Masami Yokota Hirai 研究室

主宰者：Masami Yokota Hirai

理化学研究所・RIKEN Center for Sustainable Resource Science

AI 要約（直近 5 年の研究成果）

本研究室は、植物が生産する多様な化学物質（代謝産物）の全体像を解き明かし、それらがどのように作られ、機能しているのかを明らかにすることを目指しています。具体的には、質量分析法などの分析技術を用いて植物細胞内や根周辺の環境に存在する数百から数千の物質を同時に測定し、遺伝情報や遺伝子の発現パターンと組み合わせることで、物質生産の仕組みを解明しています。このアプローチにより、医療用途や食品の価値を高める機能性物質の効率的な生産方法の開発につながる知見を得ています。同時に、植物と周辺環境との相互作用にも注目しています。例えば、植物の根が土壌微生物と交わす化学的シグナルや、葉の気孔が内部組織からの信号に応答する仕組みを、代謝産物レベルで調査しています。さらに、特定の遺伝子を改変して目的の物質を効率よく生産する生物工学的手法や、複雑な遺伝子制御ネットワークをデータ解析で理解する計算生物学的手法も展開しており、植物科学と応用技術の両面から研究を進めています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（67 件）

[2026] Identification of an isoflavone 6-hydroxylase involved in tectorigenin biosynthesis in kudzu (Pueraria montana var. lobata) and the efficient production of 6-methoxyisoflavones
DOI: https://doi.org/10.5511/plantbiotechnology.26.0330b
[2026] Multi‐omics dissection of steviol glycoside synthesis reveals haplotype‐linked specialization of UGT76G genes in Stevia rebaudiana
DOI: https://doi.org/10.1111/nph.71191
[2026] Stable isotope–assisted computational mass spectrometry reveals root-specific alkaloids in Glycyrrhiza species
DOI: https://doi.org/10.64898/2026.05.05.722977
[2026] Integration of proxy intermediate omics traits into a nonlinear two-step model for accurate phenotypic prediction
DOI: https://doi.org/10.1007/s00122-026-05171-3
[2025] An Integrated Approach for the Comprehensive Characterization of Metabolites in Broccoli (Brassica oleracea var. Italica) by Liquid Chromatography High-Resolution Tandem Mass Spectrometry
DOI: https://doi.org/10.3390/plants14203223
[2025] Development of plant extracts as substrates for untargeted transporter substrate identification in Xenopus oocytes
DOI: https://doi.org/10.3389/fpls.2025.1640426
[2025] Apoplastic metabolomics reveals sugars as mesophyll messengers regulating guard cell ion transport under red light
DOI: https://doi.org/10.1038/s41477-025-02078-7
[2025] Solanoeclepin C, a root‐secreted molecule converted by rhizosphere microbes to hatching factors for potato cyst nematodes
DOI: https://doi.org/10.1111/nph.70252
[2025] I-SVVS: integrative stochastic variational variable selection to explore joint patterns of multi-omics microbiome data
DOI: https://doi.org/10.1093/bib/bbaf132
[2025] Loss-of-functional mutation in ANGUSTIFOLIA3 causes leucine hypersensitivity and hypoxia response during Arabidopsis thaliana seedling growth
DOI: https://doi.org/10.1007/s11306-025-02249-9

続きを表示（残り 57 件）

[2025] Metabolome Profiling and Predictive Modeling of Dark Green Leaf Trait in Bunching Onion Varieties
DOI: https://doi.org/10.3390/metabo15040226
[2025] Unelongated Stems are an Active Nitrogen-Fixing Site in Rice Stems Supported by Both Sugar and Methane Under Low Nitrogen Conditions
DOI: https://doi.org/10.1186/s12284-025-00757-9
[2025] Multiomics-based assessment of the impact of airflow on diverse plant callus cultures
DOI: https://doi.org/10.1038/s41597-025-04518-7
[2025] Metabolite Profiling and Association Analysis of Leaf Tipburn in Heat-Tolerant Bunching Onion Varieties
DOI: https://doi.org/10.3390/plants14020187
[2025] Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
DOI: https://doi.org/10.1002/1873-3468.70014
[2025] Spatial metabolomics as a new avenue in plant developmental biology: insights into serine biosynthesis during spermatogenesis in Marchantia polymorpha 
DOI: https://doi.org/10.1080/15592324.2025.2571669
[2024] The phosphorylated pathway of serine biosynthesis affects sperm, embryo, and sporophyte development, and metabolism in Marchantia polymorpha
DOI: https://doi.org/10.1038/s42003-023-05746-6
[2024] Plant metabolomics
DOI: https://doi.org/10.1093/jxb/erae047
[2024] Omics-based identification of the broader effects of 2-hydroxyisoflavanone synthase gene editing on a gene regulatory network beyond isoflavonoid loss in soybean hairy roots
DOI: https://doi.org/10.1093/pcp/pcae151
[2024] Retention order prediction of peptides containing non-proteinogenic amino acids
DOI: https://doi.org/10.1093/bioadv/vbaf246
[2024] Intestinal butyric acid-mediated disruption of gut hormone secretion and lipid metabolism in vasopressin receptor-deficient mice
DOI: https://doi.org/10.1016/j.molmet.2024.102072
[2024] Overexpression of BoSULTR1;1/BoSULTR1;2 promotes glucosinolate accumulation and enhances stress tolerance in broccoli
DOI: https://doi.org/10.1016/j.scienta.2024.113883
[2024] Multi-omics signatures of diverse plant callus cultures
[2024] Preface to the special issue “Synthetic Biology and Bioproduction in Plants”
DOI: https://doi.org/10.5511/plantbiotechnology.24.0000p
[2024] Multi-omics signatures of diverse plant callus cultures
DOI: https://doi.org/10.5511/plantbiotechnology.24.0719a
[2024] Distribution, biosynthesis, and synthetic biology of phenylethanoid glycosides in the order Lamiales
DOI: https://doi.org/10.5511/plantbiotechnology.24.0720a
[2024] Genomic view of heavy-ion-induced deletions associated with distribution of essential genes in Arabidopsis thaliana
DOI: https://doi.org/10.3389/fpls.2024.1352564
[2024] Widely targeted metabolomics reveals the species-specific, matureness-specific and post-harvest-specific discriminations in the chemical profiles of Vietnamese endemic golden camellias
DOI: https://doi.org/10.1111/ijfs.17071
[2024] Integration of cell differentiation and initiation of monoterpenoid indole alkaloid metabolism in seed germination of Catharanthus roseus
DOI: https://doi.org/10.1111/nph.19662
[2024] Reaction norm for genomic prediction of plant growth: modeling drought stress response in soybean
DOI: https://doi.org/10.1007/s00122-024-04565-5
[2024] N2‐Acetylornithine deacetylase functions as a <scp>Cys‐Gly</scp> dipeptidase in the cytosolic glutathione degradation pathway in Arabidopsis thaliana
DOI: https://doi.org/10.1111/tpj.16700
[2024] High-Throughput Phenotyping of Soybean Biomass: Conventional Trait Estimation and Novel Latent Feature Extraction Using UAV Remote Sensing and Deep Learning Models
DOI: https://doi.org/10.34133/plantphenomics.0244
[2023] An agroecological structure model of compost—soil—plant interactions for sustainable organic farming
DOI: https://doi.org/10.1038/s43705-023-00233-9
[2023] Distinct lactate metabolism between hepatocytes and myotubes revealed by live cell imaging with genetically encoded indicators
DOI: https://doi.org/10.1016/j.bbrc.2023.149416
[2023] Mitochondrial <scp>ATP</scp> concentration decreases immediately after glucose administration to glucose‐deprived hepatocytes
DOI: https://doi.org/10.1002/2211-5463.13744
[2023] Single‐grain‐based widely targeted metabolomics profiling of sixty‐four accessions of Japanese wild soybean ( Glycin soja Sieb. Et Zucc.)
DOI: https://doi.org/10.1111/ijfs.16654
[2023] The Roles of Functional Amino Acids in Plant Growth and Development
DOI: https://doi.org/10.1093/pcp/pcad071
[2023] Identification of a gene set that maintains tumorigenicity of the hepatocellular carcinoma cell line Li-7
DOI: https://doi.org/10.1007/s13577-023-00967-7
[2023] A metabolome genome-wide association study implicates histidine N-pi-methyltransferase as a key enzyme in N-methylhistidine biosynthesis in Arabidopsis thaliana
DOI: https://doi.org/10.3389/fpls.2023.1201129
[2023] Nsp14 of SARS-CoV-2 inhibits mRNA processing and nuclear export by targeting the nuclear cap-binding complex
DOI: https://doi.org/10.1093/nar/gkad483
[2023] Molecular Identification of UDP-Sugar-Dependent Glycosyltransferase and Acyltransferase Involved in the Phenylethanoid Glycoside Biosynthesis Induced by Methyl Jasmonate in Sesamum indicum L.
DOI: https://doi.org/10.1093/pcp/pcad053
[2023] A simple method for creating transgenic pea hairy roots using a Japanese pea cultivar and a Japanese Rhizobium radiobacter strain
DOI: https://doi.org/10.5511/plantbiotechnology.22.1219c
[2023] Roles of type II H+-PPases and PPsPase1/PECP2 in early developmental stages and PPi homeostasis of Arabidopsis thaliana
DOI: https://doi.org/10.3389/fpls.2023.1031426
[2023] Endoplasmic Reticulum Bodies in the Lateral Root Cap Are Involved in the Direct Transport of Beta-Glucosidase to Vacuoles
DOI: https://doi.org/10.1093/pcp/pcac177
[2022] Skotomorphogenesis exploits threonine to promote hypocotyl elongation
DOI: https://doi.org/10.1017/qpb.2022.19
[2022] Targeted Metabolome Profiling of Indonesian Shallots and Japanese Long-Day/Short-Day Bulb Onions
DOI: https://doi.org/10.3390/metabo12121260
[2022] Effects of irrigation on root growth and development of soybean: A 3-year sandy field experiment
DOI: https://doi.org/10.3389/fpls.2022.1047563
[2022] Heterologous biosynthesis of isobavachalcone in tobacco based on in planta screening of prenyltransferases
DOI: https://doi.org/10.3389/fpls.2022.1034625
[2022] Ethanol-Mediated Novel Survival Strategy against Drought Stress in Plants
DOI: https://doi.org/10.1093/pcp/pcac114
[2022] Tissue-targeted inorganic pyrophosphate hydrolysis in a fugu5 mutant reveals that excess inorganic pyrophosphate triggers developmental defects in a cell-autonomous manner
DOI: https://doi.org/10.3389/fpls.2022.945225
[2022] Glutathione degradation activity of <scp>γ‐glutamyl</scp> peptidase 1 manifests its dual roles in primary and secondary sulfur metabolism in Arabidopsis
DOI: https://doi.org/10.1111/tpj.15912
[2022] 植物二次代謝産物のリサイクル経路を発見
DOI: https://doi.org/10.1271/kagakutoseibutsu.60.264
[2022] Differential regulation of fluorescent alkaloid metabolism between idioblast and lacticifer cells during leaf development in Catharanthus roseus seedlings
DOI: https://doi.org/10.1007/s10265-022-01380-1
[2022] Tracking metabolites at single-cell resolution reveals metabolic dynamics during plant mitosis
DOI: https://doi.org/10.1093/plphys/kiac093
[2022] Assessment of Greenhouse Tomato Anthesis Rate Through Metabolomics Using LASSO Regularized Linear Regression Model
DOI: https://doi.org/10.3389/fmolb.2022.839051
[2022] Comparative Evaluation of Plasma Metabolomic Data from Multiple Laboratories
DOI: https://doi.org/10.3390/metabo12020135
[2021] Development of a <scp>Pteris vittata</scp> L. compound database by widely targeted metabolomics profiling
DOI: https://doi.org/10.1002/bmc.5110
[2021] Targeted permeabilization of the cell wall and extraction of charged molecules from single cells in intact plant clusters using a focused electric field
DOI: https://doi.org/10.1039/d0an02163f
[2021] Overexpression of nicotinamidase 3 (NIC3) gene and the exogenous application of nicotinic acid (NA) enhance drought tolerance and increase biomass in Arabidopsis
DOI: https://doi.org/10.1007/s11103-021-01179-z
[2021] Identification and characterization of glycosyltransferases catalyzing direct xanthone 4‐C‐glycosylation in Hypericum perforatum
DOI: https://doi.org/10.1002/1873-3468.14179
[2021] An auxin signaling network translates low-sugar-state input into compensated cell enlargement in the fugu5 cotyledon
DOI: https://doi.org/10.1371/journal.pgen.1009674
[2021] Retrograde sulfur flow from glucosinolates to cysteine in Arabidopsis thaliana
DOI: https://doi.org/10.1073/pnas.2017890118
[2021] Diversified amino acid-mediated allosteric regulation of phosphoglycerate dehydrogenase for serine biosynthesis in land plants
DOI: https://doi.org/10.1042/bcj20210191
[2021] Medicago sativa and Medicago truncatula Show Contrasting Root Metabolic Responses to Drought
DOI: https://doi.org/10.3389/fpls.2021.652143
[2021] Comprehensive Metabolite Profiling in Genetic Resources of Garlic (Allium sativum L.) Collected from Different Geographical Regions
DOI: https://doi.org/10.3390/molecules26051415
[2021] OryzaGenome2.1: Database of Diverse Genotypes in Wild Oryza Species
DOI: https://doi.org/10.1186/s12284-021-00468-x
[2021] Analysis of carbon flow at the metabolite level reveals that starch synthesis from hexose is a limiting factor in a high-yielding rice cultivar
DOI: https://doi.org/10.1093/jxb/erab016

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（67 件）

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