Iwanari Kawamura 研究室

主宰者：Iwanari Kawamura

東京医科歯科大学

AI 要約（直近 5 年の研究成果）

Iwanari Kawamura研究室は、心臓の不整脈治療における新しい技術の開発と臨床応用に関する研究を行っています。特に、高周波通電やパルス状電場などのエネルギーを用いた心筋焼灼術（カテーテルアブレーション）に焦点を当て、異なるエネルギー形態の効果と安全性を検証する研究に取り組んでいます。心房細動を主な対象疾患として、従来の高周波焼灼法に加え、より新しいパルス電場焼灼法などの治療技術についても、動物モデルと臨床患者の両方で詳細に評価しています。研究では、実験的な検証と臨床データの両面から、焼灼の効率性と安全性の向上を目指しています。例えば、焼灼による病変形成の深さや大きさの最適化、電気刺激パターンが心電図パターンに与える影響の分析、異なる焼灼システムにおける合併症（溶血やカテーテル損傷など）の特性評価といった課題に取り組んでいます。また機械学習を用いた病変評価モデルの開発や、心拍数や呼吸に伴う信号変動の除去技術など、治療の精密性向上に関する工学的なアプローチも進めています。加えて、左心耳閉鎖術後の合併症管理や、植え込み型デバイスに関連した臨床課題への対応も研究範囲に含まれています。これらの研究を通じ、不整脈患者の治療成績向上と治療中の安全性確保に貢献することを目指しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

外部リンク

研究成果（100 件）

[2026] Accurate estimation of lesion metrics in radiofrequency ablation using machine learning model
DOI: https://doi.org/10.1093/ehjopen/oeag013
[2026] Extensive coronary venous system mapping for outflow tract ventricular arrhythmias: Utility of a dual over-the-wire microelectrode catheter technique
DOI: https://doi.org/10.1016/j.hrthm.2026.03.1951
[2026] Standardized Parallel Pace-Capture Testing as a Functional Endpoint for Lesion Validation
DOI: https://doi.org/10.1016/j.hrthm.2026.05.028
[2026] Paced QRS morphology and lead location in left bundle branch area pacing assessed by photon-counting cardiac computed tomography
DOI: https://doi.org/10.1016/j.hrthm.2026.03.1945
[2026] PO-04-147 COMPARISON OF ABLATION LESION CHARACTERISTICS BETWEEN SCARRED AND NORMAL MYOCARDIUM USING A TEMPERATURE-CONTROLLED HIGH-POWER ABLATION CATHETER
DOI: https://doi.org/10.1016/j.hrthm.2026.03.1166
[2026] Hemolysis After Pulsed Field Ablation With a Variable‐Loop Irrigated Circular Catheter
DOI: https://doi.org/10.1111/pace.70208
[2026] Distal Magnetic Sensors Eliminate Geometric Inaccuracy and Accelerate Mapping: A Preclinical Validation of a Novel Grid‐Style Catheter
DOI: https://doi.org/10.1111/jce.70284
[2026] Temporal Variability and Influence of Measurement Conditions of <scp>AI</scp> ‐Based Atrial Fibrillation Risk Estimation
DOI: https://doi.org/10.1002/joa3.70280
[2026] Very-high-power, ultra-short-duration radiofrequency for superior vena cava isolation: translational validation in porcine and clinical cohorts
DOI: https://doi.org/10.1093/europace/euag026
[2026] Safety Assessment of Pulsed Field Ablation Near the Sinus Node and His Bundle
DOI: https://doi.org/10.1161/circep.125.014823

続きを表示（残り 90 件）

[2026] Late dislodgement of a residual functional atrial lead 4 years after ventricular lead extraction: A case report
DOI: https://doi.org/10.1016/j.hrcr.2026.01.006
[2025] Evaluation of continuous arrhythmia monitoring using an implantable loop recorder in heart failure patients with a reduced ejection fraction: The LINQ2-HF trial rationale and protocol
DOI: https://doi.org/10.1371/journal.pone.0321604
[2025] Pulsed field ablation for pulmonary vein isolation provoked ganglionated plexus-mediated vagal atrial fibrillation
DOI: https://doi.org/10.1007/s10840-025-02106-8
[2025] PO-01-163 ACCESSORY PATHWAYS ASSOCIATED WITH LEFT ATRIAL DIVERTICULA
DOI: https://doi.org/10.1016/j.hrthm.2025.03.420
[2025] Transient accessory pathway conduction block caused by internal electrical cardioversion
DOI: https://doi.org/10.1016/j.jccase.2025.01.003
[2025] Left Atrial Appendage Occlusion in Patients With Atrial Fibrillation and Hemodialysis
DOI: https://doi.org/10.1016/j.jacep.2024.09.038
[2025] Managing Catheter Knotting in Pulse‐Select Pulsed Field Ablation: Mechanisms and a Practical Strategy for Resolution
DOI: https://doi.org/10.1002/joa3.70250
[2025] Left Bundle Branch Area Pacing Corrected the Functional Block Line Caused by Right Ventricular Apex Pacing
DOI: https://doi.org/10.1111/pace.15195
[2025] A Case of Recurrent Transient Upper Airway Disturbance During Pulsed Field Ablation
DOI: https://doi.org/10.1111/jce.16675
[2025] PO-FP-010 DISCRIMINATING VIABLE TISSUE FROM TRUE SCAR USING PEAK FREQUENCY AND OMNIPOLAR VOLTAGE
DOI: https://doi.org/10.1016/j.hrthm.2025.03.177
[2025] PO-04-061 RELATION BETWEEN OMNIPOLAR VOLTAGE, PEAK FREQUENCY, AND THE DISTANCE FROM THE ENDOCARDIAL SURFACE
DOI: https://doi.org/10.1016/j.hrthm.2025.03.1195
[2025] PO-04-087 SAFETY ASSESSMENT OF PULSED FIELD ABLATION NEAR THE SINUS NODE
DOI: https://doi.org/10.1016/j.hrthm.2025.03.1221
[2025] PO-04-094 EFFECT OF PULSED FIELD ABLATION WITH A VARIABLE LOOP CATHETER ON CARDIAC DEVICE SYSTEM
DOI: https://doi.org/10.1016/j.hrthm.2025.03.1228
[2025] PO-04-051 RELATION BETWEEN OMNIPOLAR VOLTAGE AND ANATOMICAL WALL THICKNESS
DOI: https://doi.org/10.1016/j.hrthm.2025.03.1185
[2025] PO-06-090 THE INCIDENCE OF FAILURE OF REMAINING FUNCTIONAL LEADS AND NEWLY IMPLANTED LEADS AFTER TRANSVENOUS LEAD EXTRACTION
DOI: https://doi.org/10.1016/j.hrthm.2025.03.1637
[2025] PO-04-055 IMPACT OF CATHETER TYPE AND TISSUE INTERFACE ANGLE ON VOLTAGE, PEAK FREQUENCY, AND PACING THRESHOLDS
DOI: https://doi.org/10.1016/j.hrthm.2025.03.1189
[2025] PO-03-206 AN OPTIMAL OUTPUT AND ELECTRODE CONFIGURATION FOR EVALUATING TISSUE TRANSMURALITY – A PRECLINICAL STUDY
DOI: https://doi.org/10.1016/j.hrthm.2025.03.1116
[2025] Incidence of cough reflex and vagal response among various pulsed field ablation systems: a multicenter registry study
DOI: https://doi.org/10.1007/s00392-025-02806-1
[2025] Impact of 1 mm difference in interelectrode spacing on local electrograms and voltage/activation maps
DOI: https://doi.org/10.1093/europace/euaf135
[2025] Comparison of hemolysis with different pulsed field ablation systems
DOI: https://doi.org/10.1016/j.hrthm.2025.05.072
[2025] Averaging real-time impedance enhances the prediction of steam pop risk and lesion characteristics
DOI: https://doi.org/10.1093/europace/euaf315
[2025] Assessment of far-field capture in a box-scar lesion: a two-dimensional analysis
DOI: https://doi.org/10.1093/eurheartj/ehaf784.824
[2025] Impact of activation direction on omnipolar voltage and peak frequency
DOI: https://doi.org/10.1093/eurheartj/ehaf784.473
[2025] Lesion Depth Optimization in High‐Power Radiofrequency Ablation: Evaluating Single High‐Power and Combined Very High‐Power Applications
DOI: https://doi.org/10.1111/jce.70125
[2025] Outcomes of Scar-Related Ventricular Tachycardia Ablation With Percutaneous Left Ventricular Assist Device Support
DOI: https://doi.org/10.1016/j.jacep.2025.07.016
[2025] Comparison of far-field and peak frequency electrogram characteristics at the earliest activation sites during idiopathic ventricular arrhythmias: A novel index to predict ablation success
DOI: https://doi.org/10.1016/j.hrthm.2025.09.015
[2024] Characteristics and incidence of peri-device leaks after left atrial appendage closure in patients with prior electrical isolation of left atrial appendage during catheter ablation
DOI: https://doi.org/10.1093/europace/euae102.246
[2024] Endocardial Pulsed Field Ablation and the Oesophagus: Are Atrio-oesophageal Fistulas Now History?
DOI: https://doi.org/10.15420/aer.2023.16
[2024] Effect of reference electrode on intracardiac electrograms: Close indifferent electrode vs Wilson central terminal
DOI: https://doi.org/10.1016/j.hrthm.2024.03.002
[2024] PO-03-055 ISCHEMIC STROKE SEVERITY AND MORTALITY AFTER LEFT ATRIAL APPENDAGE CLOSURE VS NONWARFARIN ORAL ANTICOAGULANTS IN PATIENTS WITH PRIOR STROKE
DOI: https://doi.org/10.1016/j.hrthm.2024.03.1056
[2024] PO-05-139 THE OPTIMAL STRATEGY FOR PULMONARY VEIN ANTRAL ISOLATION USING VERY HIGH-POWER SHORT-DURATION RADIOFREQUENCY
DOI: https://doi.org/10.1016/j.hrthm.2024.03.1374
[2024] PO-06-047 LONG-TERM OUTCOMES OF CARDIONEUROABLATION FOR VASOVAGAL SYNCOPE: THE BEAT-SYNCOPE STUDY AND META-ANALYSIS
DOI: https://doi.org/10.1016/j.hrthm.2024.03.1673
[2024] Pulsed Field Mapping of Ventricular Tachycardia
DOI: https://doi.org/10.1016/j.jacep.2023.12.005
[2024] Efficacy and Safety of High‐Power Short‐Duration Ablation for Cavo‐Tricuspid Isthmus With a Flexible‐Tip Temperature‐Controlled Power Regulation Catheter Performed by Electrophysiology Trainees
DOI: https://doi.org/10.1111/jce.16516
[2024] Significance of the local largest bipolar voltage for the optimized ablation strategy using very high‐power short duration mode
DOI: https://doi.org/10.1111/jce.16453
[2024] Embryological Classification of Arrhythmogenic Triggers Initiating Atrial Fibrillation
DOI: https://doi.org/10.1016/j.jacc.2024.08.060
[2024] Feasibility and safety assessment of RF double applications in very high power and short duration ablation
DOI: https://doi.org/10.1016/j.hrthm.2024.10.026
[2024] Risk of right coronary artery injury and distance from tricuspid valve ring to right coronary artery in radiofrequency ablation
DOI: https://doi.org/10.1093/eurheartj/ehae666.400
[2024] Distribution of antral lesions with the novel size‐adjustable cryoballoon for pulmonary vein isolation and the differences based on left atrial remodeling
DOI: https://doi.org/10.1111/jce.16415
[2024] The impact of hyperbaric oxygen treatment for cardiovascular implantable electronic devices
DOI: https://doi.org/10.1002/joa3.13070
[2024] Ablating Myocardium Using Nanosecond Pulsed Electric Fields: Preclinical Assessment of Feasibility, Safety, and Durability
DOI: https://doi.org/10.1161/circep.124.012854
[2024] Preclinical Study of Pulsed Field Ablation of Difficult Ventricular Targets: Intracavitary Mobile Structures, Interventricular Septum, and Left Ventricular Free Wall
DOI: https://doi.org/10.1161/circep.124.012734
[2024] Ischemic stroke severity and mortality after left atrial appendage closure vs nonwarfarin oral anticoagulants in patients with prior stroke
DOI: https://doi.org/10.1016/j.hrthm.2024.05.030
[2024] PO-06-136 ACHIEVING TRANSMURAL ABLATION OF THE LEFT VENTRICLE: A PRECLINICAL ASSESSMENT OF BIPOLAR PULSED FIELD ABLATION
DOI: https://doi.org/10.1016/j.hrthm.2024.03.1579
[2024] PO-02-106 CORONARY ARTERIAL EFFECTS OF PULSED FIELD ABLATION VS RADIOFREQUENCY ABLATION: PRECLINICAL INSIGHTS
DOI: https://doi.org/10.1016/j.hrthm.2024.03.721
[2024] PO-06-197 VENTRICULAR TACHYCARDIA ABLATION IN A PATIENT WITH LEFT VENTRICULAR PSEUDOANEURYSM USING PULSED FIELD ABLATION
DOI: https://doi.org/10.1016/j.hrthm.2024.03.1743
[2024] PO-06-150 A PRECLINICAL EVALUATION OF PULSED ELECTRICAL FIELDS TO ABLATE A MOBILE INTRACAVITARY STRUCTURE – PAPILLARY MUSCLES
DOI: https://doi.org/10.1016/j.hrthm.2024.03.1593
[2024] PO-06-148 FIELDBENDING: A NOVEL BIPOLAR PULSED FIELD ELECTRODE CONFIGURATION TO IMPROVE TOLERABILITY
DOI: https://doi.org/10.1016/j.hrthm.2024.03.1591
[2024] PO-06-135 PRECLINICAL ASSESSMENT OF A FORM-FITTING MAPPING AND PULSED FIELD ABLATION CATHETER
DOI: https://doi.org/10.1016/j.hrthm.2024.03.1578
[2024] MP-483493-004 SUPERIORITY OF LONG-DURATION RADIOFREQUENCY ABLATION TO THE USE OF HALF-NORMAL SALINE IRRIGATION IN INCREASING LESION SIZE
DOI: https://doi.org/10.1016/j.hrthm.2024.03.416
[2024] PO-01-128 IS RIGHT ATRIAL APPENDAGE EXIT FOR EPICARDIAL ACCESS FEASIBLE AFTER THERAPEUTIC ANTICOAGULATION? A PRECLINICAL EVALUATION
DOI: https://doi.org/10.1016/j.hrthm.2024.03.539
[2024] Management of peri-device leaks after left atrial appendage closure using endovascular coils and/or amplatzer plugs and radiofrequency ablation
DOI: https://doi.org/10.1093/europace/euae102.247
[2024] An optimized approach for increasing lesion size in temperature‐controled setting using a catheter with a surface thermocouple and efficient irrigation
DOI: https://doi.org/10.1002/joa3.13040
[2024] A randomized controlled trial of the size-adjustable cryoballoon vs conventional cryoballoon for paroxysmal atrial fibrillation: The CONTRAST-CRYO II trial rationale and design
DOI: https://doi.org/10.1016/j.hroo.2024.04.006
[2024] Impact of contact force on the lesion characteristics of very high‐power short‐duration ablation using a <scp>QDOT‐MICRO</scp> catheter
DOI: https://doi.org/10.1002/joa3.12992
[2023] PO-03-189 THROMBOEMBOLISM BEFORE VS AFTER PERCUTANEOUS CLOSURE OF PERI-DEVICE LEAKS RESULTING FROM PERCUTANEOUS LEFT ATRIAL APPENDAGE OCCLUSION
DOI: https://doi.org/10.1016/j.hrthm.2023.03.890
[2023] PO-01-105 PRECLINICAL EVALUATION OF ACUTE AND CHRONIC CIRCUMFERENTIAL, LINEAR AND FOCAL PULSED FIELD ABLATION LESION SETS CREATED USING A “MAP & ABLATE” SPHERICAL MULTIELECTRODE ARRAY CATHETER
DOI: https://doi.org/10.1016/j.hrthm.2023.03.677
[2023] PO-01-005 GANGLIONATED PLEXI MEDIATED BRADYCARDIA RESPONSES: A PRE-CLINICAL STUDY OF DIFFERENCES BETWEEN PULSED FIELD AND RADIOFREQUENCY ABLATION IN THE LEFT ATRIUM
DOI: https://doi.org/10.1016/j.hrthm.2023.03.634
[2023] MP-453091-3 SGLT2 INHIBITORS REDUCE RISK OF SUDDEN CARDIAC DEATH IN PATIENTS WITH HEART FAILURE: A META-ANALYSIS OF RANDOMIZED CLINICAL TRIALS
DOI: https://doi.org/10.1016/j.hrthm.2023.03.425
[2023] Preclinical assessment of the feasibility, safety and lesion durability of a novel ‘single-shot’ pulsed field ablation catheter for pulmonary vein isolation
DOI: https://doi.org/10.1093/europace/euad030
[2023] PV Isolation Using a Spherical Array PFA Catheter
DOI: https://doi.org/10.1016/j.jacep.2023.01.022
[2023] Electrophysiology, Pathology, and Imaging of Pulsed Field Ablation of Scarred and Healthy Ventricles in Swine
DOI: https://doi.org/10.1161/circep.122.011369
[2023] PO-04-073 ELECTRON MICROSCOPIC INSIGHTS FROM AN ACUTE PULSED FIELD MYOCARDIAL LESION
DOI: https://doi.org/10.1016/j.hrthm.2023.03.1118
[2023] Ultrastructural insights from myocardial ablation lesions from microsecond pulsed field vs radiofrequency energy
DOI: https://doi.org/10.1016/j.hrthm.2023.12.017
[2023] Transcoronary mapping with an over-the-wire multielectrode catheter in scar-related ventricular tachycardia patients
DOI: https://doi.org/10.1093/europace/euad365
[2023] Severity of Ischemic Stroke After Left Atrial Appendage Closure vs Nonwarfarin Oral Anticoagulants
DOI: https://doi.org/10.1016/j.jacep.2023.10.012
[2023] The effect of half-normal saline irrigation on lesion characteristics in temperature-flow-controlled ablation
DOI: https://doi.org/10.1007/s10840-023-01678-7
[2023] Abstract 12536: Occurrence of New-Onset Atrial Fibrillation in Patients After Left Atrial Appendage Closure
DOI: https://doi.org/10.1161/circ.148.suppl_1.12536
[2023] Peri-device leak after left atrial appendage closure: echocardiographic characteristics and thromboembolism risk
DOI: https://doi.org/10.1093/eurheartj/ehad655.555
[2023] Superiority of the Combination of Input and Output Parameters to the Single Parameter for Lesion Size Estimation
DOI: https://doi.org/10.1253/circj.cj-23-0574
[2023] Reversible Pulsed Electrical Fields as an In Vivo Tool to Study Cardiac Electrophysiology: The Advent of Pulsed Field Mapping
DOI: https://doi.org/10.1161/circep.123.012018
[2023] ECG characteristics of “true” left bundle branch block: Insights from transcatheter aortic valve–related LBBB and His-Purkinje conduction system pacing–correctable LBBB
DOI: https://doi.org/10.1016/j.hrthm.2023.09.004
[2023] A Novel ECG-Based Deep Learning Algorithm to Predict Cardiomyopathy in Patients With Premature Ventricular Complexes
DOI: https://doi.org/10.1016/j.jacep.2023.05.025
[2023] Interatrial Block Association With Adverse Cardiovascular Outcomes in Patients Without a History of Atrial Fibrillation
DOI: https://doi.org/10.1016/j.jacep.2023.04.006
[2023] Worldwide Experience With an Irrigated Needle Catheter for Ablation of Refractory Ventricular Arrhythmias
DOI: https://doi.org/10.1016/j.jacep.2023.05.014
[2023] LB-456089-3 WORLD WIDE EXPERIENCE WITH AN END-HOLE IRRIGATED NEEDLE CATHETER FOR ABLATION OF REFRACTORY VENTRICULAR ARRHYTHMIAS: FINAL REPORT
DOI: https://doi.org/10.1016/j.hrthm.2023.04.031
[2023] PO-03-162 INCIDENCE AND PREDICTORS OF PERI-DEVICE LEAKS IN A REAL-WORLD SETTING AFTER LEFT ATRIAL APPENDAGE CLOSURE WITH WATCHMAN DEVICE
DOI: https://doi.org/10.1016/j.hrthm.2023.03.882
[2023] PO-04-067 NANOSECOND PULSED FIELD ABLATION: DEMONSTRATION OF HALO-SHAPED LESIONS WITH A NOVEL MULTIELECTRODE SYSTEM: INITIAL PRECLINICAL EXPERIENCE
DOI: https://doi.org/10.1016/j.hrthm.2023.03.1112
[2023] PO-04-096 CREATING DEEP VENTRICULAR LESIONS WITH NANOSECOND PULSED FIELD ABLATION: PATHOLOGICAL AND IMAGING INSIGHTS FROM PRECLINICAL EVALUATION
DOI: https://doi.org/10.1016/j.hrthm.2023.03.1123
[2023] PO-04-154 A NOVEL 12-LEAD ECG-BASED DEEP LEARNING ALGORITHM TO PREDICT CARDIOMYOPATHY IN PATIENTS WITH PVCS
DOI: https://doi.org/10.1016/j.hrthm.2023.03.1283
[2023] PO-04-172 OUTCOMES OF SCAR-RELATED VENTRICULAR TACHYCARDIA ABLATION WITH PERCUTANEOUS LEFT VENTRICULAR ASSIST DEVICE SUPPORT: A PROPENSITY SCORE-MATCHED ANALYSIS
DOI: https://doi.org/10.1016/j.hrthm.2023.03.1199
[2023] PO-04-063 EFFECT OF PULSED FIELD ABLATION ON THE BRONCHUS: PRECLINICAL INSIGHTS
DOI: https://doi.org/10.1016/j.hrthm.2023.03.1108
[2023] PO-455617-21 SGLT2 INHIBITORS REDUCE RISK OF SUDDEN CARDIAC DEATH IN PATIENTS WITH HEART FAILURE: A META-ANALYSIS OF RANDOMIZED CLINICAL TRIALS
DOI: https://doi.org/10.1016/j.hrthm.2023.03.1521
[2023] PO-05-034 CLINICAL CHARACTERISTICS AND OUTCOMES AFTER VENTRICULAR TACHYCARDIA ABLATION USING ULTRALOW TEMPERATURE CRYOABLATION IN PATIENTS WITH PRIOR CATHETER ABLATION
DOI: https://doi.org/10.1016/j.hrthm.2023.03.1320
[2023] CE-452771-2 MANAGING PERI-DEVICE LEAKS AFTER LEFT ATRIAL APPENDAGE CLOSURE USING ENDOVASCULAR COILS AND/OR PLUGS
DOI: https://doi.org/10.1016/j.hrthm.2023.03.270
[2022] PO-713-05 ISCHEMIC STROKE AFTER PROPHYLAXIS WITH LEFT ATRIAL APPENDAGE CLOSURE VS NON-WARFARIN ORAL ANTICOAGULANTS: A “REAL-WORLD” MULTICENTER COMPARISON OF STROKE SEVERITY
DOI: https://doi.org/10.1016/j.hrthm.2022.03.1146
[2022] Thirty-day readmission rate of same-day discharge protocol after left atrial appendage occlusion: A propensity score–matched analysis from the National Readmission Database
DOI: https://doi.org/10.1016/j.hrthm.2022.07.006
[2022] Pulsed Field Ablation of the Porcine Ventricle Using a Focal Lattice-Tip Catheter
DOI: https://doi.org/10.1161/circep.122.011120
[2022] Preclinical evaluation of semi‐automated laser ablation for pulmonary vein isolation: A comparative study
DOI: https://doi.org/10.1111/jce.15777
[2022] Selective sparing of Purkinje fibres with pulsed-field myocardial ablation
DOI: https://doi.org/10.1093/europace/euac179

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AI 要約（直近 5 年の研究成果）

外部リンク

関連研究室(8 件)

研究成果（100 件）

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所属学会・役職（0 件）