Nobuhiko Ohno 研究室

主宰者：Nobuhiko Ohno

自治医科大学

AI 要約（直近 5 年の研究成果）

大野伸彦研究室は、脳や神経組織における細胞間の相互作用と構造変化に焦点を当てた研究を展開しています。特に、ニューロンとグリア細胞（オリゴデンドロサイト、神経幹細胞など）の相互作用、および神経突起の成長と移動のメカニズムを解明することを目指しています。研究対象となる現象は、脳損傷後の神経再生、加齢に伴う認知機能低下、髄鞘形成障害、および神経変性疾患に関連する異常など多岐にわたります。研究室の特徴は、微細構造の詳細な観察にあります。走査型電子顕微鏡による三次元的な再構成、電気生理学的記録、トランスジェニックマウスモデルを組み合わせることで、細胞レベルでの形態変化と機能変化の関係を明らかにしています。例えば、シナプス構造と記憶保持の関係、ミトコンドリアの障害が認知機能に及ぼす影響、および細胞間の接着分子が神経移動を制御する仕組みなどを検証しています。得られた知見は、脳損傷や神経変性疾患の治療戦略の開発につながる可能性があります。神経細胞の移動促進、髄鞘形成の改善、そして内在的な神経再生能の活性化に関する基礎的な理解が蓄積されつつあり、これらは将来的な医療応用を視野に入れた研究として位置づけられています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（87 件）

[2026] Bone mineral loss damages renal tubules in mice
DOI: https://doi.org/10.1038/s42003-026-09603-0
[2026] Synaptic mitochondrial oxidative stress drives individual variability in age-related cognitive decline in mice
DOI: https://doi.org/10.64898/2026.01.08.698304
[2026] Role of Upregulated Mucin 21 in Detached Lung Cancer Cells
DOI: https://doi.org/10.1111/pin.70141
[2026] Presynaptic SNAP25 supports maturation of hippocampal mossy fiber-CA3 synapses
DOI: https://doi.org/10.1016/j.isci.2026.116503
[2026] Distinct pathophysiological mechanisms of CEP152 variants in microcephaly and brain abnormalities
DOI: https://doi.org/10.1038/s44321-026-00427-3
[2026] Toward the promotion of One Health – Part II: Interdisciplinary research cooperation between digital transformation and exposome
DOI: https://doi.org/10.1016/j.jphyss.2026.100078
[2026] Cytoarchitecture of neurogenic niche and neuroblast clusters in the postnatal microminipig brain
DOI: https://doi.org/10.1016/j.stemcr.2026.102893
[2026] WCN26-5907 Morphological alterations of primary cilia in renal tubules of a rat model of polycystic kidney disease
DOI: https://doi.org/10.1016/j.ekir.2026.104486
[2026] WCN26-7292 National Survey Report on Podocyte Infolding Glomerulopathy in Japan: Proposal for a Morphological Classification Based on Electron Microscopy
DOI: https://doi.org/10.1016/j.ekir.2026.106289
[2026] Altered ciliary morphology reduces mechanosensation in a cystic kidney model as indicated by a mathematical model
DOI: https://doi.org/10.1038/s41598-026-39179-y

続きを表示（残り 77 件）

[2026] Neuronal TDP-43 regulates myelin formation via neurexin 1 mRNA stabilization
DOI: https://doi.org/10.1073/pnas.2513642123
[2025] Channel synapse mediates neurotransmission of airway protective chemoreflexes
DOI: https://doi.org/10.1016/j.cell.2025.03.007
[2025] Brain State-Dependent Neocortico-Hippocampal Network Dynamics Are Modulated by Postnatal Stimuli
DOI: https://doi.org/10.1523/jneurosci.0053-21.2025
[2025] Artificial hibernation uncovers distinct synaptic engram architecture for memory retention
DOI: https://doi.org/10.64898/2025.12.09.692927
[2025] The combination of venetoclax with dimethyl fumarate synergistically induces apoptosis in AML cells by disrupting mitochondrial integrity through ROS accumulation
DOI: https://doi.org/10.1038/s41419-025-08040-x
[2025] Phagophores originate from endoplasmic reticulum membranes in vasopressin neurons in a mouse model of familial neurohypophysial diabetes insipidus
DOI: https://doi.org/10.1007/s00441-025-04013-w
[2025] Reduced Accumulation Rate and Morphological Changes of Newly Generated Myelinating Oligodendrocytes in the Corpus Callosum of Aged Mice
DOI: https://doi.org/10.1002/glia.70070
[2025] Effects of Hypertension Induced by 0.3% Saline Loading on Diabetic Retinopathy in Spontaneously Diabetic Torii Fatty Rats
DOI: https://doi.org/10.3390/diabetology6080073
[2025] Transformation of radial glia into postnatal neural stem cells depends on birth
DOI: https://doi.org/10.1016/j.celrep.2025.116029
[2025] Mipep deficiency in adipocytes impairs mitochondrial protein maturation and leads to systemic inflammation and metabolic dysfunctions
DOI: https://doi.org/10.1038/s41598-025-97307-6
[2025] Type I collagen secreted in white matter lesions inhibits remyelination and functional recovery
DOI: https://doi.org/10.1038/s41419-025-07633-w
[2025] Three-dimensional ultrastructural analysis of human skin with the arrector pili muscle interacting with the hair follicle epithelium
DOI: https://doi.org/10.1038/s41598-025-88615-y
[2024] Apomorphine is a potent inhibitor of ferroptosis independent of dopaminergic receptors
DOI: https://doi.org/10.1038/s41598-024-55293-1
[2024] Identification of the growth cone as a probe and driver of neuronal migration in the injured brain
DOI: https://doi.org/10.1038/s41467-024-45825-8
[2024] Axonal Selectivity of Myelination by Single Oligodendrocytes Established During Development in Mouse Cerebellar White Matter
DOI: https://doi.org/10.1002/glia.24660
[2024] In-depth morphological and functional analysis of ATTR-CA myocardial cells and niche by electron microscopic 3D reconstruction
DOI: https://doi.org/10.1093/eurheartj/ehae666.2078
[2024] Mitochondrial Ultrastructure and Its Regulation Revealed by Deep Learning-based Analysis
DOI: https://doi.org/10.1093/mam/ozae044.484
[2024] Regional differences in the ultrastructure of mucosal macrophages in the rat large intestine
DOI: https://doi.org/10.1007/s00441-024-03883-w
[2024] 5′ Transgenes drive leaky expression of 3′ transgenes in Cre-inducible bi-cistronic vectors
DOI: https://doi.org/10.1016/j.omtm.2024.101288
[2024] Neuraminidase inhibition promotes the collective migration of neurons and recovery of brain function
DOI: https://doi.org/10.1038/s44321-024-00073-7
[2024] Fatty Acids Play a Critical Role in Mitochondrial Oxidative Phosphorylation in Effector T Cells in Graft-versus-Host Disease
DOI: https://doi.org/10.4049/immunohorizons.2300115
[2024] The Mouse Model of Internal Capsule Demyelination: A Novel Tool for Investigating Motor Functional Changes Caused by Demyelination and for Evaluating Drugs That Promote Remyelination
DOI: https://doi.org/10.1267/ahc.24-00005
[2023] Ultrastructure of the lamprey head mesoderm reveals evolution of the vertebrate head
DOI: https://doi.org/10.1016/j.isci.2023.108338
[2023] Calcium signals tune AMPK activity and mitochondrial homeostasis in dendrites of developing neurons
DOI: https://doi.org/10.1242/dev.201930
[2023] Shared GABA transmission pathology in dopamine agonist- and antagonist-induced dyskinesia
DOI: https://doi.org/10.1016/j.xcrm.2023.101208
[2023] Unusual nuclear structures in male meiocytes of wild-type rye as revealed by volume microscopy
DOI: https://doi.org/10.1093/aob/mcad107
[2023] Three‐dimensional structural analysis of papillary thyroid carcinoma nuclei with serial block‐face scanning electron microscopy (SBF‐SEM)
DOI: https://doi.org/10.1111/pin.13329
[2023] Microglia enable cross-modal plasticity by removing inhibitory synapses
DOI: https://doi.org/10.1016/j.celrep.2023.112383
[2023] Treatment of tubular damage in high-fat-diet-fed obese mice using sodium-glucose co-transporter inhibitors
DOI: https://doi.org/10.1371/journal.pone.0281770
[2023] Cerebrospinal fluid-contacting neuron tracing reveals structural and functional connectivity for locomotion in the mouse spinal cord
DOI: https://doi.org/10.7554/elife.83108
[2023] Pharmacological treatment promoting remyelination enhances motor function after internal capsule demyelination in mice
DOI: https://doi.org/10.1016/j.neuint.2023.105505
[2023] Correlative light and electron microscopic observation of calcium phosphate particles in a mouse kidney formed under a high-phosphate diet
DOI: https://doi.org/10.1038/s41598-023-28103-3
[2023] Histological study on the reginal difference in the localization of mucosal enteric glial cells and their sheath structure in the rat intestine
DOI: https://doi.org/10.1292/jvms.23-0266
[2023] Impaired glial regulation-induced pathogenesis of glaucoma
DOI: https://doi.org/10.1254/jpssuppl.97.0_1-b-s21-3
[2023] Life Science Research for One Health: A Perspective from a Member of the Japanese Association of Anatomists
DOI: https://doi.org/10.1254/jpssuppl.97.0_1-b-s11-5
[2023] Mechanisms underlying mutant astrocyte-mediated demyelination in Alexander disease
DOI: https://doi.org/10.1254/jpssuppl.97.0_2-b-p-009
[2023] Social stress induces microglial contact with synapses, contributing to the release of heparan sulfate from synaptic proteoglycans in mice
DOI: https://doi.org/10.1254/jpssuppl.97.0_1-b-p-046
[2022] Histological study on regional specificity of the mucosal nerve network in the rat large intestine
DOI: https://doi.org/10.1292/jvms.22-0433
[2022] Roles of synaptic mitochondrial regulations for stress susceptibility
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-ss-13
[2022] Ultrastructural characteristics of oligodendrocyte precursor cells in the early postnatal mouse optic nerve observed by serial block-face scanning electron microscopy
DOI: https://doi.org/10.1371/journal.pone.0278118
[2022] CTCF loss induces giant lamellar bodies in Purkinje cell dendrites
DOI: https://doi.org/10.1186/s40478-022-01478-6
[2022] Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy
DOI: https://doi.org/10.1126/sciadv.abq1081
[2022] Synaptic pruning through glial synapse engulfment upon motor learning
DOI: https://doi.org/10.1038/s41593-022-01184-5
[2022] Thermal gradient ring reveals thermosensory changes in diabetic peripheral neuropathy in mice
DOI: https://doi.org/10.1038/s41598-022-14186-x
[2022] Budding pouches and associated bubbles: 3D visualization of exo-membrane structures in plasmodium falciparum gametocytes
DOI: https://doi.org/10.3389/fcimb.2022.962495
[2022] Dark Rearing in the Visual Critical Period Causes Structural Changes in Myelinated Axons in the Adult Mouse Visual Pathway
DOI: https://doi.org/10.1007/s11064-022-03689-8
[2022] Region specificity of fibroblast-like cells in the mucosa of the rat large intestine
DOI: https://doi.org/10.1007/s00441-022-03660-7
[2022] Whole-cell observation of ZIO-stained Golgi apparatus in rat hepatocytes with serial block-face scanning electron microscope, SBF-SEM
DOI: https://doi.org/10.1093/jmicro/dfac024
[2022] Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine
DOI: https://doi.org/10.1084/jem.20202304
[2022] Morphological Changes in Endothelial Cell Organelles in a No-Touch Saphenous Vein Graft
DOI: https://doi.org/10.21470/1678-9741-2022-0111
[2022] Microglia Enable Cross-Modal Plasticity by Removing Inhibitory Synapses
DOI: https://doi.org/10.2139/ssrn.4232469
[2022] Inflammatory responses by retinal astrocytes during pathogenesis of normal-tension glaucoma
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-o-027
[2022] Chronic social stress alters synaptic central metabolism for depression
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-yia-11
[2022] Lack of P2Y1 receptors in Müller cells causes a glaucoma-like phenotype
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-ss-05
[2022] Mechanisms underlying mutant astrocyte-mediated demyelination in Alexander disease
DOI: https://doi.org/10.1254/jpssuppl.96.0_3-b-p-220
[2022] Analysis of synaptic structural changes induced by chronic social stress and their molecular mechanisms
DOI: https://doi.org/10.1254/jpssuppl.96.0_3-b-o06-4
[2022] Non-cell-autonomous neurodegenerative mechanisms in optic neuropathy
DOI: https://doi.org/10.1254/jpssuppl.96.0_3-b-w11-1
[2021] Early reactive gliosis at optic nerve head in normal-tension glaucoma
DOI: https://doi.org/10.1254/jpssuppl.94.0_3-o-c1-3
[2021] Intercellular nuclear migration in cryofixed tobacco male meiocytes
DOI: https://doi.org/10.1007/s00709-021-01725-y
[2021] Germline development during embryogenesis of the larvacean, Oikopleura dioica
DOI: https://doi.org/10.1016/j.ydbio.2021.10.009
[2021] Advanced Electron Microscopy for Materials Science
DOI: https://doi.org/10.2320/matertrans.mt-m2021086
[2021] The Role of Galanin in Cerebellar Granule Cell Migration in the Early Postnatal Mouse during Normal Development and after Injury
DOI: https://doi.org/10.1523/jneurosci.0900-15.2021
[2021] Macroscopic detection of demyelinated lesions in mouse PNS with neutral red dye
DOI: https://doi.org/10.1038/s41598-021-96395-4
[2021] Loss of mitochondrial transcription factor A in neural stem cells leads to immature brain development and triggers the activation of the integral stress response in vivo
DOI: https://doi.org/10.1371/journal.pone.0255355
[2021] Loss of P2Y1 receptors triggers glaucoma‐like pathology in mice
DOI: https://doi.org/10.1111/bph.15637
[2021] Ddx20, <scp>DEAD</scp> box helicase 20, is essential for the differentiation of oligodendrocyte and maintenance of myelin gene expression
DOI: https://doi.org/10.1002/glia.24058
[2021] Calcium phosphate microcrystals in the renal tubular fluid accelerate chronic kidney disease progression
DOI: https://doi.org/10.1172/jci145693
[2021] Large‐scale electron microscopic volume imaging of interfascicular oligodendrocytes in the mouse corpus callosum
DOI: https://doi.org/10.1002/glia.24055
[2021] Liver-Directed AAV8 Booster Vaccine Expressing Plasmodium falciparum Antigen Following Adenovirus Vaccine Priming Elicits Sterile Protection in a Murine Model
DOI: https://doi.org/10.3389/fimmu.2021.612910
[2021] Loss of ABCA1 in astrocytes causes normal tension-glaucoma-like optic neuropathy
[2021] Serial Block-Face Scanning Electron Microscopy Reveals That Intercellular Nuclear Migration Occurs in Most Normal Tobacco Male Meiocytes
DOI: https://doi.org/10.3389/fpls.2021.672642
[2021] 3D reconstruction of structures of hatched larva and young juvenile of the larvacean Oikopleura dioica using SBF-SEM
DOI: https://doi.org/10.1038/s41598-021-83706-y
[2021] Comparison of alemtuzumab, anti-thymocyte globulin, and post-transplant cyclophosphamide for graft-versus-host disease and graft-versus-leukemia in murine models
DOI: https://doi.org/10.1371/journal.pone.0245232
[2021] Perivascular macrophages produce type I collagen around cerebral small vessels under prolonged hypertension in rats
DOI: https://doi.org/10.1007/s00418-020-01948-9
[2021] The unique physiological features of the broiler pectoralis major muscle as suggested by the three-dimensional ultrastructural study of mitochondria in type IIb muscle fibers
DOI: https://doi.org/10.1292/jvms.21-0408
[2021] Social stress induces subcellular degeneration preceding dendritic loss of prefrontal pyramidal neurons in mice
DOI: https://doi.org/10.1254/jpssuppl.94.0_3-p1-17
[2021] P2Y1 receptor is a novel target for anti-glaucoma treatment
DOI: https://doi.org/10.1254/jpssuppl.94.0_3-o-c1-4

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AI 要約（直近 5 年の研究成果）

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研究成果（87 件）

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