Makoto Arai 研究室

主宰者：Makoto Arai

東京大学

兼任：Tokyo Metropolitan Institute of Medical Science

AI 要約（直近 5 年の研究成果）

本研究室は、栄養代謝と精神神経疾患の関連性を、分子・遺伝学的レベルから個体レベルまで多角的に研究しています。特に、糖代謝と脂肪組織の形態変化の関係、冷熱ストレスと褐色脂肪組織の機能に関する遺伝的・後生的制御機構の解明に取り組んでいます。また、統合失調症など精神疾患の発症メカニズムとして、タンパク質糖化産物（後進糖化産物）や亜鉛欠乏といった末梢血中の生化学マーカーと疾患症状の関連性を調べており、患者由来の細胞モデルや動物モデルを用いた機構解析を行っています。研究手法としては、患者血清の生化学解析と臨床情報の統計解析を基盤としながら、マウスやショウジョウバエなどの動物モデルでの行動実験、原代神経細胞培養系での分子生物学的検討、脳画像解析（拡散テンソル撮影）など、多様なアプローチを組み合わせています。さらに、自然由来物質のスクリーニングによる疾患関連物質の生成抑制機構の探索も行っており、基礎研究から臨床応用につながる知見を創出することを目指しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

外部リンク

研究成果（106 件）

[2025] Pentosidine modification of neuronal proteins induces dendritic spine enlargement in vitro
DOI: https://doi.org/10.1016/j.bbrc.2025.153032
[2025] Glucose-activated JMJD1A drives visceral adipogenesis via α-ketoglutarate-dependent chromatin remodeling
DOI: https://doi.org/10.1016/j.celrep.2025.116060
[2025] Efficacy of a tip-tapered hood for diverticular bleeding with inflammation
DOI: https://doi.org/10.1016/j.ajg.2025.02.002
[2025] Pre-fertilization-origin preservation of brown fat-mediated energy expenditure in humans
DOI: https://doi.org/10.1038/s42255-025-01249-2
[2025] Association between plasma glucuronic acid levels and clinical features in schizophrenia
DOI: https://doi.org/10.1192/bjo.2025.20
[2025] Role of pentosidine accumulation in stress-induced social behavioral deficits
DOI: https://doi.org/10.1016/j.neulet.2025.138180
[2025] Glucose-activated JMJD1A drives visceral adipogenesis via α-ketoglutarate-dependent chromatin remodeling
DOI: https://doi.org/10.1016/j.celrep.2025.116060
[2025] Efficacy of a tip-tapered hood for diverticular bleeding with inflammation
DOI: https://doi.org/10.1016/j.ajg.2025.02.002
[2025] Schizophrenia with hypozincemia: Clinical features and symptom severity
DOI: https://doi.org/10.1016/j.schres.2025.10.013
[2025] Pre-fertilization-origin preservation of brown fat-mediated energy expenditure in humans
DOI: https://doi.org/10.1038/s42255-025-01249-2

続きを表示（残り 96 件）

[2025] Association between plasma glucuronic acid levels and clinical features in schizophrenia
DOI: https://doi.org/10.1192/bjo.2025.20
[2025] Role of pentosidine accumulation in stress-induced social behavioral deficits
DOI: https://doi.org/10.1016/j.neulet.2025.138180
[2025] Schizophrenia with hypozincemia: Clinical features and symptom severity
DOI: https://doi.org/10.1016/j.schres.2025.10.013
[2025] Distinct microRNA profiles in neuron-derived extracellular vesicles between recent-onset and chronic-phase schizophrenia
DOI: https://doi.org/10.1038/s41537-025-00706-x
[2024] Publication of Two Books : “Dictionary of Kampo Medicine-Basic terms” and “Complete Kampo Medicine (Japanese version)” and Future Plans
DOI: https://doi.org/10.3937/kampomed.75.257
[2024] Anthocyanins as potent inhibitors of pentosidine synthesis: Antioxidant-mediated effects
DOI: https://doi.org/10.1016/j.bbrc.2024.151007
[2024] Anthocyanins as potent inhibitors of pentosidine synthesis: Antioxidant-mediated effects
DOI: https://doi.org/10.1016/j.bbrc.2024.151007
[2024] Copy number variations in <scp>RNF216</scp> and postsynaptic membrane–associated genes are associated with bipolar disorder: a case‐control study in the Japanese population
DOI: https://doi.org/10.1111/pcn.13752
[2024] Amyloban, extracted from Hericium erinaceus , ameliorates social deficits and suppresses the enhanced dopaminergic system in social defeat stress mice
DOI: https://doi.org/10.1002/npr2.12480
[2024] Behavioral Dysfunctions Caused by Pyridoxamine Deficiency in Drosophila melanogaster
DOI: https://doi.org/10.3177/jnsv.70.252
[2024] Association of homocysteine with white matter dysconnectivity in schizophrenia
DOI: https://doi.org/10.1038/s41537-024-00458-0
[2024] Mitochondrial biogenesis in white adipose tissue mediated by JMJD1A-PGC-1 axis limits age-related metabolic disease
DOI: https://doi.org/10.1016/j.isci.2024.109398
[2024] Copy number variations in <scp>RNF216</scp> and postsynaptic membrane–associated genes are associated with bipolar disorder: a case‐control study in the Japanese population
DOI: https://doi.org/10.1111/pcn.13752
[2024] Amyloban, extracted from Hericium erinaceus , ameliorates social deficits and suppresses the enhanced dopaminergic system in social defeat stress mice
DOI: https://doi.org/10.1002/npr2.12480
[2024] Behavioral Dysfunctions Caused by Pyridoxamine Deficiency in Drosophila melanogaster
DOI: https://doi.org/10.3177/jnsv.70.252
[2024] Association of homocysteine with white matter dysconnectivity in schizophrenia
DOI: https://doi.org/10.1038/s41537-024-00458-0
[2024] Mitochondrial biogenesis in white adipose tissue mediated by JMJD1A-PGC-1 axis limits age-related metabolic disease
DOI: https://doi.org/10.1016/j.isci.2024.109398
[2024] Publication of Two Books : “Dictionary of Kampo Medicine-Basic terms” and “Complete Kampo Medicine (Japanese version)” and Future Plans
DOI: https://doi.org/10.3937/kampomed.75.257
[2023] Association between copy number variations in parkin (PRKN) and schizophrenia and autism spectrum disorder: A case–control study
DOI: https://doi.org/10.1002/npr2.12370
[2023] Three cases successfully treated with a combination of unkeito and boiogito for menopausal arthralgia
DOI: https://doi.org/10.1002/tkm2.1390
[2023] Glucuronic acid is a novel source of pentosidine, associated with schizophrenia
DOI: https://doi.org/10.1016/j.redox.2023.102876
[2023] A Novel Long Noncoding RNA in Osteocytes Regulates Bone Formation through the Wnt/β-Catenin Signaling Pathway
DOI: https://doi.org/10.3390/ijms241713633
[2023] Association between copy number variations in parkin (PRKN) and schizophrenia and autism spectrum disorder: A case–control study
DOI: https://doi.org/10.1002/npr2.12370
[2023] Three cases successfully treated with a combination of unkeito and boiogito for menopausal arthralgia
DOI: https://doi.org/10.1002/tkm2.1390
[2023] Glucuronic acid is a novel source of pentosidine, associated with schizophrenia
DOI: https://doi.org/10.1016/j.redox.2023.102876
[2023] A Novel Long Noncoding RNA in Osteocytes Regulates Bone Formation through the Wnt/β-Catenin Signaling Pathway
DOI: https://doi.org/10.3390/ijms241713633
[2023] Association between enhanced carbonyl stress and decreased apparent axonal density in schizophrenia by multimodal white matter imaging
DOI: https://doi.org/10.1038/s41598-023-39379-w
[2023] Structural aging of human neurons is opposite of the changes in schizophrenia
DOI: https://doi.org/10.1371/journal.pone.0287646
[2023] Association between enhanced carbonyl stress and decreased apparent axonal density in schizophrenia by multimodal white matter imaging
DOI: https://doi.org/10.1038/s41598-023-39379-w
[2023] Structural aging of human neurons is opposite of the changes in schizophrenia
DOI: https://doi.org/10.1371/journal.pone.0287646
[2023] #4598 ADMINISTRATION OF ASTRAGALUS MEMBRANACEUS IMPROVES RENAL CONDITIONS AND SERUM CARNOSINE LEVELS IN AN ACUTE KIDNEY INJURY MODEL
DOI: https://doi.org/10.1093/ndt/gfad063b_4598
[2023] Urinary exosomal microRNAs as predictive biomarkers for persistent psychotic-like experiences
DOI: https://doi.org/10.1038/s41537-023-00340-5
[2023] Urinary exosomal microRNAs as predictive biomarkers for persistent psychotic-like experiences
DOI: https://doi.org/10.1038/s41537-023-00340-5
[2023] #4598 ADMINISTRATION OF ASTRAGALUS MEMBRANACEUS IMPROVES RENAL CONDITIONS AND SERUM CARNOSINE LEVELS IN AN ACUTE KIDNEY INJURY MODEL
DOI: https://doi.org/10.1093/ndt/gfad063b_4598
[2022] Schizophrenia-Mimicking Layers Outperform Conventional Neural Network Layers
DOI: https://doi.org/10.3389/fnbot.2022.851471
[2022] MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis
DOI: https://doi.org/10.1038/s41467-022-33363-0
[2022] Plasma unconjugated bile acids as novel biomarker for schizophrenia
DOI: https://doi.org/10.1016/j.bbrc.2022.09.110
[2022] Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder
DOI: https://doi.org/10.1016/j.biopsych.2022.04.003
[2022] Hair zinc levels and psychosis risk among adolescents
DOI: https://doi.org/10.1038/s41537-022-00307-y
[2022] The development and clinical application of a novel schizophrenia screening system using yoga-induced autonomic nervous system responses
DOI: https://doi.org/10.3389/fphys.2022.902979
[2022] Plasma unconjugated bile acids as novel biomarker for schizophrenia
DOI: https://doi.org/10.1016/j.bbrc.2022.09.110
[2022] The development and clinical application of a novel schizophrenia screening system using yoga-induced autonomic nervous system responses
DOI: https://doi.org/10.3389/fphys.2022.902979
[2022] MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis
DOI: https://doi.org/10.1038/s41467-022-33363-0
[2022] Carbonyl stress-sensitive brain regions in the patient with treatment-resistant schizophrenia with a glyoxalase 1 frameshift mutation: Autopsy study
DOI: https://doi.org/10.1016/j.psycr.2022.100064
[2022] X chromosome aneuploidies and schizophrenia: association analysis and phenotypic characterization
DOI: https://doi.org/10.1111/pcn.13474
[2022] Cross-disorder analysis of genic and regulatory copy number variants in bipolar disorder, schizophrenia, and autism spectrum disorder.
[2022] Carbonyl stress-sensitive brain regions in the patient with treatment-resistant schizophrenia with a glyoxalase 1 frameshift mutation: Autopsy study
DOI: https://doi.org/10.1016/j.psycr.2022.100064
[2022] X chromosome aneuploidies and schizophrenia: association analysis and phenotypic characterization
DOI: https://doi.org/10.1111/pcn.13474
[2022] Cross-disorder analysis of genic and regulatory copy number variants in bipolar disorder, schizophrenia, and autism spectrum disorder.
[2022] Exonic deletions in IMMP2L in schizophrenia with enhanced glycation stress subtype
DOI: https://doi.org/10.1371/journal.pone.0270506
[2022] Improving polygenic prediction in ancestrally diverse populations
DOI: https://doi.org/10.1038/s41588-022-01054-7
[2022] Role of advanced glycation end products in the longitudinal association between muscular strength and psychotic symptoms among adolescents
DOI: https://doi.org/10.1038/s41537-022-00249-5
[2022] Exonic deletions in IMMP2L in schizophrenia with enhanced glycation stress subtype
DOI: https://doi.org/10.1371/journal.pone.0270506
[2022] Improving polygenic prediction in ancestrally diverse populations
DOI: https://doi.org/10.1038/s41588-022-01054-7
[2022] Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder
DOI: https://doi.org/10.1016/j.biopsych.2022.04.003
[2022] Schizophrenia-Mimicking Layers Outperform Conventional Neural Network Layers
DOI: https://doi.org/10.3389/fnbot.2022.851471
[2022] Near-Infrared Time-Resolved Spectroscopy Shows Anterior Prefrontal Blood Volume Reduction in Schizophrenia but Not in Major Depressive Disorder
DOI: https://doi.org/10.3390/s22041594
[2022] Near-Infrared Time-Resolved Spectroscopy Shows Anterior Prefrontal Blood Volume Reduction in Schizophrenia but Not in Major Depressive Disorder
DOI: https://doi.org/10.3390/s22041594
[2022] Molecular mechanism of schizophrenia-like behavioral deficits induced by methylglyoxal detoxification impairments
DOI: https://doi.org/10.1254/jpssuppl.96.0_1-b-p-026
[2022] Molecular mechanism of schizophrenia-like behavioral deficits induced by methylglyoxal detoxification impairments
DOI: https://doi.org/10.1254/jpssuppl.96.0_1-b-p-026
[2021] AKR1A1 Variant Associated With Schizophrenia Causes Exon Skipping, Leading to Loss of Enzymatic Activity
DOI: https://doi.org/10.3389/fgene.2021.762999
[2021] GH-induced LH hyporesponsiveness as a potential mechanism for hypogonadism in male patients with acromegaly
DOI: https://doi.org/10.1507/endocrj.ej20-0596
[2021] Structure of pathological TDP-43 filaments from ALS with FTLD
DOI: https://doi.org/10.1038/s41586-021-04199-3
[2021] AKR1A1 Variant Associated With Schizophrenia Causes Exon Skipping, Leading to Loss of Enzymatic Activity
DOI: https://doi.org/10.3389/fgene.2021.762999
[2021] Psychotic experiences predict subsequent loneliness among adolescents: A population-based birth cohort study
DOI: https://doi.org/10.1016/j.schres.2021.11.031
[2021] Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis
DOI: https://doi.org/10.1038/s41467-021-27321-5
[2021] High-sucrose diets contribute to brain angiopathy with impaired glucose uptake and psychosis-related higher brain dysfunctions in mice
DOI: https://doi.org/10.1126/sciadv.abl6077
[2021] Psychotic experiences predict subsequent loneliness among adolescents: A population-based birth cohort study
DOI: https://doi.org/10.1016/j.schres.2021.11.031
[2021] Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis
DOI: https://doi.org/10.1038/s41467-021-27321-5
[2021] High-sucrose diets contribute to brain angiopathy with impaired glucose uptake and psychosis-related higher brain dysfunctions in mice
DOI: https://doi.org/10.1126/sciadv.abl6077
[2021] Fingertip advanced glycation end products and psychotic symptoms among adolescents
DOI: https://doi.org/10.1038/s41537-021-00167-y
[2021] Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex
DOI: https://doi.org/10.1016/j.redox.2021.102057
[2021] Fingertip advanced glycation end products and psychotic symptoms among adolescents
DOI: https://doi.org/10.1038/s41537-021-00167-y
[2021] Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex
DOI: https://doi.org/10.1016/j.redox.2021.102057
[2021] Brain capillary structures of schizophrenia cases and controls show a correlation with their neuron structures
DOI: https://doi.org/10.1038/s41598-021-91233-z
[2021] Dysregulation of post-transcriptional modification by copy number variable microRNAs in schizophrenia with enhanced glycation stress
DOI: https://doi.org/10.1038/s41398-021-01460-1
[2021] Structural diverseness of neurons between brain areas and between cases
DOI: https://doi.org/10.1038/s41398-020-01173-x
[2021] Brain capillary structures of schizophrenia cases and controls show a correlation with their neuron structures
DOI: https://doi.org/10.1038/s41598-021-91233-z
[2021] Dysregulation of post-transcriptional modification by copy number variable microRNAs in schizophrenia with enhanced glycation stress
DOI: https://doi.org/10.1038/s41398-021-01460-1
[2021] Advanced glycation end products and cognitive impairment in schizophrenia
DOI: https://doi.org/10.1371/journal.pone.0251283
[2021] Vitamin B6 deficiency hyperactivates the noradrenergic system, leading to social deficits and cognitive impairment
DOI: https://doi.org/10.1038/s41398-021-01381-z
[2021] Stable Serum Potassium After Intracerebral Hemorrhage Is Predictive of Primary Aldosteronism
DOI: https://doi.org/10.1210/jendso/bvab048.607
[2021] MO342ADMINISTRATION OF ASTRAGALUS MEMBRANACEUS PREVENTED CISPLATIN-INDUCED AKI, ESPECIALLY IN OLD MICE
DOI: https://doi.org/10.1093/ndt/gfab084.0015
[2021] Advanced glycation end products and cognitive impairment in schizophrenia
DOI: https://doi.org/10.1371/journal.pone.0251283
[2021] Vitamin B6 deficiency hyperactivates the noradrenergic system, leading to social deficits and cognitive impairment
DOI: https://doi.org/10.1038/s41398-021-01381-z
[2021] Stable Serum Potassium After Intracerebral Hemorrhage Is Predictive of Primary Aldosteronism
DOI: https://doi.org/10.1210/jendso/bvab048.607
[2021] MO342ADMINISTRATION OF ASTRAGALUS MEMBRANACEUS PREVENTED CISPLATIN-INDUCED AKI, ESPECIALLY IN OLD MICE
DOI: https://doi.org/10.1093/ndt/gfab084.0015
[2021] Accumulation of Carbonyl Proteins in the Brain of Mouse Model for Methylglyoxal Detoxification Deficits
DOI: https://doi.org/10.3390/antiox10040574
[2021] Problèmes juridiques relatifs au tatouage au Japon
DOI: https://doi.org/10.15027/50649
[2021] Cooperation of LIM domain‐binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia
DOI: https://doi.org/10.15252/emmm.202012574
[2021] Accumulation of Carbonyl Proteins in the Brain of Mouse Model for Methylglyoxal Detoxification Deficits
DOI: https://doi.org/10.3390/antiox10040574
[2021] Problèmes juridiques relatifs au tatouage au Japon
DOI: https://doi.org/10.15027/50649
[2021] Cooperation of LIM domain‐binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia
DOI: https://doi.org/10.15252/emmm.202012574
[2021] Structural diverseness of neurons between brain areas and between cases
DOI: https://doi.org/10.1038/s41398-020-01173-x
[2021] GH-induced LH hyporesponsiveness as a potential mechanism for hypogonadism in male patients with acromegaly
DOI: https://doi.org/10.1507/endocrj.ej20-0596
[2021] Structure of pathological TDP-43 filaments from ALS with FTLD
DOI: https://doi.org/10.1038/s41586-021-04199-3

科研費（0 件）

まだデータがありません（KAKEN 取り込み後に表示）。

所属学会・役職（0 件）

まだデータがありません（学会データ連携後に表示）。

AI 要約（直近 5 年の研究成果）

外部リンク

関連研究室(8 件)

研究成果（106 件）

科研費（0 件）

所属学会・役職（0 件）