Takamitsu Hosoya 研究室

主宰者：Takamitsu Hosoya

理化学研究所・RIKEN Center for Biosystems Dynamics Research

AI 要約（直近 5 年の研究成果）

本研究室は、有機化学と分析化学の融合を通じて、医療応用と物質開発に貢献する研究を展開しています。主要な研究対象は、芳香族化合物の合成化学と、生体内で機能する分子プローブの開発です。特に、遷移金属触媒反応やフォトケミストリーを活用した新規有機合成法の開発に注力しており、複雑な分子構造の効率的な構築を可能にする方法論を追求しています。合成化学の領域では、ニッケル触媒反応やアリーン（反応性に富む芳香族中間体）を利用した炭素骨格の構築法を研究しています。これらの反応系では、機械学習を用いた反応の定量的解析により、どのような分子特性が反応効率を支配するかを明らかにしています。また、医療診断・治療への応用を目指し、放射性同位体で標識した小分子プローブやナノクラスターの開発も進めており、がん診断やタンパク質修飾への利用を検討しています。さらに生物学的課題への対応として、リン脂質代謝やニューロトランスミッター経路に関わる生理活性物質の設計・合成にも取り組んでおり、基礎研究から医療応用まで、幅広いスケールで有機化学の価値を追求しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（60 件）

[2026] Machine-learning-guided screening of organic photosensitizers accelerated by domain adaptation
DOI: https://doi.org/10.1016/j.xcrp.2026.103141
[2026] Cross Cyclotrimerization of Arynes
DOI: https://doi.org/10.26434/chemrxiv.15004261/v1
[2026] Benzophenone-mediated deconstructive cross-coupling of secondary alcohols with data-driven mechanistic insights
DOI: https://doi.org/10.26434/chemrxiv.15002180/v1
[2026] Singlet-Oxygen-Driven C(sp 2 )–P Bond Cleavage Enables Red-Light Uncaging of Phosphorus(V) Prodrugs on Gold Nanoclusters
DOI: https://doi.org/10.1021/jacs.6c00254
[2025] Use of ArB(Epin)s as precursors for copper-mediated radiofluorination
DOI: https://doi.org/10.1016/j.nucmedbio.2025.109187
[2025] Machine-learning-guided screening of organic photosensitizers accelerated by domain adaptation
DOI: https://doi.org/10.26434/chemrxiv-2025-f0f3v
[2025] Claudin 5-binding small molecule transiently opens the blood-brain barrier and safely enhances brain drug delivery
DOI: https://doi.org/10.1016/j.jconrel.2025.114314
[2025] Upgrade of two-dimensional scintillation neutron detectors for single crystal diffractometer SENJU at J-PARC MLF
DOI: https://doi.org/10.1088/1742-6596/3130/1/012002
[2025] Discovery and development of an oral analgesic targeting the α2B adrenoceptor
DOI: https://doi.org/10.1073/pnas.2500006122
[2025] Temperature vaulting: A method for screening of slow- and tight-binding inhibitors that selectively target kinases in their non-native state
DOI: https://doi.org/10.1016/j.ejmech.2025.117789

続きを表示（残り 50 件）

[2025] Red‐light Emitting Orthogonally Trireactive Gold Nanoclusters for the Synthesis of Multifunctionalized Nanomaterials (Small 17/2025)
DOI: https://doi.org/10.1002/smll.202570131
[2025] Boronate Formation-Triggered Azide–Alkyne Cycloaddition
DOI: https://doi.org/10.1021/acs.orglett.5c00732
[2025] Synthesis of multisubstituted naphthalenes through consecutive aryne reactions
DOI: https://doi.org/10.1093/bulcsj/uoaf001
[2025] Photoirradiation-Promoted ipso -Azidation of 1-Aryltriazenes
DOI: https://doi.org/10.1021/acs.orglett.5c03938
[2025] Photoirradiation-Promoted ipso-Azidation of 1-Aryltriazenes
[2024] Molecular Design and Synthetic Strategy toward Development of PET Probes
DOI: https://doi.org/10.5059/yukigoseikyokaishi.82.433
[2024] 1,3-Butadiynyl sulfide-based compact trialkyne platform molecule for sequential assembly of three azides
DOI: https://doi.org/10.1039/d4cc05205f
[2024] Red‐light Emitting Orthogonally Trireactive Gold Nanoclusters for the Synthesis of Multifunctionalized Nanomaterials
DOI: https://doi.org/10.1002/smll.202408747
[2024] Revisiting the Synthetic Utility of 4,5‐Dehydro[2.2]paracyclophane
DOI: https://doi.org/10.1002/adsc.202400986
[2024] Detector Performances of Large Area Scintillator / Wavelength Shifting Fiber Neutron Detectors for SENJU Upgrade at J-PARC MLF
DOI: https://doi.org/10.1109/nss/mic/rtsd57108.2024.10654873
[2024] Chemical inhibition of phosphatidylcholine biogenesis reveals its role in mitochondrial division
DOI: https://doi.org/10.1016/j.isci.2024.109189
[2023] Clickable bisreactive small gold nanoclusters for preparing multifunctionalized nanomaterials: application to photouncaging of an anticancer molecule
DOI: https://doi.org/10.1039/d3sc04365g
[2023] Palladium-Catalyzed ipso-Borylation of Aryl Halides Promoted by Lewis Acid-Mediated Electrophilic Activation of Aryl(halo)palladium(II) Complex
DOI: https://doi.org/10.1021/acs.orglett.3c03531
[2023] Detector upgrade for SENJU neutron diffractometer at J-PARC MLF
DOI: https://doi.org/10.1109/nssmicrtsd49126.2023.10337865
[2023] Synthesis of Multisubstituted Aromatics via 3-Triazenylarynes
DOI: https://doi.org/10.1021/acs.orglett.3c02615
[2023] 11 C‐Cyanation of Aryl Fluorides via Nickel and Lithium Chloride‐Mediated C−F Bond Activation
DOI: https://doi.org/10.1002/anie.202302956
[2023] 11 C‐Cyanation of Aryl Fluorides via Nickel and Lithium Chloride‐Mediated C−F Bond Activation
DOI: https://doi.org/10.1002/ange.202302956
[2023] Acute nicotine exposure blocks aromatase in the limbic brain of healthy women: A [11C]cetrozole PET study
DOI: https://doi.org/10.1016/j.comppsych.2023.152381
[2023] Synthesis of 11C-Radiolabeled Eribulin as a Companion Diagnostics PET Tracer for Brain Glioblastoma
DOI: https://doi.org/10.1246/bcsj.20220335
[2023] Migrative Thioamination of Aryne Intermediates Generated from o-Iodoaryl Triflates
DOI: https://doi.org/10.1055/a-2030-6299
[2023] Synthesis of benzo[b]furans from alkynyl sulfoxides and phenols by the interrupted Pummerer reaction
DOI: https://doi.org/10.1039/d2ra07856b
[2022] Clinical evaluation of [18F]pitavastatin for quantitative analysis of hepatobiliary transporter activity
DOI: https://doi.org/10.1016/j.dmpk.2022.100449
[2022] Modular synthesis of triazoles from 2-azidoacrylamides having a nucleophilic amino group
DOI: https://doi.org/10.1039/d2ob00151a
[2022] Azido-type-selective triazole formation by iridium-catalyzed cycloaddition with thioalkynes
DOI: https://doi.org/10.1039/d2cc01739c
[2022] Substitution of α-Azido Sulfones with Thiolates to Form α-Azido Sulfides
DOI: https://doi.org/10.1021/acs.orglett.2c02895
[2022] Hydride reduction of o-(fluorosilyl)benzodifluorides for subsequent C–F transformations
DOI: https://doi.org/10.1039/d1cc06761c
[2022] Synthesis of Functionalized Dibenzoazacyclooctynes by a Decomplexation Method for Dibenzo-Fused Cyclooctyne–Cobalt Complexes
DOI: https://doi.org/10.1021/acs.orglett.2c03832
[2022] Reverse mutants of the catalytic 19 kDa mutant protein (nanoKAZ/nanoLuc) from Oplophorus luciferase with coelenterazine as preferred substrate
DOI: https://doi.org/10.1371/journal.pone.0272992
[2022] Red light-induced conjugation of amines through amide bond formation triggered via photooxidation of 3-acylindolizines
DOI: https://doi.org/10.1038/s42004-022-00712-5
[2022] Computational Study for Amino Acid Production from Carboxylic Acid via 14C β-decay
DOI: https://doi.org/10.7566/jpsj.91.064301
[2022] Synthesis of Multisubstituted Benzenes from Phenols via Multisubstituted Benzynes
DOI: https://doi.org/10.1055/a-1834-2927
[2022] Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY
DOI: https://doi.org/10.1016/j.pep.2022.106089
[2021] Chiral deaza-coelenterazine analogs for probing a substrate-binding site in the Ca2+-binding photoprotein aequorin
DOI: https://doi.org/10.1371/journal.pone.0251743
[2021] Identification of a chemical chaperone for mitigating protein aggregation and proteotoxicity during endoplasmic reticulum stress
DOI: https://doi.org/10.1096/fasebj.2021.35.s1.01505
[2021] Palladium-Catalyzed Sulfinylation of Aryl- and Alkenylborons with Sulfinate Esters
DOI: https://doi.org/10.1021/acs.orglett.1c01292
[2021] Transition-Metal-Free Synthesis of N-Arylphenothiazines through an N- and S-Arylation Sequence
DOI: https://doi.org/10.1021/acs.orglett.1c00515
[2021] Acylalkylation of Arynes Generated from o-Iodoaryl Triflates with Hydrosilanes and Cesium Fluoride
DOI: https://doi.org/10.1021/acs.orglett.1c00279
[2021] S1PR3–G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation
DOI: https://doi.org/10.1016/j.chembiol.2021.01.004
[2021] Nucleophilic transformations of azido-containing carbonyl compounds via protection of the azido group
DOI: https://doi.org/10.1039/d1cc01143j
[2021] Convergent Synthesis of Fluoroalkenes Using a Dual-Reactive Unit
DOI: https://doi.org/10.1021/acs.joc.0c02474
[2021] Diverse diaryl sulfide synthesis through consecutive aryne reactions
DOI: https://doi.org/10.1039/d0cc08373a
[2021] Facile Synthetic Methods for Diverse N-Arylphenylalanine Derivatives via Transformations of Aryne Intermediates and Cross-Coupling Reactions
DOI: https://doi.org/10.1246/bcsj.20210149
[2021] Formation of Coelenteramine from 2‐Peroxycoelenterazine in the Ca2+‐Binding Photoprotein Aequorin
DOI: https://doi.org/10.1111/php.13590
[2021] Lewis acid-mediated Suzuki–Miyaura cross-coupling reaction
DOI: https://doi.org/10.1038/s41929-021-00719-6
[2021] PET imaging of brain aromatase in humans and rhesus monkeys by 11C-labeled cetrozole analogs
DOI: https://doi.org/10.1038/s41598-021-03063-8
[2021] Enzymatic conversion of dehydrocoelenterazine to coelenterazine using FMN-bound flavin reductase of NAD(P)H:FMN oxidoreductase
DOI: https://doi.org/10.1016/j.bbrc.2021.11.089
[2021] 3-Azidoarynes: Generation and Regioselective Reactions
DOI: https://doi.org/10.1246/cl.210632
[2021] Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A
DOI: https://doi.org/10.1016/j.ejmech.2021.113948
[2021] Direct 3-Acylation of Indolizines by Carboxylic Acids for the Practical Synthesis of Red Light-Releasable Caged Carboxylic Acids
DOI: https://doi.org/10.1021/acs.joc.1c01244
[2021] Thioxanthone Synthesis from Benzoic Acid Esters through Directed ortho-Lithiation
DOI: https://doi.org/10.1246/cl.210293

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AI 要約（直近 5 年の研究成果）

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研究成果（60 件）

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