2021] Inhibitory effect of SB216763, a selective glycogen synthase kinase-3 inhibitor, on morphine-induced Straub’s tail reaction in mice
DOI: https://doi.org/10.1254/jpssuppl.94.0_3-p1-11
[2021] Kamishoyosan (a Japanese traditional herbal formula), which effectively reduces the aggressive biting behavior of male and female mice, and potential regulation through increase of Tph1, Tph2, and Esr2 mRNA levels
DOI: https://doi.org/10.1016/j.brainres.2021.147580
[2021] Oxytocin ameliorates KCC2 decrease induced by oral bacteria-derived LPS that affect rat primary cultured cells and PC-12 cells
DOI: https://doi.org/10.1016/j.peptides.2021.170734
[2021] Pharmacological Targeting of Ferroptosis in Cancer Treatment
DOI: https://doi.org/10.2174/1568009621666211202091523
[2021] Decreased mitochondrial membrane potential is an indicator of radioresistant cancer cells
DOI: https://doi.org/10.1016/j.lfs.2021.120051
[2021] Cashing in on ferroptosis against tumor cells: Usher in the next chapter
DOI: https://doi.org/10.1016/j.lfs.2021.119958

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AI 要約（直近 5 年の研究成果）

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研究成果（55 件）

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