Takeshi Ikeuchi 研究室

主宰者：Takeshi Ikeuchi

新潟大学・Niigata University Medical and Dental Hospital

AI 要約（直近 5 年の研究成果）

本研究室は、神経変性疾患の診断と病態解明を中心に研究を進めています。特にアルツハイマー病をはじめとする認知症疾患について、患者の脳脊髄液や血液中の生化学マーカー測定と遺伝学的解析を組み合わせて調査しています。アルツハイマー病関連タンパク質の蓄積メカニズムや、症状発症前の早期段階での病態変化を明らかにすることで、より早期の診断や治療開発につなげる研究を実施しています。また、遺伝性アルツハイマー病の患者を対象とした国際的な大規模研究に参画し、遺伝子変異と発症年齢の関連性の解明にも取り組んでいます。さらに、アルツハイマー病以外の神経変性疾患、パーキンソン病や進行性核上麻痺などの運動障害疾患、前頭側頭葉変性症といった認知機能障害をもたらす疾患についても、その診断マーカーや病態関連因子の探索を行っています。これらの研究では、遺伝子解析、神経画像検査、脳脊髄液バイオマーカーの測定を統合的に活用し、各疾患の特徴を明らかにしています。加えて、より稀少な遺伝性疾患や新生児の代謝異常、脳病理の詳細な検討を含む臨床病理学的研究も実施しており、診断が難しい症例の疾患メカニズム解明に貢献しています。これら多角的なアプローチを通じて、神経変性疾患全般の病態理解を深め、患者の適切な診断と治療法開発を支援することを目指しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（100 件）

[2026] CCN1/Cyr61 associates with β-amyloid levels in human cerebrospinal fluids
DOI: https://doi.org/10.1016/j.isci.2026.116244
[2026] Post-mortem diagnosis of CACT deficiency with a novel SLC25A20 variant
DOI: https://doi.org/10.1038/s41439-026-00354-2
[2026] Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease
DOI: https://doi.org/10.1212/wnl.0000000000214804
[2026] Retraction notice to “Generation of a gene-corrected human isogenic iPSC line from an Alzheimer’s disease iPSC line carrying the PSEN1 H163R mutation” [Stem Cell Res. 79 (2024) 103495]
DOI: https://doi.org/10.1016/j.scr.2026.103956
[2026] Camptodactyly and Early‐Onset Scoliosis in Snijders Blok–Campeau Syndrome
DOI: https://doi.org/10.1155/crig/9968980
[2025] Leptin and inflammatory pathways in the Alzheimer's disease continuum: Implications for glial activation and neuropsychiatric symptoms
DOI: https://doi.org/10.1016/j.bbih.2025.101018
[2025] Argyrophilic grain disease: epidemiology and association with cognitive decline and parkinsonism
DOI: https://doi.org/10.1093/braincomms/fcaf352
[2025] Association of rare APOE missense variants with Alzheimer's disease in the Japanese population
DOI: https://doi.org/10.1177/13872877251340710
[2025] Ubiquitin–proteasome system in the different stages of dominantly inherited Alzheimer's disease
DOI: https://doi.org/10.1002/alz.70243
[2025] Nation-wide Japanese FTD consortium FTLD-J: Utility of case review meetings
DOI: https://doi.org/10.1016/j.inpsyc.2025.100078

続きを表示（残り 90 件）

[2025] Iatrogenic cerebral amyloid angiopathy 30 years after childhood cadaveric dura mater transplantation: a case report
DOI: https://doi.org/10.1186/s12883-025-04506-9
[2025] Early increase of the synaptic blood marker β‐synuclein in asymptomatic autosomal dominant Alzheimer's disease
DOI: https://doi.org/10.1002/alz.70146
[2025] Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial
DOI: https://doi.org/10.1016/s1474-4422(25)00024-9
[2025] Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia
DOI: https://doi.org/10.1038/s41591-025-03494-0
[2025] The landscape of autosomal-dominant Alzheimer’s disease: global distribution and age of onset
DOI: https://doi.org/10.1093/brain/awaf038
[2025] Novel Aspects of Hereditary Spastic Paraplegia: A Clinicopathologic and Biochemical Study of a Patient With a Heterozygous GCH1 Variant
DOI: https://doi.org/10.1111/nan.70006
[2025] Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer’s disease
DOI: https://doi.org/10.1186/s13195-024-01659-6
[2025] Elucidating the role of APOE ε4 gene variants in the clinical manifestation of Parkinson's disease
DOI: https://doi.org/10.3389/fnagi.2025.1632480
[2025] Association of Plasma Placental Growth Factor with White Matter Hyperintensities in Alzheimer’s Disease
DOI: https://doi.org/10.3390/biom15101367
[2025] The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology
DOI: https://doi.org/10.1002/alz.70689
[2025] Plasma IL-6 Levels as a Biomarker for Behavioral Changes in Alzheimer’s Disease
DOI: https://doi.org/10.1159/000547726
[2024] Conversion therapy with pembrolizumab for a peritoneal metastasis of rectal cancer causing hydronephrosis in a patient with Lynch syndrome
DOI: https://doi.org/10.1007/s12328-024-01931-0
[2024] A severe case of cardiospondylocarpofacial syndrome with a novel MAP3K7 variant
DOI: https://doi.org/10.1038/s41439-024-00265-0
[2024] Missense mutation of NRAS is associated with malignant progression in neurocutaneous melanosis
DOI: https://doi.org/10.1186/s40478-024-01723-0
[2024] Advertisement by medical facilities as an opportunity route of APOE genetic testing in Japan: a website analysis
DOI: https://doi.org/10.1007/s12687-024-00697-9
[2024] Clinical and neuropsychological features and changes to regional cerebral blood flow in patients with Parkinson’s disease dementia
DOI: https://doi.org/10.5692/clinicalneurol.cn-001968
[2024] Japanese longitudinal biomarker study in progressive supranuclear palsy and corticobasal degeneration: Clinical features of the first registered patients and short-term follow-up analysis
DOI: https://doi.org/10.1016/j.prdoa.2024.100279
[2024] Long-standing preservation of levodopa response in progressive supranuclear palsy
DOI: https://doi.org/10.1016/j.jns.2024.123203
[2024] A case of cerebral amyloid angiopathy with ipsilateral tau and contralateral amyloid PET uptake related to cadaveric dura mater implanted in childhood
DOI: https://doi.org/10.1007/s00259-024-07030-z
[2024] Utility of Cerebrospinal Fluid Transferrin Receptor per Ferritin Ratio in Progressive Supranuclear Palsy
DOI: https://doi.org/10.1002/mdc3.14313
[2024] Neonatal myoclonus in Bryant-Li-Bhoj syndrome associated with a novel H3F3A variant
DOI: https://doi.org/10.1038/s41439-024-00303-x
[2024] APOE rare missense variants in Japan
DOI: https://doi.org/10.1002/alz.088676
[2024] Omics analysis of Alzheimer’s disease stratified by the microglial polygenic effect
DOI: https://doi.org/10.1002/alz.088489
[2024] CSF α‐synuclein reflects neurodegeneration in Alzhiemer's disease
DOI: https://doi.org/10.1002/alz.083793
[2024] Characteristics of cerebrospinal fluid biomarkers/ imaging findings in patient with amyloid‐negative dementia ∼second report∼
DOI: https://doi.org/10.1002/alz.088068
[2024] Application of blood biomarkers for the future anti‐Aβ antibody therapy in Japan
DOI: https://doi.org/10.1002/alz.084859
[2024] Clinical Characteristics of Progressive Supranuclear Palsy Subtypes Defined by AT(N) CSF Biomarkers
DOI: https://doi.org/10.1002/alz.084808
[2024] Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease
DOI: https://doi.org/10.1038/s41467-024-52937-8
[2024] Pure argyrophilic grain disease revisited: independent effects on limbic, neocortical, and striato-pallido-nigral degeneration and the development of dementia in a series with a low to moderate Braak stage
DOI: https://doi.org/10.1186/s40478-024-01828-6
[2024] Conventional magnetic resonance imaging key features for distinguishing pathologically confirmed corticobasal degeneration from its mimics: a retrospective analysis of the J-VAC study
DOI: https://doi.org/10.1007/s00234-024-03432-w
[2024] RETRACTED: Generation of a gene-corrected human isogenic iPSC line from an Alzheimer’s disease iPSC line carrying the PSEN1 H163R mutation
DOI: https://doi.org/10.1016/j.scr.2024.103495
[2024] Neurofibrillary tangle-predominant dementia followed by amyloid β pathology: a clinico-radio-pathological case providing insights into current disease-modifying therapeutic strategy
DOI: https://doi.org/10.1186/s40478-024-01815-x
[2024] A patient with neuronal intranuclear inclusion disease developed encephalitis‐like symptoms after cerebral angiography
DOI: https://doi.org/10.1111/ncn3.12839
[2024] Trait-anxiety and glial-related neuroinflammation of the amygdala and its associated regions in Alzheimer's disease: A significant correlation
DOI: https://doi.org/10.1016/j.bbih.2024.100795
[2024] Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging
DOI: https://doi.org/10.1016/j.ebiom.2024.105080
[2024] Clinical presentation and diagnosis of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia: a literature analysis of case studies
DOI: https://doi.org/10.3389/fneur.2024.1320663
[2024] Polygenic effects on the risk of Alzheimer’s disease in the Japanese population
DOI: https://doi.org/10.1186/s13195-024-01414-x
[2023] Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease
DOI: https://doi.org/10.1038/s41591-023-02476-4
[2023] An autopsy case of diffuse atypical argyrophilic grain disease (<scp>AGD</scp>) with presenile onset and three‐year course of motor and cognitive impairment
DOI: https://doi.org/10.1111/neup.12949
[2023] Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease
DOI: https://doi.org/10.1186/s13024-023-00688-3
[2023] Application of AT(N) classification using two CSF A‐markers and two CSF N‐markers to Alzheimer’s Clinical Syndrome (ACS) and non‐ACS
DOI: https://doi.org/10.1002/alz.071823
[2023] Omics analysis of Alzheimer’s disease stratified by the microglial polygenic effect
DOI: https://doi.org/10.1002/alz.075550
[2023] 10141-GMC-13 MULTIREGIONAL GENOMIC ANALYSIS: A NOVEL APPROACH FOR DETECTING PATHOGENIC DRIVER MUTATION ASSOCIATED WITH MALIGNANT PROGRESSION IN NEUROCUTANEOUS MELANOSIS
DOI: https://doi.org/10.1093/noajnl/vdad141.057
[2023] AT(N) Classification and Clinical Characterization by CSF Biomarkers in Patients with Corticobasal Syndrome
DOI: https://doi.org/10.1002/alz.072618
[2023] Evaluation of performance of genoSCORETM for predicting onset of Alzheimer’s disease in a Japanese population
DOI: https://doi.org/10.1002/alz.074095
[2023] Characteristics of cerebrospinal fluid biomarkers/imaging findings in ptaients with amyloid PET‐negative dementia
DOI: https://doi.org/10.1002/alz.081680
[2023] Genetic characterization of NOTCH2NLC repeat expansion in patients with neuronal intranuclear inclusion disease (NIID)
DOI: https://doi.org/10.1002/alz.078106
[2023] Characteristics of cerebrospinal fluid biomarkers/imaging findings in ptaients with amyloid PET‐negative dementia
DOI: https://doi.org/10.1002/alz.075466
[2023] P17: What happens if your colleague was the first person who notice that you have early-onset dementia?
DOI: https://doi.org/10.1017/s1041610223003940
[2023] <scp>T1</scp> and <scp>FLAIR</scp> signal intensities are related to tau pathology in dominantly inherited Alzheimer disease
DOI: https://doi.org/10.1002/hbm.26514
[2023] Investigation of sex differences in mutation carriers of the Dominantly Inherited Alzheimer Network
DOI: https://doi.org/10.1002/alz.13460
[2023] Neuroimaging biomarkers of glial activation for predicting the annual cognitive function decline in patients with Alzheimer’s disease
DOI: https://doi.org/10.1016/j.bbi.2023.08.027
[2023] Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls
DOI: https://doi.org/10.1038/s41598-023-38893-1
[2023] IgG index of cerebrospinal fluid can reflect pathophysiology associated with Lewy bodies in Parkinson's disease
DOI: https://doi.org/10.1016/j.jns.2023.120760
[2023] Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN)
DOI: https://doi.org/10.1038/s41593-023-01359-8
[2023] Heterogenous Genetic, Clinical, and Imaging Features in Patients with Neuronal Intranuclear Inclusion Disease Carrying NOTCH2NLC Repeat Expansion
DOI: https://doi.org/10.3390/brainsci13060955
[2023] Frequency of anti-IgLON5 disease in patients who meet the clinical diagnostic criteria for progressive supranuclear palsy/corticobasal syndrome (S22.010)
DOI: https://doi.org/10.1212/wnl.0000000000202665
[2023] Investigation into the Difference of Cognitive Decline between the Centenarians and Alzheimer's Disease (P4-6.004)
DOI: https://doi.org/10.1212/wnl.0000000000201736
[2023] Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort
DOI: https://doi.org/10.1038/s41398-023-02411-8
[2023] Brain p3‐Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β‐peptide
DOI: https://doi.org/10.15252/emmm.202217052
[2023] Soluble form of the APP fragment, sAPPβ, positively regulates tau secretion
DOI: https://doi.org/10.1016/j.neures.2023.03.002
[2023] Novel partial deletions, frameshift and missense mutations of CSF1R in patents with CSF1R‐related leukoencephalopathy
DOI: https://doi.org/10.1111/ene.15796
[2023] The clinical application of optimized AT(N) classification in Alzheimer’s clinical syndrome (ACS) and non-ACS conditions
DOI: https://doi.org/10.1016/j.neurobiolaging.2023.03.007
[2023] Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer's Disease
DOI: https://doi.org/10.1002/ana.26620
[2023] Initial symptoms of early‐onset dementia in Japan: nationwide survey
DOI: https://doi.org/10.1111/psyg.12949
[2023] Cross‐sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle‐aged individuals with a parental history of either autosomal dominant or late‐onset Alzheimer's disease
DOI: https://doi.org/10.1002/alz.12912
[2023] Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer’s disease
DOI: https://doi.org/10.1093/brain/awac498
[2023] Clinical course of pathologically confirmed corticobasal degeneration and corticobasal syndrome
DOI: https://doi.org/10.1093/braincomms/fcad296
[2022] Decreased circulating branched-chain amino acids are associated with development of Alzheimer’s disease in elderly individuals with mild cognitive impairment
DOI: https://doi.org/10.3389/fnut.2022.1040476
[2022] Different AT(N) profiles and clinical progression classified by two different N markers using total tau and neurofilament light chain in cerebrospinal fluid
DOI: https://doi.org/10.1136/bmjno-2022-000321
[2022] Involvement of inflammation in the medial temporal region in the development of agitation in Alzheimer's disease: an in vivo positron emission tomography study
DOI: https://doi.org/10.1111/psyg.12915
[2022] Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid
DOI: https://doi.org/10.1038/s41586-022-05397-3
[2022] Estimation of blood-based biomarkers of glial activation related to neuroinflammation
DOI: https://doi.org/10.1016/j.bbih.2022.100549
[2022] High frequency ofHTRA1ANDABCC6mutations in Japanese patients with adult-onset cerebral small vessel disease
DOI: https://doi.org/10.1136/jnnp-2022-329917
[2022] Idiopathic rapid eye movement sleep behavior disorder in Japan: An observational study.
[2022] Biallelic COX10 Mutations and PMP22 Deletion in a Family With Leigh Syndrome and Hereditary Neuropathy With Liability to Pressure Palsy
DOI: https://doi.org/10.1212/nxg.0000000000200030
[2022] Black rice bran intake reduces phosphorylated tau levels and enhances insulin signaling in the brain of aged normal mice
DOI: https://doi.org/10.1093/bbb/zbac125
[2022] Idiopathic rapid eye movement sleep behavior disorder in Japan: An observational study
DOI: https://doi.org/10.1016/j.parkreldis.2022.08.011
[2022] Multimodal analyses of a non-human primate model harboring mutant amyloid precursor protein transgenes driven by the human EF1α promoter.
DOI: https://doi.org/10.1016/j.neures.2022.08.008
[2022] I. Genomic Medicine in Dementia
DOI: https://doi.org/10.2169/naika.111.1504
[2022] Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan
DOI: https://doi.org/10.1093/brain/awac238
[2022] Covariance-based vs. correlation-based functional connectivity dissociates healthy aging from Alzheimer disease
DOI: https://doi.org/10.1016/j.neuroimage.2022.119511
[2022] Clinical correlations of cerebrospinal fluid biomarkers including neuron-glia 2 and neurofilament light chain in patients with multiple system atrophy
DOI: https://doi.org/10.1016/j.parkreldis.2022.07.007
[2022] The Use of Lumbar Puncture and Safety Recommendations in Alzheimer’s Disease: A Plain Language Summary
DOI: https://doi.org/10.2217/nmt-2022-0012
[2022] Effects of an essential amino acid mixture on behavioral and psychological symptoms of dementia and executive function in patients with Alzheimer's disease: A double‐blind, randomized, placebo‐controlled exploratory clinical trial
DOI: https://doi.org/10.1002/gps.5782
[2022] Four‐repeat tauopathies and late‐onset psychiatric disorders: Etiological relevance or incidental findings?
DOI: https://doi.org/10.1111/neup.12820
[2022] Amygdala granular fuzzy astrocytes as lesions preceding development of argyrophilic grains: data from 239 autopsy cases
DOI: https://doi.org/10.17879/freeneuropathology-2022-4285
[2022] Frontotemporal Lobar Degeneration With Unclassifiable 4-Repeat Tauopathy Mimicking Globular Glial Tauopathy
DOI: https://doi.org/10.1093/jnen/nlac039
[2022] Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology
DOI: https://doi.org/10.1126/sciadv.abm5029
[2022] Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease
DOI: https://doi.org/10.1002/alz.12684

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AI 要約（直近 5 年の研究成果）

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研究成果（100 件）

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