Kazuhiro Irie 研究室

主宰者：Kazuhiro Irie

京都大学

AI 要約（直近 5 年の研究成果）

Kazuhiro Irie 研究室は、天然由来の生理活性物質とそれらの合成類似体を用いて、タンパク質と分子の相互作用を解明する研究を展開しています。特に、タンパク質キナーゼC（PKC）という酵素の活性制御に関心を持ち、海洋由来の毒性物質や微生物代謝産物など、様々な天然物をPKCのリガンド（結合分子）として機能させる仕組みを調べています。これらの研究では、化学合成によって天然物の構造を簡略化した類似体を設計・製造し、細胞実験や生化学的解析を通じてPKC結合能や生物活性を評価しています。同時に、アルツハイマー病の病態解明にも取り組んでいます。脳に蓄積するアミロイドベータというタンパク質が凝集する過程と、その神経毒性を可視化・測定する手法を開発しており、患者の脳組織を対象とした分析も実施しています。また、食物由来のポリフェノールなど生理活性物質がアミロイドベータの凝集を抑制する機構についても検討しており、これが将来的な疾患予防につながる知見として位置づけられています。加えて、天然物に含まれる多様な有機化合物から医学応用の可能性を持つ分子を探索する研究も行っています。骨粗鬆症やアレルギー炎症などの対象疾患に対して、伝統医学で用いられてきた植物抽出物から活性成分を単離し、その作用メカニズムを現代的な生化学手法で解析する取り組みが含まれます。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（50 件）

[2026] Structural optimization of 3,4-dihydroquinolizinium ring toward practical application for chemo-selective modification of cysteine
DOI: https://doi.org/10.1016/j.tchem.2026.100155
[2026] Isolation and characterization of blastmycetin G, a sofa-conformation fixed analog of teleocidin B’s, produced by Streptomyces blastmyceticus
DOI: https://doi.org/10.1093/bbb/zbag044
[2025] Synthesis of Unnatural Aplysiatoxin Analogs with High Affinity for Protein Kinase C
DOI: https://doi.org/10.1002/ejoc.202500890
[2025] 3,4‐Dihydroquinolizinium Ring, the Core Structure of Quinocidin, as a Cysteine‐Selective Electrophile
DOI: https://doi.org/10.1002/cplu.202500149
[2025] Isolation of Allosteric Tryptase Inhibitor from Methanol Extract of Rhubarb and Enhancement of Its Tryptase Inhibitory Activity by Compounds That Were Screened by In Silico Screening
DOI: https://doi.org/10.3390/molecules30061341
[2025] Identification of the binding site and immunoreactivity of anti-Aβ antibody 11A1: Comparison with the toxic conformation-specific TxCo-1 antibody
DOI: https://doi.org/10.1016/j.bbrc.2025.151655
[2025] Validation of machine learning-assisted screening of PKC ligands: PKC binding affinity and activation
DOI: https://doi.org/10.1093/bbb/zbaf008
[2025] Sizes of amyloid-β oligomers predicted using atomic force microscopy and two-point crosslinked dimers as standards
DOI: https://doi.org/10.1039/d5cc00856e
[2025] Synthetic Studies of Spiroschincarins: Construction of 1-Oxaspiro[6.6]tridecanone Skeleton with All-cis Cyclopropane Moiety
DOI: https://doi.org/10.1021/acs.orglett.5c03325
[2024] Effect of phenolic-hydroxy-group incorporation on the biological activity of a simplified aplysiatoxin analog with an (R)-(−)-carvone-based core
DOI: https://doi.org/10.1093/bbb/zbae091

続きを表示（残り 40 件）

[2024] Convergent Synthesis of Antitumor Aplysiatoxin Derivatives Based on a Combination of Ring‐Closing and Cross Metathesis
DOI: https://doi.org/10.1002/ejoc.202401074
[2024] Teleocidin B-4, a PKC Activator, Upregulates Hypoxia-Inducible Factor 1 (HIF-1) Activity by Promoting the Accumulation of HIF-1α Protein via the PKCα/mTORC Signaling Pathway
DOI: https://doi.org/10.1021/acs.jnatprod.4c00395
[2024] Integrated Spatial Multi-Omics Study of Postmortem Brains of Alzheimer’s Disease
DOI: https://doi.org/10.1267/ahc.24-00025
[2023] Synthesis of Stereoisomeric Simplified Analogs of Alotaketals toward the Elucidation of the Structural Requirements of Protein Kinase C Isozyme-Selective Binding
DOI: https://doi.org/10.1021/acs.orglett.2c04328
[2023] Chronic Treatment with Aβ42 with a Toxic Conformer and LPS Induces Inflammatory Responses in BV-2 Microglia with Dysregulation of Hypoxia-Inducible Factor Expression
DOI: https://doi.org/10.1248/bpb.b22-00855
[2023] Visualization of Amyloid Oligomers in the Brain of Patients with Alzheimer's Disease
[2023] Visualization of Amyloid Oligomers in the Brain of Patients with Alzheimer’s Disease
DOI: https://doi.org/10.1267/ahc.23-00058
[2023] Enhancement of Inhibitory Activity by Combining Allosteric Inhibitors Putatively Binding to Different Allosteric Sites on Cathepsin K
DOI: https://doi.org/10.3390/molecules28104197
[2023] Isolation and Purification of Harpagogenin as an Nrf2–ARE Activator from the Tubers of Chinese Artichoke (Stachys sieboldii)
DOI: https://doi.org/10.1248/bpb.b23-00383
[2023] Detection of Dietary Chalcone and Flavonoid Metabolites in Mice Using UPLC–MS/MS and Their Modulatory Effects on Amyloid β Aggregation
DOI: https://doi.org/10.1021/acs.jafc.3c02598
[2023] Biological evaluation of a phosphate ester prodrug of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, as a possible latency-reversing agent for HIV reactivation
DOI: https://doi.org/10.1093/bbb/zbad128
[2023] In vivo anti-cancer activity of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, and its possible signaling pathway associated with G1 arrest
DOI: https://doi.org/10.1016/j.bbrc.2023.07.008
[2023] Total Synthesis and Structure Revision of (+)-Lancilactone C
DOI: https://doi.org/10.1021/jacs.3c04124
[2023] Toward the Total Synthesis of Schinortriterpenoids: Construction of the All-cis-Substituted Cyclopropane Unit
DOI: https://doi.org/10.1055/a-2102-8014
[2022] Analysis of binding mode of vibsanin A with protein kinase C C1 domains: An experimental and molecular dynamics simulation study
DOI: https://doi.org/10.1016/j.molstruc.2022.132866
[2022] APP Knock-In Mice Produce E22P-Aβ Exhibiting an Alzheimer’s Disease-like Phenotype with Dysregulation of Hypoxia-Inducible Factor Expression
DOI: https://doi.org/10.3390/ijms232113259
[2022] Optimization of the Linker Length in the Dimer Model of E22P-Aβ40 Tethered at Position 38
DOI: https://doi.org/10.1021/acschemneuro.2c00436
[2022] A simplified analog of debromoaplysiatoxin lacking the B-ring of spiroketal moiety retains protein kinase C-binding and antiproliferative activities
DOI: https://doi.org/10.1016/j.bmc.2022.116988
[2022] Synthesis and Characterization of Propeller- and Parallel-Type Full-Length Amyloid β40 Trimer Models
DOI: https://doi.org/10.1021/acschemneuro.2c00363
[2022] Structural basis of the 24B3 antibody against the toxic conformer of amyloid β with a turn at positions 22 and 23
DOI: https://doi.org/10.1016/j.bbrc.2022.07.010
[2022] Design, synthesis, and biological activity of a synthetically accessible analog of aplysiatoxin with an (R)-(−)-carvone-based conformation-controlling unit
DOI: https://doi.org/10.1093/bbb/zbac084
[2022] Structure Optimization of the Toxic Conformation Model of Amyloid β42 by Intramolecular Disulfide Bond Formation
DOI: https://doi.org/10.1002/cbic.202200029
[2022] Activity-differential search for amyloid-β aggregation inhibitors using LC-MS combined with principal component analysis
DOI: https://doi.org/10.1016/j.bmcl.2022.128613
[2022] Synthetic Biology-Based Discovery of Diterpenoid Pyrones from the Genome of Eupenicillium shearii
DOI: https://doi.org/10.1021/acs.jnatprod.1c00973
[2022] AI and computational chemistry-accelerated development of an alotaketal analogue with conventional PKC selectivity
DOI: https://doi.org/10.1039/d2cc01759h
[2022] Lysine-targeting inhibition of amyloid β oligomerization by a green perilla-derived metastable chalcone in vitro and in vivo
DOI: https://doi.org/10.1039/d2cb00194b
[2021] Synthesis of Alkyl Bridged‐Tris‐α‐Amino Acids as C3‐Symmetric and Linear Linkers
DOI: https://doi.org/10.1002/ejoc.202001592
[2021] Frontispiz: Asymmetric Total Synthesis of Shagenes A and B
DOI: https://doi.org/10.1002/ange.202184361
[2021] The Novel PKC Activator 10-Methyl-Aplog-1 Combined with JQ1 Induced Strong and Synergistic HIV Reactivation with Tolerable Global T Cell Activation
DOI: https://doi.org/10.3390/v13102037
[2021] Searching for Natural Products That Delay Nucleation Phase and Promote Elongation Phase of Amyloid β42 toward Alzheimer’s Disease Therapeutics
DOI: https://doi.org/10.1021/acschemneuro.1c00489
[2021] Characterization of a Conformation-Restricted Amyloid β Peptide and Immunoreactivity of Its Antibody in Human AD brain
DOI: https://doi.org/10.1021/acschemneuro.1c00416
[2021] Asymmetric Total Synthesis of Shagenes A and B
DOI: https://doi.org/10.1002/anie.202109786
[2021] Asymmetric Total Synthesis of Shagenes A and B
DOI: https://doi.org/10.1002/ange.202109786
[2021] Development of a Novel Alzheimer's Disease Model Based on the Theory of the Toxic-conformer of Amyloid β
DOI: https://doi.org/10.1248/yakushi.20-00251-5
[2021] Two Types of PPARγ Ligands Identified in the Extract of Artemisia campestris
DOI: https://doi.org/10.3390/chemistry3020045
[2021] Effects of side chain length of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, on PKC binding, anti-proliferative, and pro-inflammatory activities
DOI: https://doi.org/10.1093/bbb/zbaa024
[2021] Studies Toward the Total Synthesis of Schinortriterpenoids: Diastereoselective Synthesis of the Left‐Hand Fragment
DOI: https://doi.org/10.1002/ejoc.202100510
[2021] アミロイドタンパク質を認識する核酸アプタマー
DOI: https://doi.org/10.1271/kagakutoseibutsu.59.216
[2021] Total synthesis and biological evaluation of oscillatoxins D, E, and F
DOI: https://doi.org/10.1093/bbb/zbab042
[2021] Toxic Amyloid-β42 Conformer May Accelerate the Onset of Alzheimer’s Disease in the Preclinical Stage
DOI: https://doi.org/10.3233/jad-201407

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（50 件）

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