Toshihiro Ishii 研究室

主宰者：Toshihiro Ishii

東邦大学

AI 要約（直近 5 年の研究成果）

本研究室は、医薬品の安全性に関する大規模データベースを活用した薬剤疫学研究を主に実施しています。日本の医薬品有害事象自発報告データベース（JADER）を用いて、様々な医薬品の副作用の特徴、発症パターン、発症時間、危険因子を多角的に分析する研究を行っています。具体的には、がん治療薬、免疫調整薬、抗ウイルス薬、ワクチンなど幅広い医薬品による副作用事例を統計解析することで、医療現場で見落とされやすい有害事象の新たな知見を引き出しています。また、臨床の現場観察も重視しており、個別の患者症例の詳細な検討と大規模データベース分析を組み合わせることで、複雑な医学的現象をより深く理解しようとしています。さらに、治療薬の血中濃度予測精度の検証など、薬物動態学的な研究も行っています。高齢患者や免疫不全患者など特定の患者集団における薬物治療の実態把握も関心事の一つです。これらの研究を通じて、医薬品の安全で効果的な使用を実現し、臨床医や患者にとって有用な情報提供を行うことが、本研究室の基本的な目標となっています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（28 件）

[2026] Seasonal Variation in Reporting of Venous Thromboembolism in a Spontaneous Adverse Event Reporting System: Analysis of the Japanese Adverse Drug Event Report Database
DOI: https://doi.org/10.2147/dhps.s615764
[2026] Cutaneous lymphomas reported following the use of dupilumab, nemolizumab, tralokinumab, or lebrikizumab: A case investigation based on JADER database and disproportionality analysis
DOI: https://doi.org/10.5582/irdr.2026.01017
[2025] Fact-Finding Survey of Lethal or Fatal Adverse Drug Events in the Japanese Adverse Drug Event Report Database, Fiscal Year 2004–2023 (Adults ≥ 20 Years)
DOI: https://doi.org/10.3390/pharma4040019
[2025] 2. Formation and Production of Powder and Particles　2.4 Grinding and Mechanochemistry　2.4.2 Fundamentals of Wet Grinding and Dispersion
DOI: https://doi.org/10.4164/sptj.62.512
[2025] Risk Factors for Vancomycin-Induced Nephrotoxicity and Kidney Prognosis in Patients Aged 75 Years and Older: A Retrospective Study
DOI: https://doi.org/10.1007/s40266-025-01203-7
[2025] Characteristics and patterns of adverse event reports in the Japanese Adverse Drug Event Report database over two decades (2004–2023): Exploring findings on sexes and age groups
DOI: https://doi.org/10.5582/ddt.2024.01090
[2024] Influence of rapidly increased numbers of reports on adverse events of the COVID-19 vaccine in the Japanese pharmacovigilance database on disproportionality analysis of antineoplastic drug-associated adverse cardiovascular events
DOI: https://doi.org/10.1080/14740338.2024.2448830
[2024] Retrospective Study of Factors Affecting the Accuracy of Predicting Vancomycin Concentrations in Patients Aged 75 Years and Above
DOI: https://doi.org/10.3390/medicina60081273
[2024] Fact-Finding Survey and Exploration of Preventive Drugs for Antineoplastic Drug-Induced Oral Mucositis Using the Japanese Adverse Drug Event Report Database
DOI: https://doi.org/10.3390/scipharm92020034
[2024] Adverse Event Profile of Atezolizumab, Bevacizumab, Carboplatin, and Paclitaxel Combination Therapy Based on JADER
DOI: https://doi.org/10.21873/anticanres.17072

続きを表示（残り 18 件）

[2023] Bibliometric analysis of Kampo medicine hotspots and trends for the decade: 2013–2022
DOI: https://doi.org/10.1097/md.0000000000035897
[2023] Mechanical Synthesis of Lithium Titanate Hydrate in Liquid Phase Using a High Centrifugal Bead Mill
DOI: https://doi.org/10.4164/sptj.60.536
[2023] An Unusual Case of Sarcoidosis with a Prolonged Fever and Progressive Arthropathy
DOI: https://doi.org/10.2169/internalmedicine.1890-23
[2023] Characteristics of adverse event reports among people living with human immunodeficiency virus (HIV) in Japan: Data mining of the Japanese Adverse Drug Event Report database
DOI: https://doi.org/10.5582/ddt.2023.01007
[2023] Analysis of COVID-19 mRNA Vaccine-induced Mouth Ulcers Using the Japanese Adverse Drug Event Report Database
DOI: https://doi.org/10.31083/ph.2023.3521
[2023] Bleeding events associated with recombinant human soluble thrombomodulin, classified according to renal function, in sepsis-induced disseminated intravascular coagulation
DOI: https://doi.org/10.5414/cp204362
[2023] Accuracy of Therapeutic Drug Monitoring of Teicoplanin at the Onset of Febrile Neutropenia
DOI: https://doi.org/10.3390/medicina59040758
[2023] Positive Rate and Utility of Blood Culture among Nursing and Healthcare-associated Pneumonia Inpatients: A Cross-sectional Study
DOI: https://doi.org/10.2169/internalmedicine.1008-22
[2022] Time to Onset of Gemcitabine-induced Thrombotic Microangiopathy in a Japanese Population: A Case Series and Large-scale Pharmacovigilance Analysis
DOI: https://doi.org/10.21873/cdp.10188
[2022] Chemical Stability after Mixing Continuous Infusion Drugs Used to Treat Cardiogenic Shock
DOI: https://doi.org/10.1248/yakushi.22-00138
[2022] Understanding the Actual Use of Anti-HIV Drugs in Japan from 2016 to 2019: Demonstrating Epidemiological Relevance of NDB Open Data Japan for Understanding Japanese Medical Care
DOI: https://doi.org/10.3390/ijerph191912130
[2022] Wet milling synthesis of ammonium cobalt phosphate hydrate platelets for LCP‐olivine cathodes of LIBs using a bead mill
DOI: https://doi.org/10.1111/ijac.14147
[2022] Mechanical Synthesis of Lithium Titanate Hydrate in Liquid Phase Using a Bead Mill
DOI: https://doi.org/10.4164/sptj.59.324
[2021] Plasma Exchange Did Not Reduce Viral Load in a Recovered Case of Severe Fever with Thrombocytopenia Syndrome
DOI: https://doi.org/10.2169/internalmedicine.7075-21
[2021] Association between anaphylaxis and anti-influenza drug use: An analysis of the Japanese Adverse Drug Event Report database
DOI: https://doi.org/10.5582/ddt.2021.01053
[2021] Evaluation of eustachian tube function using a portable device
DOI: https://doi.org/10.1121/10.0005406
[2021] Analysis of the Time-To-Onset and Factors Affecting Clinical Outcomes of Immune Reconstitution Inflammatory Syndrome in People Living with HIV Using Data from the Japanese Spontaneous Reporting Database
DOI: https://doi.org/10.18433/jpps31675
[2021] Comparative Study of Different Epidermal Growth Factor Receptor (EGFR)-Tyrosine Kinase Inhibitors Affecting Lung Cancer Cell Lines Stably Overexpressing EGFR Mutations
DOI: https://doi.org/10.1248/bpbreports.4.1_12

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（28 件）

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所属学会・役職（0 件）