Hirosato Takikawa 研究室

主宰者：Hirosato Takikawa

東京大学

AI 要約（直近 5 年の研究成果）

本研究室は、天然物の全合成と生合成研究を通じて、生物活性を持つ化合物の構造解明と機能理解に取り組んでいます。研究の対象は、医療や農業に応用できるポテンシャルを持つ天然物の多岐にわたります。例えば、植物ホルモンであるストリゴラクトン類、骨再生に関わる生物活性物質、抗菌性ペプチド、香気成分、殺ダニ活性物質など、多様な生物機能を持つ物質が対象となっています。これらの化合物について、研究室では有機合成化学の手法を駆使した全合成を行うことで、その立体構造を決定し、天然物と合成物の物理的性質を比較して絶対配置を確認しています。合成では、不斉合成反応、遷移金属触媒反応、環化反応などの先進的な有機合成手法を活用しています。同時に、遺伝子組換えやタンパク質解析などの生化学的アプローチを組み合わせ、これらの天然物がどのような生物学的過程で生成されるのかを明らかにしています。特に植物の二次代謝産物に関しては、その生合成経路に関与する酵素を同定し、その触媒機構を解析することで、植物が多様な生物活性物質をどのように作り分けているかを解明しようとしています。このように合成と生合成の両面からアプローチすることで、天然物の構造と機能の関係を深く理解し、それを農業化学や医療応用へ展開できる基礎を築いています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（50 件）

[2026] Total synthesis of (±)-8-methoxybicolosin C
DOI: https://doi.org/10.1016/j.tet.2026.135328
[2026] Concise and enantioselective synthesis of (+)-SDEF 678 metabolite and (+)-speciosins A, C, and L
DOI: https://doi.org/10.1093/bbb/zbag030
[2026] Improved formal synthesis of orobanchol and novel simultaneous synthesis of 4-deoxyorobanchol and 5-deoxystrigol with high enantiomeric purity
DOI: https://doi.org/10.1016/j.tet.2026.135206
[2025] Asymmetric Total Synthesis of (+)-Karanone: An Important Aroma Compound in Fine Agarwood
DOI: https://doi.org/10.1021/acs.jnatprod.5c00838
[2025] Human ovulatory phase-increasing odors cause positive emotions and stress-suppressive effects in males
DOI: https://doi.org/10.1016/j.isci.2025.113087
[2025] Tandem gene duplication drives the molecular evolution of orobanchol into a novel noncanonical strigolactone with weak germination-inducing activity toward root parasitic weeds in cowpea
DOI: https://doi.org/10.1093/pcp/pcaf048
[2025] Synthesis of 5-epi- and 10-epi-β-selinenes and 5-epi- and 10-epi-costals and their acaricidal activity against Varroa destructor
DOI: https://doi.org/10.1093/bbb/zbaf034
[2025] Twists and turns in natural product synthesis
DOI: https://doi.org/10.1584/jjpestics.w25-02
[2025] CYP722A1-mediated 16-hydroxylation of carlactonoic acid regulates the floral transition in Arabidopsis
DOI: https://doi.org/10.1093/pcp/pcaf022
[2025] Synthesis of stagonosporyne G from (−)-D-quinic acid
DOI: https://doi.org/10.1016/j.tet.2025.134488

続きを表示（残り 40 件）

[2025] Total Synthesis and Complete Stereochemical Assignment of Amphirionin‐5, a Potent Natural Osteoblasts Proliferator
DOI: https://doi.org/10.1002/ceur.202500345
[2025] Synthesis of calyxosides, two-headed glycosphingolipids isolated from marine sponges, and their α-glycoside analogs
DOI: https://doi.org/10.1016/j.tet.2025.134453
[2025] An efficient stereochemical elucidation of the aromatic polyketide NFAT-133 using the novel NOE quantification combined with n J H-H and n J C-H coupling constants
DOI: https://doi.org/10.1080/14786419.2025.2570506
[2025] JBIR-160–166 Obtained from the Heterologous Expression of a Cryptic Gene Cluster in Kitasatospora setae
DOI: https://doi.org/10.1021/acs.orglett.5c03682
[2024] Insights into stereoselective ring formation in canonical strigolactone: Identification of a dirigent domain-containing enzyme catalyzing orobanchol synthesis
DOI: https://doi.org/10.1073/pnas.2313683121
[2024] Asymmetric synthesis of orobanchol, a representative canonical strigolactone, based on enzymatic kinetic resolution and its conversion to naturally occurring orobanchol derivatives
DOI: https://doi.org/10.1016/j.tet.2024.134016
[2024] 2-oxoglutarate-dependent dioxygenases and BAHD acyltransferases drive the structural diversification of orobanchol in Fabaceae plants
DOI: https://doi.org/10.3389/fpls.2024.1392212
[2024] Synthesis of the proposed structure for artemisidiyne A, a cytotoxic compound isolated from the white mugwort, Artemisia lactiflora, and proposal for its structural revision
DOI: https://doi.org/10.1016/j.tetlet.2024.155020
[2024] Synthetic studies on biologically active natural products with potential as agrochemicals
DOI: https://doi.org/10.1584/jpestics.j24-01
[2024] Synthesis and structural confirmation of artemisidiyne A, a cytotoxic compound isolated from the white mugwort, Artemisia lactiflora
DOI: https://doi.org/10.1016/j.tet.2024.134190
[2024] Absolute Configuration of 4-Chloroisoleucine in Cyclolithistide A: An Antifungal Peptide Lactone Discovered in Marine Lithistid Sponges
DOI: https://doi.org/10.1021/acs.joc.4c00913
[2023] Novel and efficient stereoselective synthesis of (±)-orobanchol, a representative canonical strigolactone, based on acid-mediated cascade cyclization
DOI: https://doi.org/10.1016/j.tetlet.2023.154454
[2023] Synthesis of (±)-zeapyranolactone, a noncanonical strigolactone isolated from maize, and determination of its overall relative configuration
DOI: https://doi.org/10.1016/j.tetlet.2023.154695
[2023] Discovery of strigol synthase from cotton (<scp>Gossypium hirsutum</scp>): The enzyme behind the first identified germination stimulant for Striga
DOI: https://doi.org/10.1002/ppp3.10420
[2023] A step-economical divergent approach to isoflavenes based on Suzuki–Miyaura cross coupling of a 3-boryl-2H-chromene with aryl bromides: application to total synthesis of isoflavonoid natural products
DOI: https://doi.org/10.1093/bbb/zbad076
[2023] Syntheses of (+)-costic acid and structurally related eudesmane sesquiterpenoids and their biological evaluations as acaricidal agents against Varroa destructor
DOI: https://doi.org/10.1584/jpestics.d23-029
[2023] Convergent radical-free synthesis of isoflavanquinones: Divergent total synthesis of abruquinones B, E, and P
DOI: https://doi.org/10.1016/j.tet.2023.133362
[2023] New synthesis of (±)-karanone, an important aroma compound in agarwood
DOI: https://doi.org/10.1093/bbb/zbad009
[2023] Mechanisms of Sugar Aminotransferase-like Enzymes to Synthesize Stereoisomers of Non-proteinogenic Amino Acids in Natural Product Biosynthesis
DOI: https://doi.org/10.1021/acschembio.2c00823
[2022] Overview of Kenji Mori’s pheromone synthesis series
DOI: https://doi.org/10.1584/jpestics.d22-062
[2022] Identification of novel canonical strigolactones produced by tomato
DOI: https://doi.org/10.3389/fpls.2022.1064378
[2022] Molecular Basis for Enzymatic Aziridine Formation via Sulfate Elimination
DOI: https://doi.org/10.1021/jacs.2c07243
[2022] Identification of 6-epi-heliolactone as a biosynthetic precursor of avenaol in Avena strigosa
DOI: https://doi.org/10.1093/bbb/zbac069
[2022] Syntheses of three 8-methoxyisoflavans from newly developed 7-benzyloxy-3-chloro-8-methoxy-2H-chromene as the precursor
DOI: https://doi.org/10.1016/j.tet.2022.132714
[2022] Synthesis and biological evaluation of cajaninstilbene acid and amorfrutins A-D as cytotoxic agents against human pancreatic carcinoma PANC-1 cells
DOI: https://doi.org/10.1093/bbb/zbac025
[2021] Enantioselective synthesis of 6-methyloctanal and 8-methyldecanal, the characteristic aroma components in yuzu Citrus junos, and the analysis of their enantiomeric compositions in yuzu essential oil
DOI: https://doi.org/10.1093/bbb/zbab196
[2021] Memories of Professor Kenji Mori, the Giant of Pheromone Synthesis
DOI: https://doi.org/10.1007/s10886-021-01327-1
[2021] Synthesis of racemic orobanchols via acid-mediated cascade cyclization: Insight into the process of BC-ring formation in strigolactone biosynthesis
DOI: https://doi.org/10.1016/j.tetlet.2021.153469
[2021] Specific methylation of (11R)-carlactonoic acid by an Arabidopsis SABATH methyltransferase
DOI: https://doi.org/10.1007/s00425-021-03738-6
[2021] Studies on Strigolactone Based on Synthetic Organic Chemistry
DOI: https://doi.org/10.5059/yukigoseikyokaishi.79.819
[2021] Structural and configurational diversity of strigolactones
DOI: https://doi.org/10.1584/jpestics.w21-28
[2021] Homophymamide A, Heterodetic Cyclic Tetrapeptide from a Homophymia sp. Marine Sponge: A Cautionary Note on Configurational Assignment of Peptides That Contain a Ureido Linkage
DOI: https://doi.org/10.1021/acs.jnatprod.1c00336
[2021] JBIR-155, a Specific Class D β-Lactamase Inhibitor of Microbial Origin
DOI: https://doi.org/10.1021/acs.orglett.1c01352
[2021] Concise enantioselective synthesis of wine lactone via intramolecular Diels–Alder reaction
DOI: https://doi.org/10.1093/bbb/zbab045
[2021] Studies on strigolactone BC-ring formation: Chemical conversion of an 18-hydroxycarlactonoate derivative into racemic 4-deoxyorobanchol/5-deoxystrigol via the acid-mediated cascade cyclization
DOI: https://doi.org/10.1016/j.tetlet.2021.152922
[2021] Azoxystrobin amine: A novel azoxystrobin degradation product from Bacillus licheniformis strain TAB7
DOI: https://doi.org/10.1016/j.chemosphere.2021.129663
[2021] Stereoselective Synthesis of (2S,6R)‐Diamino‐(5R,7)‐dihydroxy‐heptanoic Acid (DADH): An Unusual Amino Acid from Streptomyces sp. SANK 60404
DOI: https://doi.org/10.1002/ejoc.202001646
[2021] Identification and characterization of sorgomol synthase in sorghum strigolactone biosynthesis
DOI: https://doi.org/10.1093/plphys/kiaa113
[2021] Unified synthesis and assessment of tumor cell migration inhibitory activity of optically active UTKO1, originally designed moverastin analog
DOI: https://doi.org/10.1093/bbb/zbaa062
[2021] In Memory of Professor Kenji Mori
DOI: https://doi.org/10.1093/bbb/zbaa073

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（50 件）

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