Eiryo Kawakami 研究室

主宰者：Eiryo Kawakami

理化学研究所・RIKEN Center for Sustainable Resource Science

兼任：理化学研究所・RIKEN Center for Integrative Medical Sciences

AI 要約（直近 5 年の研究成果）

この研究室は、医学・医療の様々な領域において、データ解析と機械学習の手法を応用することで、疾患の診断と予後予測を行う研究を展開しています。眼底画像やスキャン画像などの医療画像データ、電子カルテに記録される臨床情報、血液や組織などから得られた分子データなど、多様なタイプの医療データを対象として、深層学習や統計モデルを用いた解析を実施しています。これにより、個々の患者の病状の進展パターンを予測し、治療介入の判断をサポートするツールの開発を目指しています。具体的には、網膜変性疾患や糖尿病、感染症、がん、神経疾患など、複数の疾患を対象とした診断・予測モデルの構築が報告されています。また、遺伝子発現データや免疫細胞の特性解析を組み合わせることで、疾患の分子的メカニズムや患者の多様性（異なる病態の存在）を明らかにする研究も進めています。さらに、開発したモデルが医療現場で実際に利用できるよう、説明可能性の確保や web アプリケーション化など、社会実装に向けた工夫にも力を注いでいます。これらの取り組みを通じて、データ駆動型のアプローチにより、より精密で個別化された医療の実現を目指しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（86 件）

[2026] Metabolomic Profiling of Vitreous Humor Reveals Distinct Metabolic Signatures in Proliferative Vitreoretinopathy
DOI: https://doi.org/10.1167/iovs.67.4.21
[2026] A chromatin relay from AIRE to ETS transcription factors sustains peripheral antigen expression in the thymic mimetic cells to ensure central tolerance
DOI: https://doi.org/10.64898/2026.02.03.703355
[2026] Relative <scp>MYC</scp> downregulation and <scp>RUNX2</scp> upregulation orchestrate partial epithelial‐mesenchymal transition in colorectal cancer tumor budding and poorly differentiated clusters
DOI: https://doi.org/10.1002/path.70013
[2026] 2383-P: Machine Learning–Based Clustering to Predict Functional Beta-Cell Depletion in Type 1 Diabetes
DOI: https://doi.org/10.2337/db26-2383-p
[2026] Leveraging large scale deep learning models for diagnosis and visual outcome prediction in retinitis pigmentosa
DOI: https://doi.org/10.1038/s41746-025-02311-9
[2026] Emulsion-Templated Gel Embedding: A Microfluidics-Free Method for Scalable Cell Encapsulation in Hydrogel Microcapsules
DOI: https://doi.org/10.1021/acsbiomaterials.5c02129
[2026] Use of Commercially Available Large Language Models to Generate Information Leaflets on Post–Intensive Care Syndrome: Clinical Utility Assessment
DOI: https://doi.org/10.2196/81606
[2026] Reciprocal Regulation of <scp>GLI1</scp> and <scp>GLI3</scp> Fine Tunes the Pathogenic Behavior of Synovial Fibroblasts in Rheumatoid Arthritis
DOI: https://doi.org/10.1111/1756-185x.70690
[2025] An unbiased tissue transcriptome analysis identifies potential markers for skin phenotypes and therapeutic responses in atopic dermatitis
DOI: https://doi.org/10.1038/s41467-025-59340-x
[2025] Elucidating synergistic risk factors among comorbidity combinations for nephrotic syndrome based on time series statistical evaluation
DOI: https://doi.org/10.1016/j.dmpk.2025.101170

続きを表示（残り 76 件）

[2025] Explainable Machine Learning Framework for Dynamic Monitoring of Disease Prognostic Risk: Retrospective Cohort Study
DOI: https://doi.org/10.2196/65585
[2025] p53-inducible lncRNA LOC644656 causes genotoxic stress-induced stem cell maldifferentiation and cancer chemoresistance
DOI: https://doi.org/10.1038/s41467-025-59886-w
[2025] Rigorous multiple statistical test unveils combinations of preceding diseases at risk for the development of adult nephrotic syndrome
DOI: https://doi.org/10.1016/j.compbiomed.2025.110360
[2025] Interaction Between Lifestyle, Immunity and Gut Microbiota in Milk Allergy Children
DOI: https://doi.org/10.1111/cea.70080
[2025] Multilevel Factors and Indicators of Atypical Neurodevelopment During Early Infancy in Japan: Prospective, Longitudinal, Observational Study
DOI: https://doi.org/10.2196/58337
[2025] UMAP Clustering Unveiled Patterns of IgE Sensitization and Allergic Disease Progression in Asian Childhood: A Birth Cohort (T-Child Study)
DOI: https://doi.org/10.1016/j.jaci.2024.12.227
[2025] Neutrophil adhesion to vessel walls impairs pulmonary circulation in COVID-19 pathology
DOI: https://doi.org/10.1038/s41467-024-55272-0
[2025] Prediction of cccDNA dynamics in hepatitis B patients by a combination of serum surrogate markers
DOI: https://doi.org/10.1371/journal.pcbi.1012615
[2025] Multifactorial Assessment of Complication Risks in Embolization for Ruptured Cerebral Aneurysm
DOI: https://doi.org/10.5797/jnet.oa.2024-0095
[2025] Hepatic leukemia factor directs tissue residency of proinflammatory memory CD4 <sup>+</sup> T cells
DOI: https://doi.org/10.1126/science.adp0714
[2025] Accurate prediction of hypoglycemia and hyperglycemia using machine learning in critically ill patients
DOI: https://doi.org/10.1038/s41598-025-29860-z
[2025] Development of Prognostic Models for Bladder and Bowel Dysfunction in Traumatic Spinal Cord Injury Patients Using Machine Learning
DOI: https://doi.org/10.1177/08977151251401550
[2025] Dynamic network biomarker analysis reveals predisease state in atopic dermatitis
DOI: https://doi.org/10.1016/j.jid.2025.10.579
[2025] The Cutting Edge of AI in Medicine: Data Science Transforming Diagnosis and Treatment
DOI: https://doi.org/10.2468/jbes.76.247
[2025] Artificial intelligence and big data: Reshaping allergy research and patient care
DOI: https://doi.org/10.1016/j.alit.2025.09.001
[2025] Rapid and Slow Progressors Toward β-Cell Depletion and Their Predictors in Type 1 Diabetes: Prospective Longitudinal Study in Japanese Type 1 Diabetes (TIDE-J)
DOI: https://doi.org/10.2337/dc25-0579
[2024] Muscle Tissue Transcriptome of Idiopathic Inflammatory Myopathy Reflects the Muscle Damage Process by Monocytes and Presence of Skin Lesions
DOI: https://doi.org/10.1002/art.42972
[2024] Development of a robust predictive model for neutropenia after esophageal cancer chemotherapy using GLMMLasso
DOI: https://doi.org/10.1007/s11096-024-01836-5
[2024] Comparative analysis of aldosterone and renin assays for primary aldosteronism screening
DOI: https://doi.org/10.1038/s41598-024-75645-1
[2024] RelB and C/EBPα critically regulate the development of Peyer’s patch mononuclear phagocytes
DOI: https://doi.org/10.1016/j.mucimm.2024.10.005
[2024] Deciphering craniopharyngioma subtypes: Single-cell analysis of tumor microenvironment and immune networks
DOI: https://doi.org/10.1016/j.isci.2024.111068
[2024] 5) The Future of Internal Medicine Co-created with AI
DOI: https://doi.org/10.2169/naika.113.1621
[2024] Machine learning-based reproducible prediction of type 2 diabetes subtypes
DOI: https://doi.org/10.1007/s00125-024-06248-8
[2024] Comparison of machine-learning and logistic regression models for prediction of 30-day unplanned readmission in electronic health records: A development and validation study
DOI: https://doi.org/10.1371/journal.pdig.0000578
[2024] Host-derived protein profiles of human neonatal meconium across gestational ages
DOI: https://doi.org/10.1038/s41467-024-49805-w
[2024] Sodium–glucose cotransporter 2 inhibitor therapy reduces the administration frequency of steroid injection in patients with diabetic macular edema: A cohort study using the Japanese health insurance claims database
DOI: https://doi.org/10.1111/jdi.14253
[2024] Memory CD8 T cells are vulnerable to chronic IFN-γ signals but not to CD4 T cell deficiency in MHCII-deficient mice
DOI: https://doi.org/10.1038/s41467-024-48704-4
[2024] BARToM: a Transformer-based approach for multimodal electronic health records transformation
DOI: https://doi.org/10.1145/3673971.3673999
[2024] ARID5B is a negative modulator of IL-6 production in rheumatoid arthritis synovial fibroblasts
DOI: https://doi.org/10.1080/25785826.2024.2346956
[2024] Preoperative prediction for periprosthetic bone loss and individual evaluation of bisphosphonate effect after total hip arthroplasty using artificial intelligence
DOI: https://doi.org/10.1302/2046-3758.134.bjr-2023-0188.r1
[2024] Dimension reduction of microbiome data linked Bifidobacterium and Prevotella to allergic rhinitis
DOI: https://doi.org/10.1038/s41598-024-57934-x
[2024] Generative artificial intelligence and non-pharmacological bias: an experimental study on cancer patient sexual health communications
DOI: https://doi.org/10.1136/bmjhci-2023-100924
[2024] 5) The Future of Internal Medicine Co-created with AI
DOI: https://doi.org/10.2169/naika.113.104b
[2024] Sodium‐glucose co‐transporter 2 inhibitor therapy reduces the administration frequency of anti‐vascular endothelial growth factor agents in patients with diabetic macular oedema with a history of anti‐vascular endothelial growth factor agent use: A cohort study using the Japanese health insurance claims database
DOI: https://doi.org/10.1111/dom.15454
[2023] Explainable Machine Learning Classification to Identify Vulnerable Groups Among Parenting Mothers: Web-Based Cross-Sectional Questionnaire Study
DOI: https://doi.org/10.2196/47372
[2023] Best practices for multimodal clinical data management and integration: An atopic dermatitis research case
DOI: https://doi.org/10.1016/j.alit.2023.11.006
[2023] Developing Medical Education Curriculum Reform Strategies to Address the Impact of Generative AI: Qualitative Study
DOI: https://doi.org/10.2196/53466
[2023] EP169/#411 Machine learning method for differential diagnosis and prognosis prediction for early-stage uterine sarcoma using preoperative blood biomarker and age
DOI: https://doi.org/10.1136/ijgc-2023-igcs.259
[2023] Multifaceted analysis of cross-tissue transcriptomes reveals phenotype–endotype associations in atopic dermatitis
DOI: https://doi.org/10.1038/s41467-023-41857-8
[2023] Non-negative tensor factorization workflow for time series biomedical data
DOI: https://doi.org/10.1016/j.xpro.2023.102318
[2023] Synovial Tissue Heterogeneity in Japanese Patients With Rheumatoid Arthritis Elucidated Using a <scp>Cell‐Type</scp> Deconvolution Approach
DOI: https://doi.org/10.1002/art.42642
[2023] Predicting dry weight change in Hemodialysis patients using machine learning
DOI: https://doi.org/10.1186/s12882-023-03248-5
[2023] FsNet: Feature Selection Network on High-dimensional Biological Data
DOI: https://doi.org/10.1109/ijcnn54540.2023.10191985
[2023] d-Alanine Affects the Circadian Clock to Regulate Glucose Metabolism in the Kidney
DOI: https://doi.org/10.34067/kid.0000000000000345
[2023] Protocol to acquire time series data on adverse reactions following vaccination using a smartphone or web-based platform
DOI: https://doi.org/10.1016/j.xpro.2023.102284
[2023] Monitoring of blood biochemical markers for periprosthetic joint infection using ensemble machine learning and UMAP embedding
DOI: https://doi.org/10.1007/s00402-023-04898-8
[2023] Machine-learning predicts time-series prognosis factors in metastatic prostate cancer patients treated with androgen deprivation therapy
DOI: https://doi.org/10.1038/s41598-023-32987-6
[2023] Machine Learning Approach to Stratify Complex Heterogeneity of Chronic Heart Failure: A Report from the CHART-2 Study
DOI: https://doi.org/10.1002/ehf2.14288
[2023] A simple scoring model based on machine learning predicts intravenous immunoglobulin resistance in Kawasaki disease
DOI: https://doi.org/10.1007/s10067-023-06502-1
[2023] The Future of Medicine and Medical Care co-created with AI and Human
DOI: https://doi.org/10.1272/manms.19.350
[2022] Detecting Time-Evolving Phenotypic Components of Adverse Reactions Against BNT162b2 mRNA SARS-CoV-2 Vaccine Via Non-Negative Tensor Factorization
DOI: https://doi.org/10.2139/ssrn.4041409
[2022] Prediction of Change in Pelvic Tilt After Total Hip Arthroplasty Using Machine Learning
DOI: https://doi.org/10.1016/j.arth.2022.06.020
[2022] Proteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors
DOI: https://doi.org/10.1038/s42003-022-04272-1
[2022] Statistical Analysis of Mortality Rates of Coronavirus Disease 2019 (COVID-19) Patients in Japan Across the 4C Mortality Score Risk Groups, Age Groups, and Epidemiological Waves: A Report From the Nationwide COVID-19 Cohort
DOI: https://doi.org/10.1093/ofid/ofac638
[2022] 176 C10orf99/2610528A11Rik induces keratinocyte proinflammatory response and regulates lipid metabolism and barrier formation of the skin
DOI: https://doi.org/10.1016/j.jid.2022.09.187
[2022] Predicting pathological highly invasive lung cancer from preoperative [18F]FDG PET/CT with multiple machine learning models
DOI: https://doi.org/10.1007/s00259-022-06038-7
[2022] MicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway
DOI: https://doi.org/10.1038/s41598-022-23205-w
[2022] The Histone Methyltransferase SETD8 Regulates the Expression of Tumor Suppressor Genes via H4K20 Methylation and the p53 Signaling Pathway in Endometrial Cancer Cells
DOI: https://doi.org/10.3390/cancers14215367
[2022] Table of Contents
DOI: https://doi.org/10.1016/s0022-202x(22)02589-1
[2022] Detecting time-evolving phenotypic components of adverse reactions against BNT162b2 SARS-CoV-2 vaccine via non-negative tensor factorization
DOI: https://doi.org/10.1016/j.isci.2022.105237
[2022] Prediction algorithm for ICU mortality and length of stay using machine learning
DOI: https://doi.org/10.1038/s41598-022-17091-5
[2022] 424 C10orf99 governs keratinocyte inflammatory response and barrier formation of the skin
DOI: https://doi.org/10.1016/j.jid.2022.05.433
[2022] Microbiota-Independent Spontaneous Dermatitis Associated with Increased Sebaceous Lipid Production in Tmem79-Deficient Mice
DOI: https://doi.org/10.1016/j.jid.2022.06.003
[2022] Diagnosis of Atrial Fibrillation Using Machine Learning With Wearable Devices After Cardiac Surgery: Algorithm Development Study
DOI: https://doi.org/10.2196/35396
[2022] Development and validation of machine learning prediction model for post-rehabilitation functional outcome after intracerebral hemorrhage
DOI: https://doi.org/10.1016/j.inat.2022.101560
[2022] Multiple nutritional and gut microbial factors associated with allergic rhinitis: the Hitachi Health Study
DOI: https://doi.org/10.1038/s41598-022-07398-8
[2022] C10orf99/GPR15L Regulates Proinflammatory Response of Keratinocytes and Barrier Formation of the Skin
DOI: https://doi.org/10.3389/fimmu.2022.825032
[2021] 062 Classification of atopic dermatitis patients based on skin properties
DOI: https://doi.org/10.1016/j.jid.2021.08.064
[2021] Associations of ultrasound-based inflammation patterns with peripheral innate lymphoid cell populations, serum cytokines/chemokines, and treatment response to methotrexate in rheumatoid arthritis and spondyloarthritis
DOI: https://doi.org/10.1371/journal.pone.0252116
[2021] Staphylococcus cohnii is a potentially biotherapeutic skin commensal alleviating skin inflammation
DOI: https://doi.org/10.1016/j.celrep.2021.109052
[2021] Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia
DOI: https://doi.org/10.1016/j.ebiom.2021.103235
[2021] Metabolic remodeling in the right ventricle of rats with severe pulmonary arterial hypertension
DOI: https://doi.org/10.3892/mmr.2021.11866
[2021] Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes
DOI: https://doi.org/10.1136/jitc-2021-002954
[2021] The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation
DOI: https://doi.org/10.1084/jem.20201690
[2021] Spatiotemporal Components of Adverse Reactions&nbsp;Against BNT162b2&nbsp;mRNA SARS-CoV-2 Vaccine Reflect Different Immunological Processes
DOI: https://doi.org/10.2139/ssrn.3903937
[2021] Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes
DOI: https://doi.org/10.1038/s41467-021-24894-z

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（86 件）

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