Genzoh Tanabe 研究室

主宰者：Genzoh Tanabe

近畿大学

AI 要約（直近 5 年の研究成果）

田辺研究室は、複雑な有機化合物の合成と生物機能の解明に取り組んでいます。研究の主軸は、天然由来の低分子化合物と酵素タンパク質の相互作用を対象としており、特に炭水化物代謝に関わる酵素の阻害剤や、細菌が産生する二次代謝産物の構造解析に注力しています。食後血糖値の上昇を抑制する医薬品開発を目指した α-グルコシダーゼ阻害剤の設計・合成では、硫黄やセレン原子を含むユニークな化学構造を導入し、既存薬よりも優れた活性と安定性を実現しています。同時に、細菌が非リボソーム性ペプチド合成酵素というタンパク質を用いて産生する抗生物質や毒性因子に注目し、これらの合成経路を阻害する低分子化合物の開発を進めています。化学探針（プローブ分子）を設計して、生きた細胞内でこれらの酵素の活動を捕捉・可視化する技術も構築しており、複雑な生物現象の仕組みを化学的視点から理解することを目指しています。さらに、細菌の蛋白質分解システムに関わるプロテアーゼの機構解析を行い、感染症治療への応用を検討しています。このように、合成化学と生化学を統合したアプローチにより、医学・薬学への応用可能性を有する基礎研究を展開しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（46 件）

[2026] Investigation of the Linker‐Length Preferences of Pantetheine Probes in the Cross‐Linking Reactions Between Adenylation Enzymes and Carrier Proteins
DOI: https://doi.org/10.1002/cbic.70359
[2026] Design, synthesis of novel methyl-glycosyl furanose based sulfonium type α-glucosidase inhibitors with potent antihyperglycemic activity
DOI: https://doi.org/10.1016/j.ejmech.2026.118757
[2026] Discovery of Novel C-glycosyl Pyranose-Based Sulfonium and Selenonium Salts Targeting α-Glucosidase with Potent Antihyperglycemic Activity
DOI: https://doi.org/10.1021/acs.jmedchem.5c02873
[2026] Structure–activity relationship for calanthoside, a potential hair-growth stimulant with an indole 2- S -,3- O -bis-glucoside structure. Part 1: role of two glucoside moieties in promoting HFDPC proliferation
DOI: https://doi.org/10.1039/d6md00273k
[2026] Total Synthesis of Kayeassamin A and Mammeasin A: Overcoming Challenges in the Construction of Sterically Overcrowded Pentasubstituted Coumarin Frameworks
DOI: https://doi.org/10.1021/acs.joc.6c00148
[2025] Design and Synthesis of Sulfonium and Selenonium Derivatives Bearing 3′,5′‐ O ‐Benzylidene Acetal Side Chains as Potent α ‐Glucosidase Inhibitors
DOI: https://doi.org/10.1002/cmdc.202500299
[2025] Design and Synthesis of Sulfonium and Selenonium Derivatives Bearing 3′,5′-O-Benzylidene Acetal Side Chain Structure as Potent α-Glucosidase Inhibitors
DOI: https://doi.org/10.3390/molecules30132856
[2025] Exploring the Substrate Flexibility of GrsB Thioesterase Leads to the Structural Reassignment of a Gramicidin S Variant
DOI: https://doi.org/10.1002/cbic.202500412
[2025] Calcium/Calmodulin‐Dependent Protein Kinase II Inhibitors Mitigate High‐Fat Diet–Induced Obesity in Mice
DOI: https://doi.org/10.1155/jobe/5530467
[2025] Synthesis and biological evaluation of γ-alkylidenebutenolides isolated from Melodorum fruticosum : the role of the propylidene-type side chain structure on anti-melanogenic activity
DOI: https://doi.org/10.1039/d5ob00449g

続きを表示（残り 36 件）

[2025] Synthesis of trans‐Fused 3,6‐Anhydro Hexofuranose Frameworks via Catalytic Hydrogenolysis Triggered Debenzylative Intramolecular Acetalation
DOI: https://doi.org/10.1002/cmdc.202400907
[2025] Dynamic Oligomerization Processes of Bacillus subtilis ClpP Protease Induced by ADEP1 Studied with High-Speed Atomic Force Microscopy
DOI: https://doi.org/10.1021/acsomega.4c11303
[2025] Degradation of Nonribosomal Peptide Synthetase Megasynthetases SrfAA and SrfAB by Acyldepsipeptide‐Activated ClpP in Bacillus Subtilis
DOI: https://doi.org/10.1002/cbic.202500135
[2025] Inhibition of Surfactin Biosynthesis in Bacillus Subtilis Using Cell‐Permeable Adenylation Domain Inhibitors
DOI: https://doi.org/10.1002/cbic.202500136
[2025] Synthesis of Neokotalanol and Its Derivatives as Potent α-Glucosidase Inhibitors
DOI: https://doi.org/10.1021/acs.orglett.5c03549
[2024] Protein degradation in bacteria: focus on the ClpP protease
DOI: https://doi.org/10.3412/jsb.79.1
[2024] Development of a chemical scaffold for inhibiting nonribosomal peptide synthetases in live bacterial cells
DOI: https://doi.org/10.3762/bjoc.20.39
[2024] Role of the thiosugar ring in the inhibitory activity of salacinol, a potent natural α-glucosidase inhibitor
DOI: https://doi.org/10.1039/d3ra08485j
[2024] Proteolytic Regulation in the Biosynthesis of Natural Product Via a ClpP Protease System
DOI: https://doi.org/10.1021/acschembio.4c00304
[2024] Probing for optimal photoaffinity linkers of benzophenone-based photoaffinity probes for adenylating enzymes
DOI: https://doi.org/10.1016/j.bmc.2024.117815
[2024] ACA-28, an ERK MAPK Signaling Modulator, Exerts Anticancer Activity through ROS Induction in Melanoma and Pancreatic Cancer Cells
DOI: https://doi.org/10.1155/2024/7683793
[2024] Radical Nitrososulfonation of Propargyl Alcohols: Thiazolidine-2,4-dione-Assisted Synthesis of 5-Alykyl-4-sulfonylisoxazoles
DOI: https://doi.org/10.1021/acs.orglett.3c03674
[2024] Biosynthetic Incorporation of Non-native Aryl Acid Building Blocks into Peptide Products Using Engineered Adenylation Domains
DOI: https://doi.org/10.1021/acschembio.4c00663
[2023] Design and Synthesis of Sulfonium Derivatives: A Novel Class of α-Glucosidase Inhibitors with Potent In Vivo Antihyperglycemic Activities
DOI: https://doi.org/10.1021/acs.jmedchem.2c01984
[2023] Exploring a chemical scaffold for rapid and selective photoaffinity labelling of non-ribosomal peptide synthetases in living bacterial cells
DOI: https://doi.org/10.1098/rstb.2022.0026
[2023] Biosynthetic diversification of non-ribosomal peptides through activity-based protein profiling of adenylation domains
DOI: https://doi.org/10.1039/d3cc02633g
[2023] Chemoproteomic Profiling of Adenylation Domain Functions in Gramicidin S-Producing Non-ribosomal Peptide Synthetases
DOI: https://doi.org/10.1007/978-1-0716-3214-7_4
[2023] Chemical Labeling of Protein 4′-Phosphopantetheinylation in Surfactin-Producing Nonribosomal Peptide Synthetases
DOI: https://doi.org/10.1007/978-1-0716-3214-7_15
[2023] Total Synthesis of Calanthoside, a Potential Hair Growth Stimulant: A Facile Synthetic Approach via One-Pot S- and O-Glucosidic Bond Formation
DOI: https://doi.org/10.1021/acs.jnatprod.3c00815
[2023] Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin (IV) prodrug delivery and enhanced colorectal cancer therapy
DOI: https://doi.org/10.1016/j.cclet.2023.108656
[2023] <scp>ACAGT</scp>‐007a, an anti‐cancer compound that modulates <scp>ERK MAPK</scp> signaling, induces nuclear enrichment of phosphorylated <scp>ERK</scp> in <scp>T3M4</scp> pancreatic cancer cells
DOI: https://doi.org/10.1111/gtc.13026
[2022] Structure-activity relationship study of 4,5-didehydroguadiscine, an aporphine alkaloid showing potent melanogenesis-inhibitory activity in B16 melanoma cells
DOI: https://doi.org/10.1016/j.bmcl.2022.129034
[2022] Divergent Synthesis of Decahydroquinoline‐Type Poison‐Frog Alkaloids
DOI: https://doi.org/10.1002/slct.202104533
[2022] Synthetic studies on naturally occurring sulfonium-type α-glucosidase inhibitors: progress and perspective
DOI: https://doi.org/10.1080/07328303.2022.2115508
[2022] Activity-based protein profiling of a surfactin-producing nonribosomal peptide synthetase in Bacillus subtilis
DOI: https://doi.org/10.1016/j.xpro.2022.101462
[2022] Developing crosslinkers specific for epimerization domain in NRPS initiation modules to evaluate mechanism
DOI: https://doi.org/10.1039/d2cb00005a
[2022] A hydrolysate of poly-trans-[(2-carboxyethyl)germasesquioxane] (Ge-132) suppresses Cav3.2-dependent pain by sequestering exogenous and endogenous sulfide
DOI: https://doi.org/10.1016/j.redox.2022.102579
[2022] ACAGT-007a, an ERK MAPK Signaling Modulator, in Combination with AKT Signaling Inhibition Induces Apoptosis in KRAS Mutant Pancreatic Cancer T3M4 and MIA-Pa-Ca-2 Cells
DOI: https://doi.org/10.3390/cells11040702
[2021] Chemoproteomics profiling of surfactin-producing nonribosomal peptide synthetases in living bacterial cells
DOI: https://doi.org/10.1016/j.chembiol.2021.05.014
[2021] Ligand compatibility of salacinol-type α-glucosidase inhibitors toward the GH31 family
DOI: https://doi.org/10.1039/d0ra10038b
[2021] Mutational Biosynthesis of Hitachimycin Analogs Controlled by the β-Amino Acid–Selective Adenylation Enzyme HitB
DOI: https://doi.org/10.1021/acschembio.1c00003
[2021] Synthesis of Azepino[1,2‐a]indole‐10‐amines via [6+1] Annulation of Ynenitriles with Reformatsky Reagent
DOI: https://doi.org/10.1002/ejoc.202100021
[2021] Divergent synthesis of γ-alkylidene butenolides from Thai medicinal plant Melodorum fruticosum and evaluation of those inhibitory effects on melanogenesis
[2021] Activity, Binding, and Modeling Studies of a Reprogrammed Aryl Acid Adenylation Domain with an Enlarged Substrate Binding Pocket
DOI: https://doi.org/10.1248/cpb.c20-00704
[2021] Inhibition of efflux pumps aids small-molecule probe-based fluorescence labeling and imaging in the Gram-negative bacterium Escherichia coli
DOI: https://doi.org/10.1039/d1ob01112j
[2021] Microwave‐Assisted Synthesis of d/l‐Agrimonolide
DOI: https://doi.org/10.1002/ajoc.202100334

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（46 件）

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