Yu Shimizu 研究室

主宰者：Yu Shimizu

北海道大学

AI 要約（直近 5 年の研究成果）

本研究室は、心臓不整脈や脊椎疾患などの医学的課題に対して、臨床データと先進的な解析手法を組み合わせた研究を展開しています。特に心房細動に対するカテーテルアブレーション治療の効果予測、ペースメーカー植込み後の心機能低下の発症予測、脊椎手術の高齢患者への適用可能性などを調査の対象としています。これらの研究では、心電図やエコー検査といった臨床データをもとに、人工知能の一種である深層学習アルゴリズムを用いて疾患の進行や治療効果を事前に予測するモデルを開発しており、患者選別や治療方針の最適化に貢献することを目指しています。同時に、腸内細菌叢と宿主の健康状態の関連性についても研究を進めています。特に小腸の上皮細胞が分泌する抗菌ペプチドが腸内細菌の構成をどのように制御し、睡眠不足や食生活といった環境因子がこの仕組みに影響を与えるのか、さらには肝臓疾患などの全身疾患とどのように関連するのかを明らかにしようとしています。また、便中微生物移植療法の有効性や予測因子について、メタゲノムス解析や代謝産物の測定といった多角的なアプローチで検証する研究も行われています。これらの研究活動を通じて、本研究室は基礎的な生物学的メカニズムの理解と臨床応用の両面から、患者の予後改善と治療の個別化に貢献する知見の創出を目指しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（50 件）

[2026] Comparative study of posterior lumbar interbody fusion using expandable cages versus lateral lumbar interbody fusion for lumbar canal stenosis associated with osteoporotic vertebral fractures: a multicenter retrospective cohort study
DOI: https://doi.org/10.1016/j.wneu.2026.125079
[2026] WCN26-1569 Predictors of Peritoneal dialysis withdrawal: A retrospective study in a Single Japanese Center
DOI: https://doi.org/10.1016/j.ekir.2026.105843
[2026] Inspiratory muscle training after atrial fibrillation catheter ablation: A pilot study: Erratum
DOI: https://doi.org/10.1097/md.0000000000048174
[2026] Benchtop NMR-based lactose quantification in human milk: correction of oligosaccharide interference and comparison with high-field NMR
DOI: https://doi.org/10.1016/j.microc.2026.118371
[2026] Post-weaning gut microbiota colonization in germ-free mice results in crinophagy-like granule abnormalities and apoptosis in Paneth cells
DOI: https://doi.org/10.1016/j.bbrc.2026.153973
[2025] Long-Term Implantable Cardioverter Defibrillator Lead Dysfunction After Left Ventricular Assist Device Implantation
DOI: https://doi.org/10.1016/j.jacadv.2025.102258
[2025] Heart failure monitoring with a single‑lead electrocardiogram at home
DOI: https://doi.org/10.1016/j.ijcard.2025.133203
[2025] Results of Spine Surgeries in Nonagenarians Compared with Octogenarians: A Propensity-Matched Analysis
DOI: https://doi.org/10.1016/j.wneu.2025.124520
[2025] Total Atrial Conduction Time as a Predictor of Left Atrial Functional Recovery in Atrial Fibrillation
DOI: https://doi.org/10.1016/j.jacadv.2025.102151
[2025] PO-06-134 THE LONG-TERM INCIDENCE AND RISK FACTOR OF IMPLANTABLE CARDIOVERTER DEFIBRILLATOR LEAD DYSFUNCTION AFTER LEFT VENTRICULAR ASSIST DEVICE IMPLANTATION
DOI: https://doi.org/10.1016/j.hrthm.2025.03.1675

続きを表示（残り 40 件）

[2025] Modulation of Bifidobacterium by HD5 during weaning is associated with high abundance in later life
DOI: https://doi.org/10.1038/s43856-025-00977-6
[2025] Genotype-Guided Cardiac Device Intervention in <i>LMNA</i> -Related Cardiac Conduction Disorder: The Need for Timely Genetic Testing
DOI: https://doi.org/10.1002/ejhf.3695
[2024] Prediction of pacemaker-induced cardiomyopathy using a convolutional neural network based on clinical findings prior to pacemaker implantation
DOI: https://doi.org/10.1038/s41598-024-57418-y
[2024] The impact of hip mobility on spinopelvic sagittal alignment: A comparative study of THA patients and healthy volunteers
DOI: https://doi.org/10.1016/j.bas.2024.102963
[2024] Freeze-dried fecal microorganisms as an effective biomaterial for the treatment of calves suffering from diarrhea
DOI: https://doi.org/10.1038/s41598-024-79267-5
[2024] Evaluation of the Bone Union Occurring Subsequent to C1-2 Fusion Combined With C1 Laminectomy for the Surgical Treatment of Retro-Odontoid Pseudotumor
DOI: https://doi.org/10.7759/cureus.63422
[2024] Accuracy of Cervical Pedicle Screw Insertion With and Without a Navigation-Linked High-Speed Drill: A Retrospective Clinical Study
DOI: https://doi.org/10.7759/cureus.68558
[2024] Body Fat Distribution and Left Atrial Reverse Remodeling After Catheter Ablation for Atrial Fibrillation
DOI: https://doi.org/10.1016/j.jacadv.2024.100973
[2024] Iatrogenic vertebral artery injury during catheter ablation treated using coil embolization
DOI: https://doi.org/10.1111/pace.14970
[2024] A leadless pacemaker implantation for a patient with systemic right ventricle under ventricular assist device support
DOI: https://doi.org/10.1016/j.jccase.2024.02.004
[2023] CT-based analysis of sagittal and coronal lumbar endplate morphology: multivariate analysis of factors associated with endplate depth
DOI: https://doi.org/10.1007/s00586-023-07642-3
[2023] The relationship between spino-pelvic-hip mobility and quality of life before and after total hip arthroplasty
DOI: https://doi.org/10.1007/s00402-023-05094-4
[2023] Cryoballoon ablation for paroxysmal atrial fibrillation mildly improves lung function: An observational study
DOI: https://doi.org/10.1097/md.0000000000035991
[2023] The estimated glomerular filtration rate predicts pacemaker-induced cardiomyopathy
DOI: https://doi.org/10.1038/s41598-023-43953-7
[2023] A Basic Study of the Effects of Mulberry Leaf Administration to Healthy C57BL/6 Mice on Gut Microbiota and Metabolites
DOI: https://doi.org/10.3390/metabo13091003
[2023] Shorter sleep time relates to lower human defensin 5 secretion and compositional disturbance of the intestinal microbiota accompanied by decreased short-chain fatty acid production
DOI: https://doi.org/10.1080/19490976.2023.2190306
[2023] Decreased Paneth cell α-defensins promote fibrosis in a choline-deficient L-amino acid-defined high-fat diet-induced mouse model of nonalcoholic steatohepatitis via disrupting intestinal microbiota
DOI: https://doi.org/10.1038/s41598-023-30997-y
[2023] Synergistic effect of sulfonation followed by precipitation of amorphous calcium phosphate on the bone-bonding strength of carbon fiber reinforced polyetheretherketone
DOI: https://doi.org/10.1038/s41598-023-28701-1
[2022] The Impact of Hip Mobility on Lumbar and Pelvic Mobility before and after Total Hip Arthroplasty
DOI: https://doi.org/10.3390/jcm12010331
[2022] Reactive granulopoiesis depends on T-cell production of IL-17A and neutropenia-associated alteration of gut microbiota
DOI: https://doi.org/10.1073/pnas.2211230119
[2022] Prediction of Atrial Fibrillation Being Asymptomatic at First Onset by Cardiac Pacing
DOI: https://doi.org/10.1536/ihj.21-594
[2022] Bioactivity and antibacterial activity of iodine-containing calcium titanate against implant-associated infection
DOI: https://doi.org/10.1016/j.bioadv.2022.212952
[2022] Hip Function Was Not Associated with the Incidence of Preoperative Deep Vein Thrombosis in Patients Undergoing Primary Total Hip Arthroplasty.
DOI: https://doi.org/10.18926/amo/64039
[2022] Sagittal alignment in patients with flexion contracture of the hip before and after total hip arthroplasty
DOI: https://doi.org/10.1007/s00402-022-04606-y
[2022] Development of a rational framework for the therapeutic efficacy of fecal microbiota transplantation for calf diarrhea treatment
DOI: https://doi.org/10.1186/s40168-021-01217-4
[2022] Cholecystitis and Cholangitis during Continuous Renal Replacement Therapy in a Patient with Retroperitoneal Hemorrhage Requiring Large Amounts of Contrast Medium for the Assessment and Intervention
DOI: https://doi.org/10.2169/internalmedicine.8518-21
[2022] Ingestion of miso regulates immunological robustness in mice
DOI: https://doi.org/10.1371/journal.pone.0261680
[2022] Synergistic Effect of Sulfonation Followed Precipitation of Amorphous Calcium Phosphate on the Bone-Bonding Strength of Carbon-Fiber-Reinforced Peek
DOI: https://doi.org/10.2139/ssrn.4187561
[2021] Blister-like aneurysm of the anterior communicating artery treated with only Low-profile Visualized Intraluminal Support Junior stent
DOI: https://doi.org/10.25259/sni_923_2021
[2021] Inverted reamer technique for bone grafting of the acetabulum: technical note
DOI: https://doi.org/10.1186/s13018-021-02810-x
[2021] The degenerative changes of the sacroiliac joint after S2 alar-iliac screw placement
DOI: https://doi.org/10.3171/2021.4.spine202035
[2021] Uninterrupted Direct Oral Anticoagulants Without a Change in Regimen for Catheter Ablation for Atrial Fibrillation Is an Acceptable Protocol
DOI: https://doi.org/10.1253/circrep.cr-20-0139
[2021] A Novel Technique of Balloon Pulmonary Angioplasty for the Treatment of Total Occlusion Lesions
DOI: https://doi.org/10.1016/j.cjco.2021.07.009
[2021] Pseudo‐elevation of conduction system pacing threshold through parallel connection of an intracardiac electrogram recording system
DOI: https://doi.org/10.1111/jce.15129
[2021] Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study
DOI: https://doi.org/10.1007/s11357-021-00398-y
[2021] Decrease of α-defensin impairs intestinal metabolite homeostasis via dysbiosis in mouse chronic social defeat stress model
DOI: https://doi.org/10.1038/s41598-021-89308-y
[2021] Decrease of alpha-defensin impairs intestinal metabolite homeostasis via dysbiosis in mouse chronic social defeat stress model
[2021] Hyperperfusion and intracranial hemorrhage after burr hole surgery of chronic subdural hematoma
DOI: https://doi.org/10.25259/sni_306_2020
[2021] Ring enhanced aneurysm due to vasa vasorum of aneurysm wall mimicking a metastatic brain tumor
DOI: https://doi.org/10.25259/sni_582_2020
[2021] An Observational Survey of Nail and Skin of Spine Surgeons-Possible Damage by Occupational Ionizing Radiation Exposure
DOI: https://doi.org/10.22603/ssrr.2020-0204

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（50 件）

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