Nagomi Kurebayashi 研究室

主宰者：Nagomi Kurebayashi

順天堂大学・Juntendo University Hospital

AI 要約（直近 5 年の研究成果）

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研究成果（58 件）

[2026] BPS2026 – Enhanced depolarization-induced calcium release by CaV1.1 variants associated with malignant hyperthermia susceptibility
DOI: https://doi.org/10.1016/j.bpj.2025.11.2440
[2026] Structural basis for Ca 2+ -dependent allosteric modulation of cardiac ryanodine receptor by Ryanozole
DOI: https://doi.org/10.64898/2026.05.11.724262
[2026] A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function
DOI: https://doi.org/10.1111/bph.70459
[2026] BPS2026 – High-throughput screening for ryanodine receptor modulators using a novel green ER Ca2+ sensor protein
DOI: https://doi.org/10.1016/j.bpj.2025.11.2436
[2026] Pathogenic CaV1.1 Variants Cause Hyperpolarizing Shift of Depolarization-Induced Ca2+ Release in Malignant Hyperthermia Susceptibility
DOI: https://doi.org/10.1038/s42003-026-10281-1
[2025] Crystal structures of Ryanodine Receptor reveal dantrolene and azumolene interactions guiding inhibitor development
DOI: https://doi.org/10.1038/s41467-025-65096-1
[2025] RyR1-mediated Ca 2+ -induced Ca 2+ release plays a negligible role in excitation–contraction coupling of normal skeletal muscle
DOI: https://doi.org/10.1073/pnas.2500449122
[2025] Development of selective RyR2 inhibitors with a pharmacophore containing a parabanic acid skeleton
DOI: https://doi.org/10.1039/d5md00183h
[2024] Pivotal role of S5 segment and S5–S6 luminal loop in the channel gating of type 1 ryanodine receptor (RyR1)
DOI: https://doi.org/10.1016/j.bpj.2023.11.1558
[2024] Functional analysis of Ca2+ signaling in a mouse model of malignant hyperthermia
DOI: https://doi.org/10.1016/j.bpj.2023.11.1551

続きを表示（残り 48 件）

[2024] Discovery and Structure–Activity Relationship of a Ryanodine Receptor 2 Inhibitor
DOI: https://doi.org/10.1248/cpb.c24-00114
[2024] Effects of a high-affinity and selective RyR2 inhibitor on Ca2+ signals in cardiomyocytes and arrhythmias in CPVT model mice
DOI: https://doi.org/10.1016/j.bpj.2023.11.247
[2024] Dual role of the S5 segment in type 1 ryanodine receptor channel gating
DOI: https://doi.org/10.1038/s42003-024-06787-1
[2024] Carvedilol suppresses ryanodine receptor-dependent Ca2+ bursts in human neurons bearing PSEN1 variants found in early onset Alzheimer’s disease
DOI: https://doi.org/10.1371/journal.pone.0291887
[2024] An inherited life-threatening arrhythmia model established by screening randomly mutagenized mice
DOI: https://doi.org/10.1073/pnas.2218204121
[2023] Effects of a novel RyR2 specific inhibitor on arrhythmias in catecholaminergic polymorphic ventricular tachycardia (CPVT) model mice
DOI: https://doi.org/10.1254/jpssuppl.97.0_1-b-o03-1
[2023] Effects of voluntary exercise and administration of renin angiotensin inhibitor on cardiac function in inherited dilated cardiomyopathy model
DOI: https://doi.org/10.1016/j.bpj.2022.11.833
[2023] Screening for Novel Type 2 Ryanodine Receptor Inhibitors by Endoplasmic Reticulum Ca2+ Monitoring
DOI: https://doi.org/10.1124/molpharm.123.000720
[2023] Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes
DOI: https://doi.org/10.1161/circep.122.011387
[2023] Reconstitution of depolarization-induced Ca2+ release for validation of skeletal muscle disease mutations and drug discovery
DOI: https://doi.org/10.1016/j.bpj.2022.11.402
[2023] A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment
DOI: https://doi.org/10.1016/j.ejmech.2023.115910
[2023] Dysfunctional Ca2+ dynamics in primary skeletal myocytes from R2509C-RYR1 mice
DOI: https://doi.org/10.1016/j.bpj.2022.11.2072
[2023] Arrhythmia severity in mouse models harboring RyR2 mutations with varied extent of channel activity
DOI: https://doi.org/10.1016/j.bpj.2022.11.1395
[2023] Novel CACNA1S mutations for malignant hyperthermia enhance depolarization-induced Ca2+ release
DOI: https://doi.org/10.1254/jpssuppl.97.0_3-b-o16-3
[2022] Anti-arrhythmic effects of novel RyR2 inhibitors screened from well-characterized drug library by ER Ca2+ monitoring.
DOI: https://doi.org/10.1254/jpssuppl.95.0_3-o-107
[2022] Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes
DOI: https://doi.org/10.1085/jgp.202213136
[2022] Development of a water-soluble ryanodine receptor 1 inhibitor
DOI: https://doi.org/10.1016/j.bmc.2022.117027
[2022] Involvement of <scp>kallikrein‐PAR2</scp>‐proinflammatory pathway in severe trastuzumab‐induced cardiotoxicity
DOI: https://doi.org/10.1111/cas.15508
[2022] A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery
DOI: https://doi.org/10.1085/jgp.202213230
[2022] Heat-hypersensitive mutants of ryanodine receptor type 1 revealed by microscopic heating
DOI: https://doi.org/10.1073/pnas.2201286119
[2022] Elucidation of the mechanisms of trastuzumab-induced severe cardiotoxicity using patient-derived iPSCs cardiomyocyte model.
DOI: https://doi.org/10.1200/jco.2022.40.16_suppl.e24065
[2022] Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations
DOI: https://doi.org/10.1038/s41467-022-30429-x
[2022] Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2
DOI: https://doi.org/10.1085/jgp.202112869
[2022] Loss-of-function mutations in cardiac ryanodine receptor channel cause various types of arrhythmias including long QT syndrome.
[2022] High-throughput platform of reconstituted skeletal muscle depolarization-induced Ca2+release in HEK293 cells
DOI: https://doi.org/10.1016/j.bpj.2021.11.2259
[2022] Differential impacts of arrhythmia-linked loss-of-function RyR2 mutations on Ca2+ signaling in cardiac cells
DOI: https://doi.org/10.1016/j.bpj.2021.11.1861
[2022] Phosphorylation of cardiac ryanodine receptor (RyR2): a structure-function study of phosphomimetic and phospho-null triple mutants
DOI: https://doi.org/10.1016/j.bpj.2021.11.867
[2022] Loss-of-function RyR2 mutations cause various types of arrhythmias through divergent abnormal Ca2+ signaling
DOI: https://doi.org/10.1254/jpssuppl.95.0_3-o-108
[2022] Evaluation of RyR2 inhibitors as anti-arrhythmic drugs using novel CPVT model mice
DOI: https://doi.org/10.1254/jpssuppl.95.0_3-p-228
[2022] Development of a Water-Soluble Ryanodine Receptor 1 Inhibitor
DOI: https://doi.org/10.2139/ssrn.4189785
[2022] Therapeutic effects of voluntary wheel running on cancer cachexia-induced cardiac dysfunction: Approach from the perspective of Cardio-oncology
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-p-046
[2022] Evaluation of antiarrhythmic agents for catecholaminergic polymorphic ventricular tachycardia (CPVT) using multiple lines of RyR2-mutant mouse models
DOI: https://doi.org/10.1254/jpssuppl.96.0_3-b-o08-3
[2022] Establishment of reconstituted depolarization-induced Ca2+ release platform for drug discovery of skeletal muscle diseases
DOI: https://doi.org/10.1254/jpssuppl.96.0_4-b-o13-1
[2022] Comparison of voluntary exercise and renin angiotensin inhibitor administration in a mouse model of dilated cardiomyopathy
DOI: https://doi.org/10.1254/jpssuppl.96.0_3-b-p-216
[2021] Therapeutic effects of novel type1 ryanodine receptor inhibitor on skeletal muscle diseases
DOI: https://doi.org/10.1254/fpj.21068
[2021] Sudden death after inappropriate shocks of implantable cardioverter defibrillator in a catecholaminergic polymorphic ventricular tachycardia case with a novel RyR2 mutation
DOI: https://doi.org/10.1016/j.jelectrocard.2021.09.015
[2021] A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke
DOI: https://doi.org/10.1038/s41467-021-24644-1
[2021] Cryo-Em Studies of Phosphomimetic and Phospho-Null Triple Mutants of Cardiac Ryanodine Receptor (RyR2)
DOI: https://doi.org/10.1016/j.bpj.2020.11.1574
[2021] Purification of Recombinant Wild Type and Mutant Ryanodine Receptors Expressed in HEK293 Cells
DOI: https://doi.org/10.21769/bioprotoc.4112
[2021] Gender differences in the effect of spontaneous exercise on heart failure in DCM model mice
DOI: https://doi.org/10.1254/jpssuppl.94.0_3-p2-10
[2021] Loss-of-function mutations in cardiac ryanodine receptor channel cause various types of arrhythmias including long QT syndrome
DOI: https://doi.org/10.1093/europace/euab250
[2021] Inhibition of endothelin A receptor by a novel, selective receptor antagonist enhances morphine-induced analgesia: Possible functional interaction of dimerized endothelin A and μ-opioid receptors
DOI: https://doi.org/10.1016/j.biopha.2021.111800
[2021] Differential effects of the formin inhibitor SMIFH2 on contractility and Ca2+ handling in frog and mouse cardiomyocytes
DOI: https://doi.org/10.1111/gtc.12873
[2021] Differential effects of the formin inhibitor SMIFH2 on contractility and Ca2+ handling in frog and mouse cardiomyocytes
[2021] Cancer cachexia-induced myocardial impairment could be improved by voluntary wheel running
DOI: https://doi.org/10.1254/jpssuppl.94.0_1-o-d2-4
[2021] Characterization of novel RyR1 selective inhibitors identified by ER Ca2+ measurements
DOI: https://doi.org/10.1254/jpssuppl.94.0_3-p2-27
[2021] Identification of binding site for a novel RyR1-selective inhibitor
DOI: https://doi.org/10.1254/jpssuppl.94.0_3-p2-26
[2021] Effects of RyR2 specific inhibitors on arrhythmia in CPVT model mice
DOI: https://doi.org/10.1254/jpssuppl.94.0_1-o-d3-1

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AI 要約（直近 5 年の研究成果）

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研究成果（58 件）

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