Takayuki Morisaki 研究室

主宰者：Takayuki Morisaki

東京大学

AI 要約（直近 5 年の研究成果）

当研究室は、大規模生物銀行や医学データベースを活用したゲノム解析を通じて、複雑な疾患の遺伝的背景を明らかにする研究を行っています。数万から数十万人規模の患者・対照者データに対してゲノム全体を調査する統計遺伝学的手法を適用し、特定の遺伝的変異がどのような疾患や臨床特性と関連しているかを同定しています。研究の主要なテーマは、がんや代謝疾患、心血管疾患、免疫関連疾患など多岐にわたっています。例えば、放射線治療と加齢に関連する遺伝現象の関係、血液中の代謝物質レベルを決定する遺伝因子、妊娠喪失や血管攣縮性狭心症などの疾患感受性遺伝子を調査しています。さらに、異なる祖先背景を持つ集団間での遺伝的効果の共通性と相違性を比較することで、医学的知見の一般化可能性を検証する国際的な共同研究も実施しています。これらの研究を通じて、遺伝的素因に基づいた個別化医療の実現や、疾患リスク予測の精度向上に貢献する基礎知見を蓄積しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（41 件）

[2025] Dissecting cross-population polygenic heterogeneity across respiratory and cardiometabolic diseases
DOI: https://doi.org/10.1038/s41467-025-58149-y
[2025] A variant in HMMR/HMMR-AS1 is associated with serum alanine aminotransferase levels in the Ryukyu population
DOI: https://doi.org/10.1038/s41598-025-90195-w
[2025] Local radiotherapy for cancer patients is associated with mosaic loss of chromosome Y, a hallmark of male aging
DOI: https://doi.org/10.1038/s41514-025-00261-w
[2025] Genetic Architecture of Circulating Metabolic Biomarkers Across Ancestral Populations
DOI: https://doi.org/10.64898/2025.12.03.25341540
[2025] Table S3 from ENIGMA CHEK2gether Project: A Comprehensive Study Identifies Functionally Impaired CHEK2 Germline Missense Variants Associated with Increased Breast Cancer Risk
DOI: https://doi.org/10.1158/1078-0432.30709710
[2025] Table S1 from ENIGMA CHEK2gether Project: A Comprehensive Study Identifies Functionally Impaired CHEK2 Germline Missense Variants Associated with Increased Breast Cancer Risk
DOI: https://doi.org/10.1158/1078-0432.30709722
[2025] Supplementary Methods 1 from ENIGMA CHEK2gether Project: A Comprehensive Study Identifies Functionally Impaired CHEK2 Germline Missense Variants Associated with Increased Breast Cancer Risk
DOI: https://doi.org/10.1158/1078-0432.30709725
[2025] Table S2 from ENIGMA CHEK2gether Project: A Comprehensive Study Identifies Functionally Impaired CHEK2 Germline Missense Variants Associated with Increased Breast Cancer Risk
DOI: https://doi.org/10.1158/1078-0432.30709716
[2024] Common and rare genetic variants predisposing females to unexplained recurrent pregnancy loss
DOI: https://doi.org/10.1038/s41467-024-49993-5
[2024] RNF213 Variants, Vasospastic Angina, and Risk of Fatal Myocardial Infarction
DOI: https://doi.org/10.1001/jamacardio.2024.1483

続きを表示（残り 31 件）

[2024] Interpretation and classification of FBN1 variants associated with Marfan syndrome: consensus recommendations from the Clinical Genome Resource’s FBN1 variant curation expert panel
DOI: https://doi.org/10.1186/s13073-024-01423-3
[2024] Genetic Risk Stratification of Primary Open-Angle Glaucoma in Japanese Individuals
DOI: https://doi.org/10.1016/j.ophtha.2024.05.026
[2023] JCS/JSCVS/JATS/JSVS 2020 Guideline on Diagnosis and Treatment of Aortic Aneurysm and Aortic Dissection
DOI: https://doi.org/10.1253/circj.cj-22-0794
[2023] Genome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals
DOI: https://doi.org/10.1038/s42003-023-04491-0
[2023] East Asian-specific and cross-ancestry genome-wide meta-analyses provide mechanistic insights into peptic ulcer disease
DOI: https://doi.org/10.1038/s41588-023-01569-7
[2023] AMPD2 plays important roles in regulating hepatic glucose and lipid metabolism
DOI: https://doi.org/10.1016/j.mce.2023.112039
[2023] Detection of trait-associated structural variations using short-read sequencing
DOI: https://doi.org/10.1016/j.xgen.2023.100328
[2023] Mobile element variation contributes to population-specific genome diversification, gene regulation and disease risk
DOI: https://doi.org/10.1038/s41588-023-01390-2
[2023] Genetic association analysis of 77,539 genomes reveals rare disease etiologies
DOI: https://doi.org/10.1038/s41591-023-02211-z
[2023] Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes
DOI: https://doi.org/10.1038/s43856-022-00231-3
[2022] Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity
DOI: https://doi.org/10.1016/j.xgen.2022.100212
[2022] Multi-trait and cross-population genome-wide association studies across autoimmune and allergic diseases identify shared and distinct genetic component
DOI: https://doi.org/10.1136/annrheumdis-2022-222460
[2022] Long-term durability of a reimplantation valve-sparing aortic root replacement can be expected in both Marfan syndrome and Loeys-Dietz syndrome
DOI: https://doi.org/10.1093/ejcts/ezac050
[2022] Genetic analysis of right heart structure and function in 40,000 people
DOI: https://doi.org/10.1038/s41588-022-01090-3
[2022] Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores
DOI: https://doi.org/10.1038/s41588-022-01036-9
[2022] Decoding the diversity of killer immunoglobulin-like receptors by deep sequencing and a high-resolution imputation method
DOI: https://doi.org/10.1016/j.xgen.2022.100101
[2022] Detailed Analysis of the Impact of Clonal Hematopoiesis on the Risk of Severe COVID-19 Infection
DOI: https://doi.org/10.1182/blood-2022-160436
[2021] Susceptibility loci and polygenic architecture highlight population specific and common genetic features in inguinal hernias
DOI: https://doi.org/10.1016/j.ebiom.2021.103532
[2021] Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis
DOI: https://doi.org/10.1038/s41591-021-01411-9
[2021] Leveraging supervised learning for functionally informed fine-mapping of cis-eQTLs identifies an additional 20,913 putative causal eQTLs
DOI: https://doi.org/10.1038/s41467-021-23134-8
[2021] Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection
DOI: https://doi.org/10.1038/s41591-021-01371-0
[2021] Genetic analyses identify widespread sex-differential participation bias
DOI: https://doi.org/10.1038/s41588-021-00846-7
[2021] Esm1 and Stc1 as Angiogenic Factors Responsible for Protective Actions of Adipose-Derived Stem Cell Sheets on Chronic Heart Failure After Rat Myocardial Infarction
DOI: https://doi.org/10.1253/circj.cj-20-0877
[2021] Surgical Outcome and Histological Differences between Individuals with TGFBR1 and TGFBR2 Mutations in Loeys-Dietz Syndrome
DOI: https://doi.org/10.5761/atcs.oa.20-00223
[2021] Association of protein tyrosine phosphatase 1B gene polymorphism with the effects of weight reduction therapy on bodyweight and glycolipid profiles in obese patients
DOI: https://doi.org/10.1111/jdi.13492
[2021] Clinical and molecular features of 66 patients with musculocontractural Ehlers−Danlos syndrome caused by pathogenic variants in CHST14 (mcEDS-CHST14)
DOI: https://doi.org/10.1136/jmedgenet-2020-107623
[2021] Genome-wide association study of colorectal polyps identified highly overlapping polygenic architecture with colorectal cancer
DOI: https://doi.org/10.1038/s10038-021-00980-4
[2021] Mutational and clinical spectrum of Japanese patients with hereditary hemorrhagic telangiectasia
DOI: https://doi.org/10.1186/s12920-021-01139-y
[2021] Loeys-Dietz Cardiomyopathy? Long-term Follow-up After Onset of Acute Decompensated Heart Failure
DOI: https://doi.org/10.1016/j.cjca.2021.11.010
[2021] Abstract 13700: Combined Landscape of Single-Nucleotide Variants and Copy-Number Alterations in Clonal Hematopoiesis and Their Impact on Hematological and Cardiovascular Outcomes
DOI: https://doi.org/10.1161/circ.144.suppl_1.13700
[2021] Mouse Model of Loeys–Dietz Syndrome Shows Elevated Susceptibility to Periodontitis via Alterations in Transforming Growth Factor-Beta Signaling
DOI: https://doi.org/10.3389/fphys.2021.715687

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AI 要約（直近 5 年の研究成果）

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研究成果（41 件）

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